Research Output 1999 2019

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2019

Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide

Nitta, R. T., Bolin, S., Luo, E., Solow-Codero, D. E., Samghabadi, P., Purzner, T., Aujla, P. S., Nwagbo, G., Cho, Y-J. & Li, G., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Open Access
temozolomide
Casein Kinase II
Medulloblastoma
O(6)-Methylguanine-DNA Methyltransferase
Growth
5 Citations (Scopus)

MR imaging-based radiomic signatures of distinct molecular subgroups of medulloblastoma

Iv, M., Zhou, M., Shpanskaya, K., Perreault, S., Wang, Z., Tranvinh, E., Lanzman, B., Vajapeyam, S., Vitanza, N. A., Fisher, P. G., Cho, Y-J., Laughlin, S., Ramaswamy, V., Taylor, M. D., Cheshier, S. H., Grant, G. A., Young Poussaint, T., Gevaert, O. & Yeom, K. W., Jan 1 2019, In : American Journal of Neuroradiology. 40, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Medulloblastoma
Area Under Curve
Neoplasms
Pediatrics
Nonparametric Statistics
1 Citation (Scopus)
Open Access
Cannabidiol
Epilepsy
Pharmacokinetics
Pediatrics
Pharmaceutical Preparations
2018
2 Citations (Scopus)

Baseline and outcome assessment in pediatric status epilepticus

Jafarpour, S., Stredny, C. M., Piantino, J. & Chapman, K. E., Jan 1 2018, (Accepted/In press) In : Seizure.

Research output: Contribution to journalArticle

Status Epilepticus
Quality of Life
Outcome Assessment (Health Care)
Pediatrics
Mortality
6 Citations (Scopus)

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Bolin, S., Borgenvik, A., Persson, C. U., Sundström, A., Qi, J., Bradner, J. E., Weiss, W. A., Cho, Y-J., Weishaupt, H. & Swartling, F. J., May 1 2018, In : Oncogene. 37, 21, p. 2850-2862 13 p.

Research output: Contribution to journalArticle

Open Access
Medulloblastoma
Cyclin-Dependent Kinases
Doxycycline
Therapeutics
Cell Cycle Checkpoints
6 Citations (Scopus)

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

Purzner, T., Purzner, J., Buckstaff, T., Cozza, G., Gholamin, S., Rusert, J. M., Hartl, T. A., Sanders, J., Conley, N., Ge, X., Langan, M., Ramaswamy, V., Ellis, L., Litzenburger, U., Bolin, S., Theruvath, J., Nitta, R., Qi, L., Li, X. N., Li, G. & 7 others, Taylor, M. D., Wechsler-Reya, R. J., Pinna, L. A., Cho, Y-J., Fuller, M. T., Elias, J. E. & Scott, M. P., Sep 11 2018, In : Science Signaling. 11, 547, eaau5147.

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Phosphotransferases
Tumors
Phosphorylation
4 Citations (Scopus)

Mortality after pediatric arterial ischemic stroke

International Pediatric Stroke Study Investigators, May 1 2018, In : Pediatrics. 141, 5, e20174146.

Research output: Contribution to journalArticle

Stroke
Pediatrics
Hospital Mortality
Mortality
Odds Ratio

Optimizing Neurocritical Care Follow-Up Through the Integration of Neuropsychology

Dodd, J. N., Hall, T., Guilliams, K., Guerriero, R. M., Wagner, A., Malone, S., Williams, C. N., Hartman, M. E. & Piantino, J., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

Neuropsychology
Aftercare
Critical Care
Patient Care
Parents

Serotonin Syndrome and Hippocampal Infarction

French, S. & Wray, C., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

Serotonin Syndrome
Infarction
2017
10 Citations (Scopus)

A first-in-class twist1 inhibitor with activity in oncogene-driven lung cancer

Yochum, Z. A., Cades, J., Mazzacurati, L., Neumann, N. M., Khetarpal, S. K., Chatterjee, S., Wang, H., Attar, M. A., Huang, E. H. B., Chatley, S. N., Nugent, K., Somasundaram, A., Engh, J. A., Ewald, A. J., Cho, Y-J., Rudin, C. M., Tran, P. T. & Burns, T. F., Dec 1 2017, In : Molecular Cancer Research. 15, 12, p. 1764-1776 13 p.

Research output: Contribution to journalArticle

Open Access
Harmine
Oncogenes
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Epithelial-Mesenchymal Transition
57 Citations (Scopus)

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

Gholamin, S., Mitra, S. S., Feroze, A. H., Liu, J., Kahn, S. A., Zhang, M., Esparza, R., Richard, C., Ramaswamy, V., Remke, M., Volkmer, A. K., Willingham, S., Ponnuswami, A., McCarty, A., Lovelace, P., Storm, T. A., Schubert, S., Hutter, G., Narayanan, C., Chu, P. & 14 others, Raabe, E. H., Harsh, G., Taylor, M. D., Monje, M., Cho, Y-J., Majeti, R., Volkmer, J. P., Fisher, P. G., Grant, G., Steinberg, G. K., Vogel, H., Edwards, M., Weissman, I. L. & Cheshier, S. H., Mar 15 2017, In : Science Translational Medicine. 9, 381, eaaf2968.

Research output: Contribution to journalArticle

Antibodies, Monoclonal, Humanized
Brain Neoplasms
Anti-Idiotypic Antibodies
Pediatrics
Medulloblastoma
1 Citation (Scopus)

Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line

Henderson, J. J., Wagner, J. P., Hofmann, N. E., Eide, C. A., Cho, Y-J., Druker, B. & Davare, M., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

Medulloblastoma
Tuberous Sclerosis
Cell Line
Mutation
Phosphotransferases
10 Citations (Scopus)

Pediatric oncology enters an era of precision medicine

Seibel, N. L., Janeway, K., Allen, C. E., Chi, S. N., Cho, Y-J., Glade Bender, J. L., Kim, A. R., Laetsch, T. W., Irwin, M. S., Takebe, N., Tricoli, J. V. & Parsons, D. W., May 1 2017, In : Current problems in cancer. 41, 3, p. 194-200 7 p.

Research output: Contribution to journalArticle

Precision Medicine
Pediatrics
Neoplasms
Genomics
Multicenter Studies
139 Citations (Scopus)

The whole-genome landscape of medulloblastoma subtypes

Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C., Kool, M. & 67 others, Zapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y-J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., Jul 19 2017, In : Nature. 547, 7663, p. 311-317 7 p.

Research output: Contribution to journalArticle

Open Access
Medulloblastoma
Genome
Neoplasm Genes
Therapeutics
Genomics
2016
6 Citations (Scopus)

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma

Svalina, M. N., Kikuchi, K., Abraham, J., Lal, S., Davare, M., Settelmeyer, T. P., Young, M. C., Peckham, J. L., Cho, Y-J., Michalek, J. E., Hernandez, B. S., Berlow, N. E., Jackson, M., Guillaume, D. J., Selden, N., Bigner, D. D., Nazemi, K., Green, S. C., Corless, C., Gultekin, S. & 4 others, Mansoor, A., Rubin, B. P., Woltjer, R. R. & Keller, C., Jun 3 2016, In : Scientific Reports. 6, 27012.

Research output: Contribution to journalArticle

Medulloblastoma
Peptide Hydrolases
Cerebrospinal Fluid
Neoplasm Metastasis
Plasminogen Activator Inhibitor 1
22 Citations (Scopus)

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., Schubert, S., Vaka, D., Morrissy, S., Li, Y., Kool, M., Hovestadt, V., Jones, D. T. W., Northcott, P. A., Risch, T., Warnatz, H. J., Yaspo, M. L., Adams, C. M., Leib, R. D., Breese, M. & 8 others, Marra, M. A., Malkin, D., Lichter, P., Doudna, J. A., Pfister, S. M., Taylor, M. D., Chang, H. Y. & Cho, Y-J., May 10 2016, In : Oncotarget. 7, 19, p. 28169-28182 14 p.

Research output: Contribution to journalArticle

Open Access
Medulloblastoma
5' Untranslated Regions
RNA
DEAD-box RNA Helicases
Cerebellar Neoplasms
4 Citations (Scopus)

Pediatric neurocritical care in the 21st century: From empiricism to evidence

Wainwright, M. S., Hansen, G. & Piantino, J., Apr 1 2016, In : Current Opinion in Critical Care. 22, 2, p. 106-112 7 p.

Research output: Contribution to journalArticle

Empiricism
Pediatrics
Critical Care
Critical Illness
Nervous System
1 Citation (Scopus)

Pediatric patients on ketogenic diet undergoing general anesthesia—a medical record review

Soysal, E., Gries, H. & Wray, C., Dec 1 2016, In : Journal of Clinical Anesthesia. 35, p. 170-175 6 p.

Research output: Contribution to journalArticle

Ketogenic Diet
Medical Records
Pediatrics
General Anesthesia
Seizures
2 Citations (Scopus)

Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy

Rilinger, J. F., Smith, C. M., deRegnier, R. A. O., Goldstein, J. L., Mills, M. G., Reynolds, M., Backer, C. L., Burrowes, D. M., Mehta, P., Piantino, J. & Wainwright, M. S., Apr 20 2016, (Accepted/In press) In : Journal of Stroke and Cerebrovascular Diseases.

Research output: Contribution to journalArticle

Nervous System Trauma
Extracorporeal Membrane Oxygenation
Pediatrics
Blood Flow Velocity
Cerebrovascular Circulation
2013
9 Citations (Scopus)

17q21.31 Microdeletion associated with infantile spasms

Wray, C., Jan 2013, In : European Journal of Medical Genetics. 56, 1, p. 59-61 3 p.

Research output: Contribution to journalArticle

Infantile Spasms
Seizures
Nervous System Malformations
Corticotropin-Releasing Hormone Receptors
Spasm
11 Citations (Scopus)

A new mutation in MT-ND1 m.3928G>C p.V208L causes Leigh disease with infantile spasms

Wray, C., Friederich, M. W., du Sart, D., Pantaleo, S., Smet, J., Kucera, C., Fenton, L., Scharer, G., Van Coster, R. & Van Hove, J. L. K., Nov 2013, In : Mitochondrion. 13, 6, p. 656-661 6 p.

Research output: Contribution to journalArticle

Leigh Disease
Infantile Spasms
Ubiquinone
Mitochondrial DNA
Mutation
10 Citations (Scopus)

Focal cortical dysplasia is more common in boys than in girls

Ortiz-González, X. R., Poduri, A., Roberts, C., Sullivan, J. E., Marsh, E. D. & Porter, B. E., Apr 2013, In : Epilepsy and Behavior. 27, 1, p. 121-123 3 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Sex Distribution
Population
Epilepsy
Cohort Studies
2012
23 Citations (Scopus)

Vagus nerve stimulation for partial and generalized epilepsy from infancy to adolescence: Clinical article

Thompson, E. M., Wozniak, S. E., Roberts, C., Kao, A., Anderson, V. & Selden, N., Sep 2012, In : Journal of Neurosurgery: Pediatrics. 10, 3, p. 200-205 6 p.

Research output: Contribution to journalArticle

Vagus Nerve Stimulation
Generalized Epilepsy
Partial Epilepsy
Seizures
Anticonvulsants
2011
18 Citations (Scopus)

Focal seizure propagation in the intracranial EEG

Jenssen, S., Roberts, C., Gracely, E. J., Dlugos, D. J. & Sperling, M. R., Jan 2011, In : Epilepsy Research. 93, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Seizures
Temporal Lobe
Stroke
Brain
Electroencephalography
14 Citations (Scopus)

Skull-fixated fiducial markers improve accuracy in staged frameless stereotactic epilepsy surgery in children: Clinical article

Thompson, E. M., Anderson, G., Roberts, C., Hunt, M. A. & Selden, N., Jan 2011, In : Journal of Neurosurgery: Pediatrics. 7, 1, p. 116-119 4 p.

Research output: Contribution to journalArticle

Fiducial Markers
Skull
Epilepsy
Skin
Pediatrics
4 Citations (Scopus)

Transendoscopic intraoperative recording of gelastic seizures from a hypothalamic hamartoma

Roberts, C., Thompson, E. M. & Selden, N., Oct 2011, In : Pediatric Neurosurgery. 47, 2, p. 147-151 5 p.

Research output: Contribution to journalArticle

Laughter
Seizures
Biopsy
Electroencephalography
Hamartoma
2008
50 Citations (Scopus)

Cerebral blood flow heterogeneity in preterm sheep: Lack of physiologic support for vascular boundary zones in fetal cerebral white matter

McClure, M. M., Riddle, A., Manese, M., Luo, N. L., Rorvik, D. A., Kelly, K. A., Barlow, C. H., Kelly, J. J., Vinecore, K., Roberts, C., Hohimer, A. R. & Back, S., May 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 5, p. 995-1008 14 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Blood Vessels
Sheep
Ischemia
Wounds and Injuries
70 Citations (Scopus)

Qualitative comparison of 3-T and 1.5-T MRI in the evaluation of epilepsy

Phal, P. M., Usmanov, A., Nesbit, G., Anderson, J. J., Spencer, D., Wang, P., Helwig, J. A., Roberts, C. & Hamilton, B., Sep 2008, In : American Journal of Roentgenology. 191, 3, p. 890-895 6 p.

Research output: Contribution to journalArticle

Epilepsy
Partial Epilepsy
Signal-To-Noise Ratio
Neuroimaging
Artifacts
1999
57 Citations (Scopus)

Chondrocyte differentiation in a rat mesenchymal cell line

Lunstrum, G. P., Keene, D. R., Weksler, N. B., Cho, Y-J., Cornwall, M. & Horton, W. A., Jan 1 1999, In : Journal of Histochemistry and Cytochemistry. 47, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Chondrocytes
Cell Line
Collagen Type X
Suspensions
Collagen Type XI