Research Output

Filter
Article
2010

Chemical genetics of Plasmodium falciparum

Guiguemde, W. A., Shelat, A. A., Bouck, D., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J., Zhu, F., Jiménez-Díaz, M. B., Martinez, M. S., Wilson, E. B., Tripathi, A. K., Gut, J., Sharlow, E. R., Bathurst, I., Mazouni, F. E., Fowble, J. W., Forquer, I. & 15 others, McGinley, P. L., Castro, S., Angulo-Barturen, I., Ferrer, S., Rosenthal, P. J., Derisi, J. L., Sullivan, D. J., Lazo, J. S., Roos, D. S., Riscoe, M. K., Phillips, M. A., Rathod, P. K., Van Voorhis, W. C., Avery, V. M. & Guy, R. K., May 20 2010, In : Nature. 465, 7296, p. 311-315 5 p.

Research output: Contribution to journalArticle

405 Scopus citations

CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice

Gresack, J., Powell, S., Geyer, M., Poore, M. S., Coste, S. & Risbrough, V., Aug 1 2010, In : Neuropeptides. 44, 4, p. 349-353 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells

Snyder, C. M., Allan, J. E., Bonnett, E. L., Doom, C. M. & Hill, A. B., Mar 12 2010, In : PloS one. 5, 3, e9681.

Research output: Contribution to journalArticle

51 Scopus citations

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity

Eghtesad, S., Zheng, H., Nakai, H., Epperly, M. W. & Clemens, P. R., Sep 1 2010, In : Gene therapy. 17, 9, p. 1181-1190 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Glucose transporters in parasitic protozoa.

Landfear, S. M., 2010, In : Methods in molecular biology (Clifton, N.J.). 637, p. 245-262 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human cytomegalovirus TR strain glycoprotein O acts as a chaperone promoting gH/gL incorporation into virions but is not present in virions

Ryckman, B. J., Chase, M. C. & Johnson, D. C., Mar 1 2010, In : Journal of virology. 84, 5, p. 2597-2609 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1

Quintela-Fandino, M., Arpaia, E., Brenner, D., Goh, T., Yeung, F. A., Blaser, H., Alexandrova, R., Lind, E. F., Tusche, M. W., Wakeham, A., Ohashi, P. S. & Mak, T. W., Feb 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2622-2627 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors

Gresack, J. E., Risbrough, V. B., Scott, C. N., Coste, S., Stenzel-Poore, M., Geyer, M. A. & Powell, S. B., May 1 2010, In : Behavioural Brain Research. 209, 1, p. 80-84 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major

Ortiz, D., Valdés, R., Sanchez, M. A., Hayenga, J., Elya, C., Detke, S. & Landfear, S. M., Oct 1 2010, In : Molecular Microbiology. 78, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Roles of Arabidopsis patatin-related phospholipases a in root development are related to auxin responses and phosphate deficiency

Rietz, S., Dermendjiev, G., Oppermann, E., Tafesse, F. G., Effendi, Y., Holk, A., Parker, J. E., Teige, M. & Scherer, G. F. E., May 2010, In : Molecular Plant. 3, 3, p. 524-538 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

Dikeakos, J. D., Atkins, K. M., Thomas, L., Emert-Sedlak, L., Byeon, I. J. L., Jung, J., Ahn, J., Wortman, M. D., Kukull, B., Saito, M., Koizumi, H., Williamson, D. M., Hiyoshi, M., Barklis, E., Takiguchi, M., Suzu, S., Gronenborn, A. M., Smithgall, T. E. & Thomas, G., Oct 1 2010, In : Molecular biology of the cell. 21, 19, p. 3279-3292 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase

Nice, T. J., Deng, W., Coscoy, L. & Raulet, D. H., Nov 1 2010, In : Journal of Immunology. 185, 9, p. 5369-5376 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis

Zeng, S. X., Li, Y., Jin, Y., Zhang, Q., Keller, D. M., McQuaw, C. M., Barklis, E., Stone, S., Hoatlin, M., Zhao, Y. & Lu, H., Feb 1 2010, In : Molecular and cellular biology. 30, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice

Deng, G. M., Liu, L., Bahjat, F. R., Pine, P. R. & Tsokos, G. C., Jul 1 2010, In : Arthritis and rheumatism. 62, 7, p. 2086-2092 7 p.

Research output: Contribution to journalArticle

104 Scopus citations
2009

Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with Andes virus

Safronetz, D., Hegde, N. R., Ebihara, H., Denton, M., Kobinger, G. P., St. Jeor, S., Feldmann, H. & Johnson, D. C., Jul 1 2009, In : Journal of virology. 83, 14, p. 7285-7295 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

McKee, A. S., Munks, M. W., MacLeod, M. K. L., Fleenor, C. J., Van Rooijen, N., Kappler, J. W. & Marrack, P., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4403-4414 12 p.

Research output: Contribution to journalArticle

245 Scopus citations

Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Buffalo, C., Bouwer, H. G. A., Kruvand, E., Beverley, S. M. & Landfear, S. M., Jan 1 2009, In : Molecular Microbiology. 71, 2, p. 369-381 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

An ab initio structural model of a nucleoside permease predicts functionally important residues

Valdés, R., Arastu-Kapur, S., Landfear, S. M. & Shinde, U., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19067-19076 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

An acid-activated nucleobase transporter from Leishmania major

Ortiz, D., Sanchez, M. A., Koch, H. P., Larson, H. P. & Landfear, S. M., Jun 12 2009, In : Journal of Biological Chemistry. 284, 24, p. 16164-16169 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids

Alfadhli, A., Still, A. & Barklis, E., Dec 1 2009, In : Journal of virology. 83, 23, p. 12196-12203 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

A new model of cortical stroke in the rhesus macaque

West, G. A., Golshani, K. J., Doyle, K. P., Lessov, N. S., Hobbs, T. R., Kohama, S. G., Pike, M. M., Kroenke, C. D., Grafe, M. R., Spector, M. D., Tobar, E. T., Simon, R. P. & Stenzel-Poore, M. P., Jun 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 6, p. 1175-1186 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Anti-candida activity of α-melanocyte-stimulating hormone (α-MSH) peptides

Rauch, I., Holzmeister, S. & Kofler, B., Mar 1 2009, In : Journal of Leukocyte Biology. 85, 3, p. 371-372 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Arsenic transport by zebrafish aquaglyceroporins

Hamdi, M., Sanchez, M. A., Beene, L. C., Liu, Q., Landfear, S. M., Rosen, B. P. & Liu, Z., Nov 25 2009, In : BMC Molecular Biology. 10, 104.

Research output: Contribution to journalArticle

51 Scopus citations

CD4+ T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine cytomegalovirus infection

Snyder, C. M., Loewendorf, A., Bonnett, E. L., Croft, M., Benedict, C. A. & Hill, A. B., Sep 15 2009, In : Journal of Immunology. 183, 6, p. 3932-3941 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Characterization of the In Vitro HIV-1 Capsid Assembly Pathway

Barklis, E., Alfadhli, A., McQuaw, C., Yalamuri, S., Still, A., Barklis, R. L., Kukull, B. & López, C. S., Mar 27 2009, In : Journal of molecular biology. 387, 2, p. 376-389 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting

Stengel, A., Goebel, M., Million, M., Stenzel-Poore, M. P., Kobelt, P., Mönnikes, H., Taché, Y. & Wang, L., Jan 1 2009, In : Endocrinology. 150, 1, p. 153-160 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

CRF 1 and CRF 2 receptors are required for potentiated startle to contextual but not discrete cues

Risbrough, V. B., Geyer, M. A., Hauger, R. L., Coste, S., Stenzel-Poore, M., Wurst, W. & Holsboer, F., May 1 2009, In : Neuropsychopharmacology. 34, 6, p. 1494-1503 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

CRF enhancement of GIRK channel-mediated transmission in dopamine neurons

Beckstead, M. J., Gantz, S. C., Ford, C. P., Stenzel-Poore, M. P., Phillips, P. E. M., Mark, G. P. & Williams, J. T., Jul 1 2009, In : Neuropsychopharmacology. 34, 8, p. 1926-1935 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides

Purdy, G. E., Niederweis, M. & Russell, D. G., Sep 1 2009, In : Molecular Microbiology. 73, 5, p. 844-857 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells

Krishnan, S., Juang, Y. T., Chowdhury, B., Magilavy, A., Fisher, C. U., Nguyen, H., Nambiar, M. P., Kyttaris, V., Weinstein, A., Bahjat, R., Pine, P., Rus, V. & Tsokos, G. C., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 8145-8152 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Discovery of dual function acridones as a new antimalarial chemotype

Kelly, J. X., Smilkstein, M. J., Brun, R., Wittlin, S., Cooper, R. A., Lane, K. D., Janowsky, A., Johnson, R. A., Dodean, R. A., Winter, R., Hinrichs, D. J. & Riscoe, M. K., May 14 2009, In : Nature. 459, 7244, p. 270-273 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculature

Schmidhuber, S. M., Rauch, I., Kofler, B. & Brain, S. D., Feb 1 2009, In : Journal of Molecular Neuroscience. 37, 2, p. 177-181 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB

Wright, C. C., Wisner, T. W., Hannah, B. P., Eisenberg, R. J., Cohen, G. H. & Johnson, D. C., Nov 1 2009, In : Journal of virology. 83, 22, p. 11847-11856 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase

Wisner, T. W., Wright, C. C., Kato, A., Kawaguchi, Y., Mou, F., Baines, J. D., Roller, R. J. & Johnson, D. C., Apr 1 2009, In : Journal of virology. 83, 7, p. 3115-3126 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate

Alfadhli, A., Barklis, R. L. & Barklis, E., May 10 2009, In : Virology. 387, 2, p. 466-472 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

Blume, M., Rodriguez-Contreras, D., Landfear, S., Fleige, T., Soldati-Favre, D., Lucius, R. & Gupta, N., Aug 4 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12998-13003 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Inflammation and the emerging role of the toll-like receptor system in acute brain ischemia

Marsh, B. J., Stevens, S. L., Hunter, B. & Stenzel-Poore, M. P., Mar 1 2009, In : Stroke. 40, 3 SUPPL. 1, p. S34-S37

Research output: Contribution to journalArticle

37 Scopus citations

Investigation of the impact of the common animal facility contaminant murine norovirus on experimental murine cytomegalovirus infection

Doom, C. M., Turula, H. M. & Hill, A. B., Sep 30 2009, In : Virology. 392, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo

Wood, W. J. L., Geraci, T., Nilsen, A., DeBarber, A. E. & Scanlan, T. S., Jan 26 2009, In : ChemBioChem. 10, 2, p. 361-365 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Ly49P recognition of cytomegalovirus-infected cells expressing H2-D k and CMV-encoded m04 correlates with the NK cell antiviral response

Kielczewska, A., Pyzik, M., Sun, T., Krmpotic, A., Lodoen, M. B., Munks, M. W., Babic, M., Hill, A. B., Koszinowski, U. H., Jonjic, S., Lanier, L. L. & Vidal, S. M., Mar 16 2009, In : Journal of Experimental Medicine. 206, 3, p. 515-523 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Neural regulation of immunity: Role of NPR-1 in pathogen avoidance and regulation of innate immunity

Aballay, A., Apr 1 2009, In : Cell Cycle. 8, 7, p. 966-969 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Kamizono, S., Duncan, G. S., Seidel, M. G., Morimoto, A., Hamada, K., Grosveld, G., Akashi, K., Lind, E. F., Haight, J. P., Ohashi, P. S., Look, A. T. & Mak, T. W., Dec 21 2009, In : Journal of Experimental Medicine. 206, 13, p. 2977-2986 10 p.

Research output: Contribution to journalArticle

206 Scopus citations

Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1

Fuhrman, L. E., Goel, A. K., Smith, J., Shianna, K. V. & Aballay, A., Sep 1 2009, In : PLoS genetics. 5, 9, e1000657.

Research output: Contribution to journalArticle

41 Scopus citations

Plasma adiponectin levels are increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome

Shinahara, M., Nishiyama, M., Iwasaki, Y., Nakayama, S., Noguchi, T., Kambayashi, M., Okada, Y., Tsuda, M., Stenzel-Poore, M. P., Hashimoto, K. & Terada, Y., Nov 9 2009, In : Endocrine Journal. 56, 7, p. 879-886 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Posttranslational regulation of the NKG2D ligand Multl in response to cell stress

Nice, T. J., Coscoy, L. & Raulet, D. H., Feb 16 2009, In : Journal of Experimental Medicine. 206, 2, p. 287-298 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Rapidly evolving adeno-associated virus vectors: Increasing possibility of gene therapy with custom-made vectors

Nakai, H., Dec 1 2009, In : Drug Delivery System. 24, 6, p. 582-591 10 p.

Research output: Contribution to journalArticle

Regulation of DAF-16-mediated innate immunity in Caenorhabditis elegans

Singh, V. & Aballay, A., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35580-35587 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Severe dengue epidemics in Sri Lanka, 2003-2006

Kanakaratne, N., Wahala, W. M. P. B., Messer, W. B., Tissera, H. A., Shahani, A., Abeysinghe, N., De Silva, A. M. & Gunasekera, M., Feb 1 2009, In : Emerging infectious diseases. 15, 2, p. 192-199 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide

Flythe, J. E., Rueda, J. F., Riscoe, M. K. & Watnick, S., Jul 1 2009, In : American Journal of Kidney Diseases. 54, 1, p. 127-130 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

Vacaru, A. M., Tafesse, F. G., Ternes, P., Kondylis, V., Hermansson, M., Brouwers, J. F. H. M., Somerharju, P., Rabouille, C. & Holthuis, J. C. M., Jun 15 2009, In : Journal of Cell Biology. 185, 6, p. 1013-1027 15 p.

Research output: Contribution to journalArticle

101 Scopus citations