Oregon Clinical & Translational Research Institute

Research Output 1994 2019

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2019
6 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors

Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii

Lie, S., Rochet, E., Segerdell, E., Ma, Y., Ashander, L. M., Shadforth, A. M. A., Blenkinsop, T. A., Michael, M. Z., Appukuttan, B., Wilmot, B. & Smith, J. R., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Retinal Pigments
Toxoplasmosis
Toxoplasma
Ocular Toxoplasmosis
Epithelial Cells
3 Citations (Scopus)

Oral Vitamin C (500 mg/d) to pregnant smokers improves infant airway function at 3 months (VCSIP) a randomized trial

McEvoy, C. C., Shorey-Kendrick, L. E., Milner, K., Schilling, D., Tiller, C., Vuylsteke, B., Scherman, A., Jackson, K., Haas, D. M., Harris, J., Schuff, R., Park, B., Vu, A., Kraemer, D., Mitchell, J., Metz, J., Gonzales, D., Bunten, C., Spindel, E., Tepper, R. S. & 1 others, Morris, C., May 1 2019, In : American journal of respiratory and critical care medicine. 199, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Placebos
Respiratory Function Tests
Nicotinic Receptors
Confidence Intervals
2018
143 Citations (Scopus)

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, Jun 22 2018, In : Science. 360, 6395, 8757.

Research output: Contribution to journalArticle

Brain Diseases
Psychiatry
Phenotype
Genetic Heterogeneity
Genome-Wide Association Study
31 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

Untranslated RNA
Drinking
Genes
Gene Expression
Transcriptome

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Leukemia
Acute Myeloid Leukemia
Myeloid Cells
Mitogen-Activated Protein Kinases
11 Citations (Scopus)
Endophenotypes
Attention Deficit Disorder with Hyperactivity
Short-Term Memory
Arousal
Structural Models
2017
6 Citations (Scopus)

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. & Tyner, J., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
High-Throughput Nucleotide Sequencing
Ubiquitination
Leukemia
5 Citations (Scopus)

Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics

Nielson, C., Wiedrick, J., Shen, J., Jacobs, J., Baker, E. S., Baraff, A., Piehowski, P., Lee, C., Baratt, A., Petyuk, V., McWeeney, S., Lim, J. Y., Bauer, D. C., Lane, N. E., Cawthon, P. M., Smith, R. D., Lapidus, J. & Orwoll, E., 2017, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Pelvic Bones
Proteomics
Bone Density
Hip Fractures
Serum
3 Citations (Scopus)

NFAT5 and SLC4A10 loci associate with plasma osmolality

Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P. & 86 others, Cucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

Osmolar Concentration
Meta-Analysis
Water
Sodium
Hypernatremia
7 Citations (Scopus)

Sequencing of sporadic Attention-Deficit Hyperactivity Disorder (ADHD) identifies novel and potentially pathogenic de novo variants and excludes overlap with genes associated with autism spectrum disorder

Kim, D. S., Burt, A. A., Ranchalis, J. E., Wilmot, B., Smith, J. D., Patterson, K. E., Coe, B. P., Li, Y. K., Bamshad, M. J., Nikolas, M., Eichler, E. E., Swanson, J. M., Nigg, J., Nickerson, D. A. & Jarvik, G. P., 2017, (Accepted/In press) In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Genes
Intellectual Disability
Exome
Autism Spectrum Disorder
5 Citations (Scopus)

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Zhang, H., Means, S., Schultz, A. R., Watanabe-Smith, K., Medeiros, B. C., Bottomly, D., Wilmot, B., McWeeney, S., Kükenshöner, T., Hantschel, O. & Tyner, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4258-4267 10 p.

Research output: Contribution to journalArticle

Cysteine
Mutation
Leukemia, Neutrophilic, Chronic
Leukemia
Granulocyte Colony-Stimulating Factor Receptors
5 Citations (Scopus)

Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health

McEvoy, C. C., Milner, K. F., Scherman, A. J., Schilling, D. G., Tiller, C. J., Vuylsteke, B., Shorey-Kendrick, L. E., Spindel, E., Schuff, R., Mitchell, J., Peters, D., Metz, J., Haas, D., Jackson, K., Tepper, R. S. & Morris, C., Jul 1 2017, In : Contemporary Clinical Trials. 58, p. 66-77 12 p.

Research output: Contribution to journalArticle

Primary Prevention
Smoke
Ascorbic Acid
Tobacco
Randomized Controlled Trials
2016
5 Citations (Scopus)

HitWalker2: Visual analytics for precision medicine and beyond

Bottomly, D., McWeeney, S. & Wilmot, B., Apr 15 2016, In : Bioinformatics. 32, 8, p. 1253-1255 3 p.

Research output: Contribution to journalArticle

Visual Analytics
Precision Medicine
Prioritization
Bioelectric potentials
Medicine
13 Citations (Scopus)

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. & Tyner, J., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Leukemia
Phosphotransferases
Mutation
Leukemia, Myelomonocytic, Chronic
17 Citations (Scopus)

Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach

Mooney, M., McWeeney, S., Faraone, S., Hinney, A., Hebebrand, J., Nigg, J. T. & Wilmot, B., 2016, (Accepted/In press) In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Genome-Wide Association Study
Genes
Fibroblast Growth Factor Receptors
Potassium Channels
2015
19 Citations (Scopus)

Gene set analysis: A step-by-step guide

Mooney, M. & Wilmot, B., Oct 1 2015, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 168, 7, p. 517-527 11 p.

Research output: Contribution to journalArticle

Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Research Personnel
17 Citations (Scopus)

Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects

Eriksson, J., Evans, D. S., Nielson, C., Shen, J., Srikanth, P., Hochberg, M., McWeeney, S., Cawthon, P. M., Wilmot, B., Zmuda, J., Tranah, G., Mirel, D. B., Challa, S., Mooney, M., Crenshaw, A., Karlsson, M., Mellström, D., Vandenput, L., Orwoll, E. & Ohlsson, C., Jan 1 2015, In : Journal of Bone and Mineral Research. 30, 1, p. 184-194 11 p.

Research output: Contribution to journalArticle

Bone Density
Osteoporotic Fractures
Sweden
Area Under Curve
Meta-Analysis

Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status: A pilot study

Hall, T., Steiner, R. D., Wright, H., Wilmot, B., Roullet, J-B., Peters, M. & Harris, M., Sep 1 2015, In : New Horizons in Translational Medicine. 2, 6-7, p. 137-146 10 p.

Research output: Contribution to journalArticle

Sterols
Autistic Disorder
Lipids
Genes
Lipid Metabolism
30 Citations (Scopus)

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2

Wilmot, B., Fry, R., Smeester, L., Musser, E. D., Mill, J. & Nigg, J., 2015, (Accepted/In press) In : Journal of Child Psychology and Psychiatry and Allied Disciplines.

Research output: Contribution to journalArticle

DNA Methylation
Attention Deficit Disorder with Hyperactivity
DNA
Methylation
Genes

plethy: Management of whole body plethysmography data in R

Bottomly, D., Wilmot, B. & McWeeney, S., Apr 29 2015, In : BMC Bioinformatics. 16, 1, 134.

Research output: Contribution to journalArticle

Whole Body Plethysmography
Plethysmography
Exploratory Data Analysis
Mouse
Severe Acute Respiratory Syndrome
11 Citations (Scopus)

Predisposition to childhood otitis media and genetic polymorphisms within the toll-like receptor 4 (TLR4) Locus

Hafren, L., Einarsdottir, E., Kentala, E., Hammaren-Malmi, S., Bhutta, M. F., Macarthur, C., Wilmot, B., Casselbrant, M., Conley, Y. P., Weeks, D. E., Mandel, E. M., Vaarala, O., Kallio, A., Melin, M., Nieminen, J. K., Leinonen, E., Kere, J. & Mattila, P. S., Jul 15 2015, In : PLoS One. 10, 7, e0132551.

Research output: Contribution to journalArticle

otitis media
Toll-Like Receptor 4
Otitis Media
Genetic Polymorphisms
Polymorphism
4 Citations (Scopus)

Splicing landscape of the eight collaborative cross founder strains

Zheng, C., Wilmot, B., Walter, N. A. R., Oberbeck, D., Kawane, S., Searles, R., McWeeney, S. & Hitzemann, R., Feb 5 2015, In : BMC Genomics. 16, 1, 52.

Research output: Contribution to journalArticle

Transcriptome
Exons
Population
High-Throughput Nucleotide Sequencing
Inbred Strains Mice
12 Citations (Scopus)

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P., Heiser, L., Tyner, J. & Thomas, G., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Cell Survival
Cell Proliferation
Organ Size
8 Citations (Scopus)

Therapeutically targetable ALK mutations in leukemia

Maxson, J., Davare, M., Luty, S. B., Eide, C. A., Chang, B., Loriaux, M., Tognon, C. E., Bottomly, D., Wilmot, B., McWeeney, S., Druker, B. & Tyner, J., Jun 1 2015, In : Cancer Research. 75, 11, p. 2146-2150 5 p.

Research output: Contribution to journalArticle

Leukemia
Mutation
Phosphotransferases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Point Mutation
167 Citations (Scopus)

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C., Walter, K., Pettersson-Kymmer, U., McCarthy, S., Eriksson, J. & 136 others, Kwan, T., Jhamai, M., Trajanoska, K., Memari, Y., Min, J., Huang, J., Danecek, P., Wilmot, B., Li, R., Chou, W. C., Mokry, L. E., Moayyeri, A., Claussnitzer, M., Cheng, C. H., Cheung, W., Medina-Gómez, C., Ge, B., Chen, S. H., Choi, K., Oei, L., Fraser, J., Kraaij, R., Hibbs, M. A., Gregson, C. L., Paquette, D., Hofman, A., Wibom, C., Tranah, G. J., Marshall, M., Gardiner, B. B., Cremin, K., Auer, P., Hsu, L., Ring, S., Tung, J. Y., Thorleifsson, G., Enneman, A. W., Van Schoor, N. M., De Groot, L. C. P. G. M., Van Der Velde, N., Melin, B., Kemp, J. P., Christiansen, C., Sayers, A., Zhou, Y., Calderari, S., Van Rooij, J., Carlson, C., Peters, U., Berlivet, S., Dostie, J., Uitterlinden, A. G., Williams, S. R., Farber, C., Grinberg, D., LaCroix, A. Z., Haessler, J., Chasman, D. I., Giulianini, F., Rose, L. M., Ridker, P. M., Eisman, J. A., Nguyen, T. V., Center, J. R., Nogues, X., Garcia-Giralt, N., Launer, L. L., Gudnason, V., Mellström, D., Vandenput, L., Amin, N., Van Duijn, C. M., Karlsson, M. K., Ljunggren, Ö., Svensson, O., Hallmans, G., Rousseau, F., Giroux, S., Bussière, J., Arp, P. P., Koromani, F., Prince, R. L., Lewis, J. R., Langdahl, B. L., Hermann, A. P., Jensen, J. E. B., Kaptoge, S., Khaw, K. T., Reeve, J., Formosa, M. M., Xuereb-Anastasi, A., Åkesson, K., McGuigan, F. E., Garg, G., Olmos, J. M., Zarrabeitia, M. T., Riancho, J. A., Ralston, S. H., Alonso, N., Jiang, X., Goltzman, D., Pastinen, T., Grundberg, E., Gauguier, D., Orwoll, E., Karasik, D., Davey-Smith, G., Smith, A. V., Siggeirsdottir, K., Harris, T. B., Zillikens, M. C., Van Meurs, J. B. J., Thorsteinsdottir, U., Maurano, M. T., Timpson, N. J., Soranzo, N., Durbin, R., Wilson, S. G., Ntzani, E. E., Brown, M. A., Stefansson, K., Hinds, D. A., Spector, T., Cupples, L. A., Ohlsson, C., Greenwood, C. M. T., Jackson, R. D., Rowe, D. W., Loomis, C. A., Evans, D. M., Ackert-Bicknell, C. L., Joyner, A. L., Duncan, E. L., Kiel, D. P., Rivadeneira, F. & Richards, J. B., Oct 1 2015, In : Nature. 526, 7571, p. 112-117 6 p.

Research output: Contribution to journalArticle

Bone Fractures
Bone Density
Genome
Gene Frequency
Population
2014

Analysis Considerations for Utilizing RNA-Seq to Characterize the Brain Transcriptome

Zheng, C., Kawane, S., Bottomly, D. & Wilmot, B., 2014, In : International Review of Neurobiology. 116, p. 21-54 34 p.

Research output: Contribution to journalArticle

RNA Splicing
Untranslated RNA
Alternative Splicing
Transcriptome
Alleles
53 Citations (Scopus)

Functional and genomic context in pathway analysis of GWAS data

Mooney, M., Nigg, J., McWeeney, S. & Wilmot, B., 2014, In : Trends in Genetics. 30, 9, p. 390-400 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Genes
Single Nucleotide Polymorphism
Information Storage and Retrieval
Disease Susceptibility
2 Citations (Scopus)

Oligomask: A framework for assessing and removing the effect of genetic variants on microarray probes

Bottomly, D., Wilmot, B. & McWeeney, S., 2014, In : R Journal. 6, 1, p. 159-163 5 p.

Research output: Contribution to journalArticle

Microarrays
Microarray
Probe
Messenger RNA
Experiment

'Pitfalls in the application of gene set analysis to genetics studies': A response

Mooney, M., Nigg, J., McWeeney, S. & Wilmot, B., Dec 1 2014, In : Trends in Genetics. 30, 12, p. 514-515 2 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Human Genome
Genetic Predisposition to Disease
Genomics
Single Nucleotide Polymorphism
7 Citations (Scopus)
Gene Expression
2013
60 Citations (Scopus)

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Gao, L., Schwartzman, J., Gibbs, A., Lisac, R., Kleinschmidt, R., Wilmot, B., Bottomly, D., Coleman, I., Nelson, P., McWeeney, S. & Alumkal, J., May 21 2013, In : PLoS One. 8, 5, e63563.

Research output: Contribution to journalArticle

Androgen Receptors
prostatic neoplasms
Prostatic Neoplasms
Up-Regulation
Ligands
2 Citations (Scopus)

Change in postprandial substrate oxidation after a high-fructose meal is related to body mass index in healthy men

Smeraglio, A. C., Kennedy, E. K., Horgan, A., Purnell, J. & Gillingham, M., Jun 2013, In : Nutrition Research. 33, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

Fructose
Meals
Body Mass Index
Fats
Glucose
4 Citations (Scopus)
Precision Medicine
Genes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Small Interfering RNA
Genome
17 Citations (Scopus)

Copy number variation analysis in 98 individuals with PHACE syndrome

Siegel, D. H., Shieh, J. T. C., Kwon, E. K., Baselga, E., Blei, F., Cordisco, M., Dobyns, W. B., Duffy, K. J., Garzon, M. C., Gibbs, D. L., Grimmer, J. F., Hayflick, S., Krol, A., Kwok, P. Y., Lorier, R., Matter, A., McWeeney, S., Metry, D., Mitchell, S., Pope, E. & 8 others, Santoro, J. L., Stevenson, D. A., Bayrak-Toydemir, P., Wilmot, B., Worthey, E. A., Frieden, I. J., Drolet, B. A. & Broeckel, U., Mar 2013, In : Journal of Investigative Dermatology. 133, 3, p. 677-684 8 p.

Research output: Contribution to journalArticle

Genes
Defects
Aortic Coarctation
Centromere
Hemangioma
12 Citations (Scopus)

Effects of a high-protein diet on regulation of phosphorus homeostasis

Kremsdorf, R. A., Hoofnagle, A. N., Kratz, M., Weigle, D. S., Callahan, H. S., Purnell, J., Horgan, A., De Boer, I. H. & Kestenbaum, B. R., Mar 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 3, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

Nutrition
Phosphorus
Homeostasis
Diet
Dietary Phosphorus
43 Citations (Scopus)

Genes, behavior and next-generation RNA sequencing

Hitzemann, R., Bottomly, D., Darakjian, P., Walter, N., Iancu, O., Searles, R., Wilmot, B. & McWeeney, S., Feb 2013, In : Genes, Brain and Behavior. 12, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
RNA
Genes
Brain
Untranslated RNA
6 Citations (Scopus)

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J., Eide, C. A., Loriaux, M., Druker, B. & McWeeney, S., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

Prioritization
Genomics
Cancer
Program documentation
Proteins
256 Citations (Scopus)

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B., Loriaux, M., Druker, B. & Tyner, J., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Phosphotransferases
Neoplasms
18 Citations (Scopus)

Protein co-expression network analysis (ProCoNA)

Gibbs, D. L., Baratt, A., Baric, R. S., Kawaoka, Y., Smith, R. D., Orwoll, E., Katze, M. G. & McWeeney, S., Jun 1 2013, In : Journal of Clinical Bioinformatics. 3, 1, 11.

Research output: Contribution to journalArticle

Proteins
Proteomics
Peptides
Gene Ontology
Peptide Mapping
2012
18 Citations (Scopus)

A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates

Lomniczi, A., Garcia-Rudaz, C., Ramakrishnan, R., Wilmot, B., Khouangsathiene, S., Ferguson, B., Dissen, G. & Ojeda, S., Jan 2012, In : Endocrinology. 153, 1, p. 339-349 11 p.

Research output: Contribution to journalArticle

Oligomenorrhea
Amenorrhea
Primates
Single Nucleotide Polymorphism
Periodicity
6 Citations (Scopus)

Children with severe early childhood caries: Pilot study examining mutans streptococci genotypic strains after full-mouth caries restorative therapy

Palmer, E. A., Nielsen, T., Peirano, P., Nguyen, A. T., Vo, A., Nguyen, A., Jackson, S., Finlayson, T., Sauerwein, R., Marsh, K., Edwards, I., Wilmot, B., Engle, J., Peterson, J., Maier, T. & Machida, C., Mar 2012, In : Pediatric Dentistry. 34, 2

Research output: Contribution to journalArticle

Streptococcus mutans
Mouth
Streptococcus
Therapeutics
Polymerase Chain Reaction
11 Citations (Scopus)

Heritability of serum sodium concentration: Evidence for sex- and ethnic-specific effects

Wilmot, B., Saroja Voruganti, V., Chang, Y. P. C., Fu, Y., Chen, Z., Taylor, H. A., Wilson, J. G., Gipson, T., Shah, V. O., Umans, J. G., Flessner, M. F., Hitzemann, R., Shuldiner, A. R., Comuzzie, A. G., McWeeney, S., Zager, P. G., Maccluer, J. W., Cole, S. A. & Cohen, D., Feb 2012, In : Physiological Genomics. 44, 3, p. 220-228 9 p.

Research output: Contribution to journalArticle

North American Indians
Sodium
Serum
Glomerular Filtration Rate
Glucose
30 Citations (Scopus)

Practices and perspectives on building integrated data repositories: Results from a 2010 CTSA survey

MacKenzie, S. L., Wyatt, M. C., Schuff, R., Tenenbaum, J. D. & Anderson, N., Jun 2012, In : Journal of the American Medical Informatics Association. 19, E1

Research output: Contribution to journalArticle

Research
Organizations
Research Subjects
Informatics
Translational Medical Research
13 Citations (Scopus)
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genes
Genetic algorithms
Genetic Algorithm
2011
13 Citations (Scopus)

A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer

Schwartzman, J., Mongoue-Tchokote, S., Gibbs, A., Gao, L., Corless, C., Jin, J., Zarour, L., Higano, C., True, L. D., Vessella, R. L., Wilmot, B., Bottomly, D., McWeeney, S., Bova, S. G., Partin, A. W., Mori, M. T. & Alumkal, J., Oct 2011, In : Epigenetics. 6, 10, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Oligonucleotide Array Sequence Analysis
Prostatic Neoplasms
Genes
Prostate
4 Citations (Scopus)

Microcephaly genes and risk of late-onset Alzheimer disease

Erten-Lyons, D., Wilmot, B., Anur, P., McWeeney, S., Westaway, S., Silbert, L., Kramer, P. & Kaye, J., Jul 2011, In : Alzheimer Disease and Associated Disorders. 25, 3, p. 276-282 7 p.

Research output: Contribution to journalArticle

Microcephaly
Alzheimer Disease
Genes
Brain
Genetic Models
2010
79 Citations (Scopus)

A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

McWeeney, S., Pemberton, L. C., Loriaux, M., Vartanian, K., Willis, S. G., Yochum, G., Wilmot, B., Turpaz, Y., Pillai, R., Druker, B., Snead, J. L., MacPartlin, M., O'Brien, S. G., Melo, J. V., Lange, T., Harrington, C. C. & Deininger, M. W. N., Jan 14 2010, In : Blood. 115, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic Phase
Transcriptome
Gene expression
Cytogenetics
Classifiers
2009
67 Citations (Scopus)

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R., Hitzemann, R., Orwoll, E., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Hyponatremia
Sodium
Alleles
Osmotic Pressure