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2013

Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in Trans acting as the viral fusion protein rather than as a receptor-binding protein

Wille, P. T., Wisner, T. W., Ryckman, B. & Johnson, D. C., May 1 2013, In : mBio. 4, 3

Research output: Contribution to journalArticle

50 Scopus citations

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Tafesse, F. G., Sanyal, S., Ashour, J., Guimaraes, C. P., Hermansson, M., Somerharju, P. & Ploegh, H. L., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6406-6411 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats

Yu, H., Fischer, G., Ferhatovic, L., Fan, F., Light, A. R., Weihrauch, D., Sapunar, D., Nakai, H., Park, F. & Hogan, Q. H., Apr 16 2013, In : PloS one. 8, 4, e61266.

Research output: Contribution to journalArticle

20 Scopus citations

KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes

Tran, K. D., Rodriguez-Contreras, D., Vieira, D. P., Yates, P. A., David, L., Beatty, W., Elferich, J. & Landfear, S. M., Aug 2 2013, In : Journal of Biological Chemistry. 288, 31, p. 22721-22733 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Micro-RNA 155 Is required for Optimal CD8+ T Cell responses to acute viral and intracellular bacterial challenges

Lind, E. F., Elford, A. R. & Ohashi, P. S., Feb 1 2013, In : Journal of Immunology. 190, 3, p. 1210-1216 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis

Pacheco, S. A., Hsu, F. F., Powers, K. M. & Purdy, G. E., Aug 16 2013, In : Journal of Biological Chemistry. 288, 33, p. 24213-24222 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Molecular identification and characterization of an essential pyruvate transporter from trypanosoma brucei

Sanchez, M. A., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14428-14437 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pathogen-Specific Inflammatory Milieux Tune the Antigen Sensitivity of CD8+ T Cells by Enhancing T Cell Receptor Signaling

Richer, M. J., Nolz, J. C. & Harty, J. T., Jan 24 2013, In : Immunity. 38, 1, p. 140-152 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

Peripheral CD4+ T-cell tolerance is induced in vivo by rare antigen-bearing B cells in follicular, marginal zone, and B-1 subsets

Murray, S. E., Toren, K. G. & Parker, D. C., Jul 1 2013, In : European Journal of Immunology. 43, 7, p. 1818-1827 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Quinolone-3-diarylethers: A new class of antimalarial drug

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., Mather, M. W., Delves, M. J., Shackleford, D. M., Saenz, F. E., Morrisey, J. M., Steuten, J., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A. M. & 21 others, Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jiménez-Díaz, M. B., Ferrer, S., Herreros, E., Sanz, L. M., Gamo, F. J., Bathurst, I., Burrows, J. N., Siegl, P., Guy, R. K., Winter, R. W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. & Riscoe, M. K., Mar 20 2013, In : Science translational medicine. 5, 177, 177ra37.

Research output: Contribution to journalArticle

124 Scopus citations
18 Scopus citations

Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes

Kernbauer, E., Maier, V., Rauch, I., Müller, M. & Decker, T., Jun 19 2013, In : PloS one. 8, 6, e65007.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein

López, C. S., Tsagli, S. M., Sloan, R., Eccles, J. & Barklis, E., Dec 1 2013, In : Virology. 447, 1-2, p. 95-103 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of leishmania donovani pyrimidine auxotrophs

Soysa, R., Wilson, Z. N., Elferich, J., Forquer, I., Shinde, U., Riscoe, M. K., Yates, P. A. & Ullman, B., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29954-29964 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1

Zhou, Y., Austin, S. K., Fremont, D. H., Yount, B. L., Huynh, J. P., de Silva, A. M., Baric, R. S. & Messer, W. B., Apr 25 2013, In : Virology. 439, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tractable mammalian cell infections with protozoan-primed bacteria

Drennan, S. L., Lama, A., Doron, B. & Cambronne, E., Jan 1 2013, In : Journal of visualized experiments : JoVE. 74

Research output: Contribution to journalArticle

1 Scopus citations

'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana

Feng, X., Rodriguez-Contreras, D., Polley, T., Lye, L. F., Scott, D., Burchmore, R. J. S., Beverley, S. M. & Landfear, S. M., Jan 1 2013, In : Molecular Microbiology. 87, 2, p. 412-429 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Virulence profile: Alejandro Aballay

Aballay, A., Jan 1 2013, In : Virulence. 4, 7, p. 638-640 3 p.

Research output: Contribution to journalArticle

2012

AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence

Wang, Z., Lisowski, L., Finegold, M. J., Nakai, H., Kay, M. A. & Grompe, M., Oct 1 2012, In : Molecular Therapy. 20, 10, p. 1902-1911 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Adeno-associated virus serotype 8 (AAV8) delivery of recombinant A20 to skeletal muscle reduces pathological Activation of Nuclear Factor (NF)-κB in muscle of mdx mice

Charan, R. A., Niizawa, G., Nakai, H. & Clemens, P. R., Nov 6 2012, In : Molecular Medicine. 18, 12, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Both sequence and context are important for flagellar targeting of a glucose transporter

Tran, K. D., Rodriguez-Contreras, D., Shinde, U. & Landfear, S. M., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3293-3298 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Changes in Spontaneous Activity Assessed by Accelerometry Correlate with Extent of Cerebral Ischemia-Reperfusion Injury in the Nonhuman Primate

Urbanski, H. F., Kohama, S. G., West, G. A., Glynn, C., Williams-Karnesky, R. L., Earl, E., Neuringer, M. N., Renner, L., Weiss, A., Stenzel-Poore, M. & Bahjat, F. R., Dec 1 2012, In : Translational Stroke Research. 3, 4, p. 442-451 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chronic viral infections and immunosenescence, with a focus on CMV

Tatum, A. M. & Hill, A., Jul 23 2012, In : Open Longevity Science. 6, p. 33-38 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

CMV and Immunosenescence: From basics to clinics

Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Cicin-Sain, L., Derhovanessian, E., Ferrando-Martínez, S., Frasca, D., Fulöp, T., Govind, S., Grubeck-Loebenstein, B., Hill, A., Hurme, M., Kern, F., Larbi, A. & 17 others, López-Botet, M., Maier, A. B., McElhaney, J. E., Moss, P., Naumova, E., Nikolich-Zugich, J., Pera, A., Rector, J. L., Riddell, N., Sanchez-Correa, B., Sansoni, P., Sauce, D., van Lier, R., Wang, G. C., Wills, M. R., Zieliński, M. & Pawelec, G., Oct 31 2012, In : Immunity and Ageing. 9, 23.

Research output: Contribution to journalArticle

94 Scopus citations
45 Scopus citations

Cysteine cross-linking defines the extracellular gate for the Leishmania donovani nucleoside transporter 1.1 (LdNT1.1)

Valdés, R., Shinde, U. & Landfear, S. M., Dec 28 2012, In : Journal of Biological Chemistry. 287, 53, p. 44036-44045 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization

Messer, W. B., Yount, B., Hacker, K. E., Donaldson, E. F., Huynh, J. P., de Silva, A. M. & Baric, R. S., Feb 1 2012, In : PLoS neglected tropical diseases. 6, 2, e1486.

Research output: Contribution to journalArticle

45 Scopus citations
12 Scopus citations

Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells

Nolz, J. C., Rai, D., Badovinac, V. P. & Harty, J. T., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6199-6204 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells

Chatterjee, S., Seifried, L., Feigin, M. E., Gibbons, D. L., Scuoppo, C., Lin, W., Rizvi, Z. H., Lind, E., Dissanayake, D., Kurie, J., Ohashi, P. & Muthuswamy, S. K., Apr 18 2012, In : PloS one. 7, 4, e34343.

Research output: Contribution to journalArticle

22 Scopus citations

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Doggett, J. S., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordón, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J. N., Hinrichs, D. J., Meunier, B., Carruthers, V. B. & Riscoe, M. K., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39, p. 15936-15941 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1

Singh, V. & Aballay, A., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33191-33197 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identification and validation of ifit1 as an important innate immune bottleneck

McDermott, J. E., Vartanian, K. B., Mitchell, H., Stevens, S. L., Sanfilippo, A. & Stenzel-Poore, M. P., Jun 20 2012, In : PloS one. 7, 6, e36465.

Research output: Contribution to journalArticle

17 Scopus citations

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

De Alwis, R., Smith, S. A., Olivarez, N. P., Messer, W. B., Huynh, J. P., Wahala, W. M. P. B., White, L. J., Diamond, M. S., Baric, R. S., Crowe, J. E. & De Silva, A. M., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7439-7444 6 p.

Research output: Contribution to journalArticle

250 Scopus citations

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., You-Ten, A., Li, W. Y., Schalm, S., Su, S. M., Virtanen, C., Reifenberger, G., Ohashi, P. S., Barber, D. L., Figueroa, M. E., Melnick, A. & 2 others, Zúñiga-Pflücker, J. C. & Mak, T. W., Aug 30 2012, In : Nature. 488, 7413, p. 656-659 4 p.

Research output: Contribution to journalArticle

322 Scopus citations

Modeling Dynamic Regulatory Processes in Stroke

McDermott, J. E., Jarman, K., Taylor, R., Lancaster, M., Shankaran, H., Vartanian, K. B., Stevens, S. L., Stenzel-Poore, M. P. & Sanfilippo, A., Oct 1 2012, In : PLoS computational biology. 8, 10, e1002722.

Research output: Contribution to journalArticle

1 Scopus citations

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Juang, Y. C., Landry, M. C., Sanches, M., Vittal, V., Leung, C. C. Y., Ceccarelli, D. F., Mateo, A. R. F., Pruneda, J. N., Mao, D. Y. L., Szilard, R. K., Orlicky, S., Munro, M., Brzovic, P. S., Klevit, R. E., Sicheri, F. & Durocher, D., Feb 10 2012, In : Molecular Cell. 45, 3, p. 384-397 14 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

PDGF Receptor-α Does Not Promote HCMV Entry into Epithelial and Endothelial Cells but Increased Quantities Stimulate Entry by an Abnormal Pathway

Vanarsdall, A. L., Wisner, T. W., Lei, H., Kazlauskas, A. & Johnson, D. C., Sep 1 2012, In : PLoS pathogens. 8, 9, e1002905.

Research output: Contribution to journalArticle

55 Scopus citations

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

Berry, D., Schwab, C., Milinovich, G., Reichert, J., Ben Mahfoudh, K., Decker, T., Engel, M., Hai, B., Hainzl, E., Heider, S., Kenner, L., Müller, M., Rauch, I., Strobl, B., Wagner, M., Schleper, C., Urich, T. & Loy, A., Nov 1 2012, In : ISME Journal. 6, 11, p. 2091-2106 16 p.

Research output: Contribution to journalArticle

Open Access
140 Scopus citations

Poly-ICLC preconditioning protects the blood-brain barrier against ischemic injury in vitro through type i interferon signaling

Gesuete, R., Packard, A. E. B., Vartanian, K. B., Conrad, V. K., Stevens, S. L., Bahjat, F. R., Yang, T. & Stenzel-Poore, M. P., Nov 1 2012, In : Journal of Neurochemistry. 123, SUPPL. 2, p. 75-85 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury

Packard, A. E. B., Hedges, J. C., Bahjat, F. R., Stevens, S. L., Conlin, M. J., Salazar, A. M. & Stenzel-Poore, M. P., Feb 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 2, p. 242-247 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4 +8 - thymocytes and invariant NKT cells but not in Treg cells

Koguchi, Y., Buenafe, A. C., Thauland, T. J., Gardell, J. L., Bivins-Smith, E. R., Jacoby, D. B., Slifka, M. K. & Parker, D. C., Feb 21 2012, In : PloS one. 7, 2, e31296.

Research output: Contribution to journalArticle

24 Scopus citations
18 Scopus citations

Sontochin as a guide to the development of drugs against chloroquine-resistant malaria

Pou, S., Winter, R. W., Nilsen, A., Kelly, J. X., Li, Y., Doggett, J. S., Riscoe, E. W., Wegmann, K. W., Hinrichs, D. J. & Riscoe, M. K., Jul 1 2012, In : Antimicrobial agents and chemotherapy. 56, 7, p. 3475-3480 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural and functional characterization of mycobactericidal ubiquitin-derived peptides in model and bacterial membranes

Foss, M. H., Powers, K. M. & Purdy, G. E., Dec 11 2012, In : Biochemistry. 51, 49, p. 9922-9929 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
7 Scopus citations

Structural insights into the conformation and oligomerization of e2∼ubiquitin conjugates

Page, R. C., Pruneda, J. N., Amick, J., Klevit, R. E. & Misra, S., May 22 2012, In : Biochemistry. 51, 20, p. 4175-4187 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

Pruneda, J. N., Littlefield, P. J., Soss, S. E., Nordquist, K. A., Chazin, W. J., Brzovic, P. S. & Klevit, R. E., Sep 28 2012, In : Molecular Cell. 47, 6, p. 933-942 10 p.

Research output: Contribution to journalArticle

Open Access
171 Scopus citations

Sultam thioureas: Synthesis and antiviral activity against west nile virus

Feeny, R. M., Le, D. N., Parks, J. W., Epstein, M. G., Pagano, J. V., Abbene, A. C., Graham, E. B., Farrell, J. R., McGuire, J. R., Zoellner, R. W., Valente, E. J., Barklis, E. & Wood, W. J. L., Jan 1 2012, In : Synlett. 2, p. 301-305 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

Arpaia, E., Blaser, H., Quintela-Fandino, M., Duncan, G., Leong, H. S., Ablack, A., Nambiar, S. C., Lind, E. F., Silvester, J., Fleming, C. K., Rufini, A., Tusche, M. W., Brüstle, A., Ohashi, P. S., Lewis, J. D. & Mak, T. W., Feb 16 2012, In : Oncogene. 31, 7, p. 884-896 13 p.

Research output: Contribution to journalArticle

78 Scopus citations