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2015

Confinement-induced drug-tolerance in mycobacteria mediated by an efflux mechanism

Luthuli, B. B., Purdy, G. E. & Balagaddé, F. K., Aug 21 2015, In : PloS one. 10, 8, e0136231.

Research output: Contribution to journalArticle

5 Scopus citations

CpG preconditioning regulates miRNA expression that modulates genomic reprogramming associated with neuroprotection against ischemic injury

Vartanian, K. B., Mitchell, H. D., Stevens, S. L., Conrad, V. K., McDermott, J. E. & Stenzel-Poore, M. P., Feb 2 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 2, p. 257-266 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302

Chou, T. H., Delmar, J. A., Wright, C. C., Kumar, N., Radhakrishnan, A., Doh, J. K., Licon, M. H., Bolla, J. R., Lei, H. T., Rajashankar, K. R., Su, C. C., Purdy, G. E. & Yu, E. W., Dec 1 2015, In : Protein Science. 24, 12, p. 1942-1955 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cytokine-mediated activation of NK cells during viral infection

Freeman, B. E., Raué, H. P., Hill, A. B. & Slifka, M. K., 2015, In : Journal of virology. 89, 15, p. 7922-7931 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans

Tafesse, F. G., Rashidfarrokhi, A., Schmidt, F. I., Freinkman, E., Dougan, S., Dougan, M., Esteban, A., Maruyama, T., Strijbis, K. & Ploegh, H. L., 2015, In : PLoS pathogens. 11, 10, e1005188.

Research output: Contribution to journalArticle

22 Scopus citations

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria

Miley, G. P., Pou, S., Winter, R., Nilsen, A., Li, Y., Kelly, J. X., Stickles, A. M., Mather, M. W., Forquer, I. P., Pershing, A. M., White, K., Shackleford, D., Saunders, J., Chen, G., Ting, L. M., Kim, K., Zakharov, L. N., Donini, C., Burrows, J. N., Vaidya, A. B. & 2 others, Charman, S. A. & Riscoe, M. K., Sep 1 2015, In : Antimicrobial agents and chemotherapy. 59, 9, p. 5555-5560 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

GDF10 is a signal for axonal sprouting and functional recovery after stroke

Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., Bahjat, F. R., Stenzel-Poore, M. P., Kawaguchi, R., Coppola, G. & Carmichael, S. T., Nov 25 2015, In : Nature Neuroscience. 18, 12, p. 1737-1745 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

Genetic screen reveals link between the maternal effect sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in caenorhabditis elegans

Wu, Q., Cao, X., Yan, D., Wang, D. & Aballay, A., Dec 4 2015, In : Journal of Biological Chemistry. 290, 49, p. 29231-29239 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Global analysis of salmonella alternative sigma factor e on protein translation

Li, J., Nakayasu, E. S., Overall, C. C., Johnson, R. C., Kidwai, A. S., McDermott, J. E., Ansong, C., Heffron, F., Cambronne, E. D. & Adkins, J. N., Apr 3 2015, In : Journal of Proteome Research. 14, 4, p. 1716-1726 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

Earley, L. F., Kawano, Y., Adachi, K., Sun, X. X., Dai, M. S. & Nakai, H., 2015, In : Journal of virology. 89, 6, p. 3038-3048 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of salmonella typhimurium deubiquitinase ssel substrates by immunoaffinity enrichment and quantitative proteomic analysis

Nakayasu, E. S., Sydor, M. A., Brown, R. N., Sontag, R. L., Sobreira, T. J. P., Slysz, G. W., Humphrys, D. R., Skarina, T., Onoprienko, O., Di Leo, R., Deatherage Kaiser, B. L., Li, J., Ansong, C., Cambronne, E. D., Smith, R. D., Savchenko, A. & Adkins, J. N., Sep 4 2015, In : Journal of Proteome Research. 14, 9, p. 4029-4038 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds

Ortiz, D., Guiguemde, W. A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R. K. & Landfear, S. M., Apr 20 2015, In : PloS one. 10, 4, e0123598.

Research output: Contribution to journalArticle

18 Scopus citations

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP +/NADPH ratio

Itsumi, M., Inoue, S., Elia, A. J., Murakami, K., Sasaki, M., Lind, E. F., Brenner, D., Harris, I. S., Chio, I. I. C., Afzal, S., Cairns, R. A., Cescon, D. W., Elford, A. R., Ye, J., Lang, P. A., Li, W. Y., Wakeham, A., Duncan, G. S., Haight, J., You-Ten, A. & 4 others, Snow, B., Yamamoto, K., Ohashi, P. S. & Mak, T. W., Nov 1 2015, In : Cell Death and Differentiation. 22, 11, p. 1837-1848 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy

Stickles, A. M., Ting, L. M., Morrisey, J. M., Li, Y., Mather, M. W., Meermeier, E., Pershing, A. M., Forquer, I. P., Miley, G. P., Pou, S., Winter, R. W., Hinrichs, D. J., Kelly, J. X., Kim, K., Vaidya, A. B., Riscoe, M. K. & Nilsen, A., Jun 1 2015, In : American Journal of Tropical Medicine and Hygiene. 92, 6, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity

Nice, T. J., Baldridge, M. T., McCune, B. T., Norman, J. M., Lazear, H. M., Artyomov, M., Diamond, M. S. & Virgin, H. W., Jan 16 2015, In : Science. 347, 6219, p. 269-273 5 p.

Research output: Contribution to journalArticle

185 Scopus citations

Intestinal epithelial cell tyrosine kinase 2 transduces IL-22 signals to protect from acute colitis

Hainzl, E., Stockinger, S., Rauch, I., Heider, S., Berry, D., Lassnig, C., Schwab, C., Rosebrock, F., Milinovich, G., Schlederer, M., Wagner, M., Schleper, C., Loy, A., Urich, T., Kenner, L., Han, X., Decker, T., Strobl, B. & Müller, M., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 5011-5024 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Intestinal microbiota signatures associated with inflammation history in mice experiencing recurring colitis

Berry, D., Kuzyk, O., Rauch, I., Heider, S., Schwab, C., Hainzl, E., Decker, T., Müller, M., Strobl, B., Schleper, C., Urich, T., Wagner, M., Kenner, L. & Loy, A., 2015, In : Frontiers in Microbiology. 6, DEC, 01408.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Kharon1 null mutants of leishmania Mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages

Tran, K. D., Vieira, D. P., Sanchez, M. A., Valli, J., Gluenz, E. & Landfear, S. M., Aug 12 2015, In : PloS one. 10, 8, e0134432.

Research output: Contribution to journalArticle

7 Scopus citations

MiR-155 upregulation in dendritic cells is sufficient to break tolerance in vivo by negatively regulating SHIP1

Lind, E. F., Millar, D. G., Dissanayake, D., Savage, J. C., Grimshaw, N. K., Kerr, W. G. & Ohashi, P. S., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Noncanonical effects of IRF9 in intestinal inflammation: More than type I and type III interferons

Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Kenner, L., Müller, M. & Decker, T., 2015, In : Molecular and cellular biology. 35, 13, p. 2332-2343 12 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: A potential glucose sensor

Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P. A., Kamhawi, S. & Landfear, S. M., Jan 1 2015, In : FASEB Journal. 29, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Serum immunoregulatory proteins as predictors of overall survival of metastatic melanoma patients treated with ipilimumab

Koguchi, Y., Hoen, H. M., Bambina, S. A., Rynning, M. D., Fuerstenberg, R. K., Curti, B. D., Urba, W. J., Milburn, C., Bahjat, F. R., Korman, A. J. & Bahjat, K. S., Dec 1 2015, In : Cancer Research. 75, 23, p. 5084-5092 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural basis for the regulation of the MmpL transporters of Mycobacterium tuberculosis

Delmar, J. A., Chou, T. H., Wright, C. C., Licon, M. H., Doh, J. K., Radhakrishnan, A., Kumar, N., Lei, H. T., Bolla, J. R., Rajashankar, K. R., Su, C. C., Purdy, G. E. & Yu, E. W., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28559-28574 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of plasmodium falciparum

Stickles, A. M., De Almeida, M. J., Morrisey, J. M., Sheridan, K. A., Forquer, I. P., Nilsen, A., Winter, R. W., Burrows, J. N., Fidock, D. A., Vaidya, A. B. & Riscoe, M. K., Apr 1 2015, In : Antimicrobial agents and chemotherapy. 59, 4, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells

Berry, D., Mader, E., Lee, T. K., Woebken, D., Wang, Y., Zhu, D., Palatinszky, M., Schintlmeister, A., Schmid, M. C., Hanson, B. T., Shterzer, N., Mizrahi, I., Rauch, I., Decker, T., Bocklitz, T., Popp, J., Gibson, C. M., Fowler, P. W., Huang, W. E. & Wagner, M., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. E194-E203

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

Type i interferons link viral infection to enhanced epithelial turnover and repair

Sun, L., Miyoshi, H., Origanti, S., Nice, T. J., Barger, A. C., Manieri, N. A., Fogel, L. A., French, A. R., Piwnica-Worms, D., Piwnica-Worms, H., Virgin, H. W., Lenschow, D. J. & Stappenbeck, T. S., Jan 14 2015, In : Cell Host and Microbe. 17, 1, p. 85-97 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

Wauer, T., Swatek, K. N., Wagstaff, J. L., Gladkova, C., Pruneda, J. N., Michel, M. A., Gersch, M., Johnson, C. M., Freund, S. M. V. & Komander, D., Feb 3 2015, In : EMBO Journal. 34, 3, p. 307-325 19 p.

Research output: Contribution to journalArticle

Open Access
147 Scopus citations
2014

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

DaRosa, P. A., Wang, Z., Jiang, X., Pruneda, J. N., Cong, F., Klevit, R. E. & Xu, W., Oct 19 2014, In : Nature. 517, 7533

Research output: Contribution to journalArticle

91 Scopus citations

CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation

Thauland, T. J., Koguchi, Y., Dustin, M. L. & Parker, D. C., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 5894-5903 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis

Radhakrishnan, A., Kumar, N., Wright, C. C., Chou, T. H., Tringides, M. L., Bolla, J. R., Lei, H. T., Rajashankar, K. R., Su, C. C., Purdy, G. E. & Yu, E. W., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 16526-16540 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis

Kumar, N., Radhakrishnan, A., Wright, C. C., Chou, T. H., Lei, H. T., Bolla, J. R., Tringides, M. L., Rajashankar, K. R., Su, C. C., Purdy, G. E. & Yu, E. W., Apr 2014, In : Protein Science. 23, 4, p. 423-432 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

Messer, W. B., De Alwis, R., Yount, B. L., Royal, S. R., Huynh, J. P., Smith, S. A., Crowe, J. E., Doranz, B. J., Kahle, K. M., Pfaff, J. M., White, L. J., Sariol, C. A., De Silva, A. M. & Baric, R. S., Feb 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 5, p. 1939-1944 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Nilsen, A., Miley, G. P., Forquer, I. P., Mather, M. W., Katneni, K., Li, Y., Pou, S., Pershing, A. M., Stickles, A. M., Ryan, E., Kelly, J. X., Doggett, J. S., White, K. L., Hinrichs, D. J., Winter, R. W., Charman, S. A., Zakharov, L. N., Bathurst, I., Burrows, J. N., Vaidya, A. B. & 1 others, Riscoe, M. K., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3818-3834 17 p.

Research output: Contribution to journalArticle

70 Scopus citations

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Adachi, K., Enoki, T., Kawano, Y., Veraz, M. & Nakai, H., Jan 17 2014, In : Nature communications. 5, 3075.

Research output: Contribution to journalArticle

50 Scopus citations

E2∼Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis

Pruneda, J. N., Smith, F. D., Daurie, A., Swaney, D. L., Villén, J., Scott, J. D., Stadnyk, A. W., Le Trong, I., Stenkamp, R. E., Klevit, R. E., Rohde, J. R. & Brzovic, P. S., Mar 3 2014, In : EMBO Journal. 33, 5, p. 437-449 13 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Freeze-thaw stress of Alhydrogel® alone is sufficient to reduce the immunogenicity of a recombinant hepatitis B vaccine containing native antigen

Clapp, T., Munks, M. W., Trivedi, R., Kompella, U. B. & Braun, L. T. J., Jan 1 2014, In : Vaccine. 32, 30, p. 3765-3771 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin a, localizes to the Golgi and is cleaved by furin

Tafesse, F. G., Guimaraes, C. P., Maruyama, T., Carette, J. E., Lory, S., Brummelkamp, T. R. & Ploegh, H. L., 2014, In : Journal of Biological Chemistry. 289, 35, p. 24005-24018 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells

Howard, P. W., Wright, C. C., Howard, T. & Johnson, D. C., 2014, In : Journal of virology. 88, 19, p. 11178-11186 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats

Lin, P., Bach, M., Asquith, M., Lee, A. Y., Akileswaran, L., Stauffer, P., Davin, S., Pan, Y., Cambronne, E. D., Dorris, M., Debelius, J. W., Lauber, C. L., Ackermann, G., Baeza, Y. V., Gill, T., Knight, R., Colbert, R. A., Taurog, J. D., Van Gelder, R. N. & Rosenbaum, J. T., Aug 20 2014, In : PloS one. 9, 8, e105684.

Research output: Contribution to journalArticle

140 Scopus citations

Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III

Corrales-Aguilar, E., Trilling, M., Hunold, K., Fiedler, M., Le, V. T. K., Reinhard, H., Ehrhardt, K., Mercé-Maldonado, E., Aliyev, E., Zimmermann, A., Johnson, D. C. & Hengel, H., May 2014, In : PLoS pathogens. 10, 5, e1004131.

Research output: Contribution to journalArticle

39 Scopus citations

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S. M., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking

Nolz, J. C. & Harty, J. T., Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1013-1026 14 p.

Research output: Contribution to journalArticle

54 Scopus citations

Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

Schwab, C., Berry, D., Rauch, I., Rennisch, I., Ramesmayer, J., Hainzl, E., Heider, S., Decker, T., Kenner, L., Müller, M., Strobl, B., Wagner, M., Schleper, C., Loy, A. & Urich, T., May 2014, In : ISME Journal. 8, 5, p. 1101-1114 14 p.

Research output: Contribution to journalArticle

Open Access
91 Scopus citations

Matrix effects in biological mass spectrometry imaging: Identification and compensation

Lanekoff, I., Stevens, S. L., Stenzel-Poore, M. P. & Laskin, J., Jun 16 2014, In : Analyst. 139, 14, p. 3528-3532 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

Janowsky, A., Eshleman, A. J., Johnson, R. A., Wolfrum, K. M., Hinrichs, D. J., Yang, J., Zabriskie, T. M., Smilkstein, M. J. & Riscoe, M. K., Jul 2014, In : Psychopharmacology. 231, 14, p. 2771-2783 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Murine norovirus protein NS1/2 aspartate to glutamate mutation, sufficient for persistence, reorients side chain of surface exposed tryptophan within a novel structured domain

Borin, B. N., Tang, W., Nice, T. J., Mccune, B. T., Virgin, H. W. & Krezel, A. M., Jul 2014, In : Proteins: Structure, Function and Bioinformatics. 82, 7, p. 1200-1209 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

NtrBC and Nac contribute to efficient shigella flexneri intracellular replication

Waddell, C. D., Walter, T. J., Pacheco, S. A., Purdy, G. E. & Runyen-Janecky, L. J., Jul 2014, In : Journal of bacteriology. 196, 14, p. 2578-2586 9 p.

Research output: Contribution to journalArticle

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

Maric, M., Haugo, A. C., Dauer, W., Johnson, D. & Roller, R. J., Jul 2014, In : Virology. 460-461, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2

Head, B. & Aballay, A., Oct 1 2014, In : PLoS genetics. 10, 10

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of NO synthesis, local inflammation, and innate: Immunity to pathogens by BET family proteins

Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, A. M., Bradner, J., Muhar, M., Zuber, J., Müller, M. & Decker, T., Feb 2014, In : Molecular and cellular biology. 34, 3, p. 415-427 13 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations