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2019

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S. K., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. J. & Tyner, J. W., Dec 1 2019, In : Nature communications. 10, 1, 244.

Research output: Contribution to journalArticle

23 Scopus citations

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Zhang, H., Wilmot, B., Bottomly, D., Dao, K-H., Stevens, E., Eide, C. A., Khanna, V., Rofelty, A., Savage, S., Schultz, A. R., Long, N., White, L., Carlos, A., Henson, R., Lin, C., Searles, R., Collins, R. H., DeAngelo, D. J., Deininger, M. W., Dunn, T. & 12 others, Hein, T., Luskin, M. R., Medeiros, B. C., Oh, S. T., Pollyea, D. A., Steensma, D. P., Stone, R. M., Druker, B., McWeeney, S., Maxson, J. E., Gotlib, J. R. & Tyner, J., Sep 12 2019, In : Blood. 134, 11, p. 867-879 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunological Molecular Responses of Human Retinal Pigment Epithelial Cells to Infection With Toxoplasma gondii

Lie, S., Rochet, E., Segerdell, E., Ma, Y., Ashander, L. M., Shadforth, A. M. A., Blenkinsop, T. A., Michael, M. Z., Appukuttan, B., Wilmot, B. & Smith, J. R., 2019, In : Frontiers in immunology. 10, p. 708 1 p., 708.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Oral Vitamin C (500 mg/d) to pregnant smokers improves infant airway function at 3 months (VCSIP) a randomized trial

McEvoy, C. T., Shorey-Kendrick, L. E., Milner, K., Schilling, D., Tiller, C., Vuylsteke, B., Scherman, A., Jackson, K., Haas, D. M., Harris, J., Schuff, R., Park, B. S., Vu, A., Kraemer, D. F., Mitchell, J., Metz, J., Gonzales, D., Bunten, C., Spindel, E. R., Tepper, R. S. & 1 others, Morris, C. D., May 1 2019, In : American journal of respiratory and critical care medicine. 199, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Polymorphisms in oxidative stress pathway genes and prostate cancer risk

Zhang, Z., Jiang, D., Wang, C., Garzotto, M., Kopp, R., Wilmot, B., Thuillier, P., Dang, A., Palma, A., Farris, P. E. & Shannon, J., Dec 1 2019, In : Cancer Causes and Control. 30, 12, p. 1365-1375 11 p.

Research output: Contribution to journalArticle

2018

Analysis of shared heritability in common disorders of the brain

The Brainstorm Consortium, Jun 22 2018, In : Science. 360, 6395, 8757.

Research output: Contribution to journalArticle

386 Scopus citations

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

132 Scopus citations

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O. D., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. C., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J. E., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E. R., Bottomly, D., McWeeney, S. K., Wilmot, B., Loriaux, M., Chang, B. H. & Tyner, J. W., Jul 17 2018, In : Science signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

1 Scopus citations
22 Scopus citations
2017

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. K. & Tyner, J. W., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics

for the Osteoporotic Fractures in Men (MrOS) Study Research Group, Jul 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

NFAT5 and SLC4A10 loci associate with plasma osmolality

Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P. & 86 others, Cucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C. M., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E. S., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
17 Scopus citations

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Zhang, H., Means, S., Schultz, A. R., Watanabe-Smith, K., Medeiros, B. C., Bottomly, D., Wilmot, B., McWeeney, S. K., Kükenshöner, T., Hantschel, O. & Tyner, J. W., Aug 15 2017, In : Cancer Research. 77, 16, p. 4258-4267 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health

McEvoy, C. T., Milner, K. F., Scherman, A. J., Schilling, D. G., Tiller, C. J., Vuylsteke, B., Shorey-Kendrick, L. E., Spindel, E. R., Schuff, R., Mitchell, J., Peters, D., Metz, J., Haas, D., Jackson, K., Tepper, R. S. & Morris, C. D., Jul 1 2017, In : Contemporary Clinical Trials. 58, p. 66-77 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

HitWalker2: Visual analytics for precision medicine and beyond

Bottomly, D., McWeeney, S. K. & Wilmot, B., Apr 15 2016, In : Bioinformatics. 32, 8, p. 1253-1255 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J. E., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S. K., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. J. & Tyner, J. W., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2

Wilmot, B., Fry, R., Smeester, L., Musser, E. D., Mill, J. & Nigg, J. T., Feb 1 2016, In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 57, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach

IMAGE2 Consortium & German ADHD GWAS Group, Sep 1 2016, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 171, 6, p. 815-826 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Gene set analysis: A step-by-step guide

Mooney, M. A. & Wilmot, B., Oct 1 2015, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 168, 7, p. 517-527 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status: A pilot study

Hall, T. A., Steiner, R. D., Wright, H., Wilmot, B., Roullet, J. B., Peters, M. & Harris, M., Sep 1 2015, In : New Horizons in Translational Medicine. 2, 6-7, p. 137-146 10 p.

Research output: Contribution to journalArticle

plethy: Management of whole body plethysmography data in R

Bottomly, D., Wilmot, B. & McWeeney, S. K., Dec 12 2015, In : BMC bioinformatics. 16, 1, 134.

Research output: Contribution to journalArticle

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Lue, H. W., Cole, B., Rao, S. A. M., Podolak, J., Van Gaest, A., King, C., Eide, C. A., Wilmot, B., Xue, C., Spellman, P. T., Heiser, L. M., Tyner, J. W. & Thomas, G. V., 2015, In : Oncotarget. 6, 42, p. 44675-44687 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Oligomask: A framework for assessing and removing the effect of genetic variants on microarray probes

Bottomly, D., Wilmot, B. & McWeeney, S. K., 2014, In : R Journal. 6, 1, p. 159-163 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Gao, L., Schwartzman, J., Gibbs, A., Lisac, R., Kleinschmidt, R., Wilmot, B., Bottomly, D., Coleman, I., Nelson, P., McWeeney, S. & Alumkal, J., May 21 2013, In : PloS one. 8, 5, e63563.

Research output: Contribution to journalArticle

74 Scopus citations

Change in postprandial substrate oxidation after a high-fructose meal is related to body mass index in healthy men

Smeraglio, A. C., Kennedy, E. K., Horgan, A., Purnell, J. Q. & Gillingham, M. B., Jun 1 2013, In : Nutrition Research. 33, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Copy number variation analysis in 98 individuals with PHACE syndrome

Siegel, D. H., Shieh, J. T. C., Kwon, E. K., Baselga, E., Blei, F., Cordisco, M., Dobyns, W. B., Duffy, K. J., Garzon, M. C., Gibbs, D. L., Grimmer, J. F., Hayflick, S. J., Krol, A. L., Kwok, P. Y., Lorier, R., Matter, A., McWeeney, S., Metry, D., Mitchell, S., Pope, E. & 8 others, Santoro, J. L., Stevenson, D. A., Bayrak-Toydemir, P., Wilmot, B., Worthey, E. A., Frieden, I. J., Drolet, B. A. & Broeckel, U., Mar 2013, In : Journal of Investigative Dermatology. 133, 3, p. 677-684 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Effects of a high-protein diet on regulation of phosphorus homeostasis

Kremsdorf, R. A., Hoofnagle, A. N., Kratz, M., Weigle, D. S., Callahan, H. S., Purnell, J. Q., Horgan, A. M., De Boer, I. H. & Kestenbaum, B. R., Mar 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 3, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

HitWalker: Variant prioritization for personalized functional cancer genomics

Bottomly, D., Wilmot, B., Tyner, J. W., Eide, C. A., Loriaux, M. M., Druker, B. J. & McWeeney, S. K., Feb 15 2013, In : Bioinformatics. 29, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

Protein co-expression network analysis (ProCoNA)

Gibbs, D. L., Baratt, A., Baric, R. S., Kawaoka, Y., Smith, R. D., Orwoll, E. S., Katze, M. G. & McWeeney, S. K., Jun 1 2013, In : Journal of Clinical Bioinformatics. 3, 1, 11.

Research output: Contribution to journalArticle

18 Scopus citations
2012

A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates

Lomniczi, A., Garcia-Rudaz, C., Ramakrishnan, R., Wilmot, B., Khouangsathiene, S., Ferguson, B., Dissen, G. A. & Ojeda, S. R., Jan 2012, In : Endocrinology. 153, 1, p. 339-349 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Children with severe early childhood caries: Pilot study examining mutans streptococci genotypic strains after full-mouth caries restorative therapy

Palmer, E. A., Nielsen, T., Peirano, P., Nguyen, A. T., Vo, A., Nguyen, A., Jackson, S., Finlayson, T., Sauerwein, R., Marsh, K., Edwards, I., Wilmot, B., Engle, J., Peterson, J., Maier, T. & Machida, C. A., Mar 1 2012, In : Pediatric dentistry. 34, 2, p. E1-E10

Research output: Contribution to journalArticle

6 Scopus citations

Practices and perspectives on building integrated data repositories: Results from a 2010 CTSA survey

MacKenzie, S. L., Wyatt, M. C., Schuff, R., Tenenbaum, J. D. & Anderson, N., Jun 2012, In : Journal of the American Medical Informatics Association. 19, E1, p. e119-e124

Research output: Contribution to journalArticle

34 Scopus citations
2009

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R. F., Hitzemann, R., Orwoll, E. S., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D. M., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

70 Scopus citations
2007

The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells

Obara, Y., Horgan, A. M. & Stork, P. J. S., Apr 1 2007, In : Journal of neurochemistry. 101, 2, p. 470-482 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2006

Prospective evaluation of the relationship between C-reactive protein, D-dimer and progression of peripheral arterial disease

Musicant, S. E., Taylor, L. M., Peters, D., Schuff, R. A., Urankar, R., Landry, G. J. & Moneta, G. L., Apr 2006, In : Journal of vascular surgery. 43, 4, p. 772-780 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2004

Distribution, type and origin of Parkin mutations: Review and case studies

Hedrich, K., Eskelson, C., Wilmot, B., Marder, K., Harris, J., Garrels, J., Meija-Santana, H., Vieregge, P., Jacobs, H., Bressman, S. B., Lang, A. E., Kann, M., Abbruzzese, G., Martinelli, P., Schwinger, E., Ozelius, L. J., Pramstaller, P. P., Klein, C. & Kramer, P., Oct 2004, In : Movement Disorders. 19, 10, p. 1146-1157 12 p.

Research output: Contribution to journalArticle

170 Scopus citations
2003

Examining the mechanism of Erk nuclear translocation using green fluorescent protein

Horgan, A. M. & Stork, P. J. S., May 1 2003, In : Experimental Cell Research. 285, 2, p. 208-220 13 p.

Research output: Contribution to journalArticle

51 Scopus citations
2002
39 Scopus citations
2000

Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase

Grewal, S. S., Horgan, A. M., York, R. D., Withers, G. S., Banker, G. A. & Stork, P. J. S., Feb 4 2000, In : Journal of Biological Chemistry. 275, 5, p. 3722-3728 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Pallido-luysio-nigral atrophy revealed by rapidly progressive hemidystonia: A clinical, radiologic, functional, and neuropathologic study

Nutt, J. G., Lea, E. S., Van Houten, L., Schuff, R. A. & Sexton, G. J., 2000, In : Movement Disorders. 15, 5, p. 947-953 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
1999

Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease

Taylor, J., Moneta, G. L., Sexton, G. J., Schuff, R. A., Porter, J. M., Bassiouny, H. S., Whittemore, A. D., Brantigan, C. O., Killewich, L. A., Wolfe, J. H. N., Dalman, R. L., Harris, J., Park, T., DeFrang, R. D., Masser, P. A., Lee, R. W., Nehler, M. R., McClafferty, R. B., Landry, G. L., Whitaker, L. & 8 others, LoBoa, L., Kelly, H., Otto, J., Wilson, D., Percy, D., McAnulty, J. H., Nutt, J. G. & Sack, R. L., Jan 1 1999, In : Journal of vascular surgery. 29, 1, p. 8-21 14 p.

Research output: Contribution to journalArticle

175 Scopus citations
1998

G protein-mediated inhibition of neuronal migration requires calcium influx

Horgan, A. M. & Copenhaver, P. F., Jun 1 1998, In : Journal of Neuroscience. 18, 11, p. 4189-4200 12 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
1995

A developmental role for the heterotrimeric G protein Goα in a migratory population of embryonic neurons

Horgan, A. M., Lagrange, M. T. & Copenhaver, P. F., Jan 1 1995, In : Developmental Biology. 172, 2, p. 640-653 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Developmental expression of heterotrimeric G proteins in the nervous system of Manduca sexta

Copenhaver, P. F., Horgan, A. M., Nichols, D. C. & Rasmussen, M. A., Apr 1995, In : Journal of Neurobiology. 26, 4, p. 461-484 24 p.

Research output: Contribution to journalArticle

10 Scopus citations

Manufacturers' distribution of drug samples to a family medicine clinic

Haxby, D. G., Rodriguez, G. S., Zechnich, A. D., Schuff, R. A. & Tanigawa, J. S., 1995, In : American Journal of Health-System Pharmacy. 52, 5, p. 496-499 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
1994

Developmental expression of G proteins in a migratory population of embryonic neurons

Horgan, A. M., Lagrange, M. T. & Copenhaver, P. F., Apr 1 1994, In : Development. 120, 4, p. 729-742 14 p.

Research output: Contribution to journalArticle

18 Scopus citations