Research Output 1969 2019

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2016
5 Citations (Scopus)

Rise and fall of vector infectivity during sequential strain displacements by mosquito-borne dengue virus

Andrade, C. C., Young, K. I., Johnson, W. L., Villa, M. E., Buraczyk, C. A., Messer, W. & Hanley, K. A., Nov 1 2016, In : Journal of Evolutionary Biology. 29, 11, p. 2205-2218 14 p.

Research output: Contribution to journalArticle

dengue fever
Dengue virus
infectivity
mosquito
Culicidae
1 Citation (Scopus)

Strength in Numbers: Visualizing CTL-Mediated Killing In Vivo

Nolz, J. & Hill, A., Feb 16 2016, In : Immunity. 44, 2, p. 207-208 2 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Cytotoxic T-Lymphocytes
5 Citations (Scopus)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases

Kol, M., Panatala, R., Nordmann, M., Swart, L., Van Suijlekom, L., Cabukusta, B., Hilderink, A., Grabietz, T., Mina, J. G. M., Somerharju, P., Korneev, S., Tafesse, F. & Holthuis, J. C. M., Jul 1 2016, In : Journal of Lipid Research. 57, 7, p. 1273-1285 13 p.

Research output: Contribution to journalArticle

Sphingolipids
Biosynthesis
Catalytic Domain
Enzymes
Cell membranes
12 Citations (Scopus)

Targeting the cytochrome bc1 complex of Leishmania parasites for discovery of novel drugs

Ortiz, D., Forquer, I., Boitz, J., Soysa, R., Elya, C., Fulwiler, A., Nilsen, A., Polley, T., Riscoe, M., Ullman, B. & Landfear, S., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4972-4982 11 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Leishmania
Quinolones
Drug Discovery
Parasites
5 Citations (Scopus)

Trimer enhancement mutation effects on HIV-1 matrix protein binding activities

Alfadhli, A., Mack, A., Ritchie, C., Cylinder, I., Harper, L., Tedbury, P. R., Freed, E. O. & Barklis, E., Jun 1 2016, In : Journal of Virology. 90, 12, p. 5657-5664 8 p.

Research output: Contribution to journalArticle

protein binding
Human immunodeficiency virus 1
Protein Binding
HIV-1
mutation
23 Citations (Scopus)

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

Nice, T., Osborne, L. C., Tomov, V. T., Artis, D., Wherry, E. J. & Virgin, H. W., Jun 1 2016, In : PLoS Pathogens. 12, 6, e1005684.

Research output: Contribution to journalArticle

Interferon alpha-beta Receptor
Norovirus
Adaptive Immunity
Dendritic Cells
Interferon Type I
2015
21 Citations (Scopus)

Analysis of HIV-1 gag protein interactions via biotin ligase tagging

Ritchie, C., Cylinder, I., Platt, E. J. & Barklis, E., 2015, In : Journal of Virology. 89, 7, p. 3988-4001 14 p.

Research output: Contribution to journalArticle

gag Gene Products
biotin
Ligases
Biotin
Human immunodeficiency virus 1
10 Citations (Scopus)

Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression

Li, J., Overall, C. C., Nakayasu, E. S., Kidwai, A. S., Jones, M. B., Johnson, R. C., Nguyen, N. T., McDermott, J. E., Ansong, C., Heffron, F., Cambronne, E. & Adkins, J. N., 2015, In : Frontiers in Microbiology. 6, FEB

Research output: Contribution to journalArticle

Islands
Salmonella
Gene Expression
Infection
Genes
1 Citation (Scopus)
Ultraviolet Rays
Calibration
Practice Guidelines
Decontamination
Disinfection
27 Citations (Scopus)

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

Sali, T. M., Pryke, K. M., Abraham, J., Liu, A., Archer, I., Broeckel, R., Staverosky, J., Smith, J. L., Al-Shammari, A., Amsler, L., Sheridan, K., Nilsen, A., Streblow, D. & De Filippis, V., 2015, In : PLoS Pathogens. 11, 12, e1005324.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-3
Alphavirus
Antiviral Agents
Interferon Type I
Interferons
12 Citations (Scopus)

ChIP-seq analysis of the σe regulon of salmonella enterica serovar typhimurium reveals new genes implicated in heat shock and oxidative stress response

Li, J., Overall, C. C., Johnson, R. C., Jones, M. B., McDermott, J. E., Heffron, F., Adkins, J. N. & Cambronne, E., Sep 21 2015, In : PLoS One. 10, 9, e0138466.

Research output: Contribution to journalArticle

Regulon
regulon
Salmonella
Oxidative stress
Salmonella enterica
5 Citations (Scopus)

Confinement-induced drug-tolerance in mycobacteria mediated by an efflux mechanism

Luthuli, B. B., Purdy, G. & Balagaddé, F. K., Aug 21 2015, In : PLoS One. 10, 8, e0136231.

Research output: Contribution to journalArticle

Drug Tolerance
Mycobacterium
drug resistance
Macrophages
macrophages
9 Citations (Scopus)

CpG preconditioning regulates miRNA expression that modulates genomic reprogramming associated with neuroprotection against ischemic injury

Vartanian, K. B., Mitchell, H. D., Stevens, S. L., Conrad, V. K., McDermott, J. E. & Stenzel-Poore, M., Feb 2 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 2, p. 257-266 10 p.

Research output: Contribution to journalArticle

Cytosine
Guanine
MicroRNAs
Phosphates
Wounds and Injuries
4 Citations (Scopus)

Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302

Chou, T. H., Delmar, J. A., Wright, C. C., Kumar, N., Radhakrishnan, A., Doh, J. K., Licon, M. H., Bolla, J. R., Lei, H. T., Rajashankar, K. R., Su, C. C., Purdy, G. & Yu, E. W., Dec 1 2015, In : Protein Science. 24, 12, p. 1942-1955 14 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Cell Wall
Crystal structure
Cells
Membrane Proteins
15 Citations (Scopus)

Cytokine-mediated activation of NK cells during viral infection

Freeman, B. E., Raué, H. P., Hill, A. & Slifka, M., 2015, In : Journal of Virology. 89, 15, p. 7922-7931 10 p.

Research output: Contribution to journalArticle

natural killer cells
Virus Diseases
Natural Killer Cells
cytokines
Cytokines
24 Citations (Scopus)

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria

Miley, G. P., Pou, S., Winter, R., Nilsen, A., Li, Y., Kelly, J. X., Stickles, A. M., Mather, M. W., Forquer, I. P., Pershing, A. M., White, K., Shackleford, D., Saunders, J., Chen, G., Ting, L. M., Kim, K., Zakharov, L. N., Donini, C., Burrows, J. N., Vaidya, A. B. & 2 others, Charman, S. A. & Riscoe, M., Sep 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5555-5560 6 p.

Research output: Contribution to journalArticle

Prodrugs
Malaria
Safety
Zygote
Carbonates
10 Citations (Scopus)

Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates

McBurney, S. P., Sunshine, J. E., Gabriel, S., Huynh, J. P., Sutton, W. F., Fuller, D. H., Haigwood, N. & Messer, W., Nov 28 2015, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

scaffolding proteins
Dengue virus
Dengue Virus
DNA Vaccines
Macaca
4 Citations (Scopus)

Flagellar membrane proteins in kinetoplastid parasites

Landfear, S., Tran, K. D. & Sanchez, M., Sep 1 2015, In : IUBMB Life. 67, 9, p. 668-676 9 p.

Research output: Contribution to journalArticle

Membrane Proteins
Parasites
Flagella
Membranes
Protozoa
55 Citations (Scopus)

GDF10 is a signal for axonal sprouting and functional recovery after stroke

Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., Bahjat, F., Stenzel-Poore, M., Kawaguchi, R., Coppola, G. & Carmichael, S. T., Nov 25 2015, In : Nature Neuroscience. 18, 12, p. 1737-1745 9 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 10
Stroke
Neurons
RNA Sequence Analysis
Genome-Wide Association Study
6 Citations (Scopus)

Global analysis of salmonella alternative sigma factor e on protein translation

Li, J., Nakayasu, E. S., Overall, C. C., Johnson, R. C., Kidwai, A. S., McDermott, J. E., Ansong, C., Heffron, F., Cambronne, E. & Adkins, J. N., Apr 3 2015, In : Journal of Proteome Research. 14, 4, p. 1716-1726 11 p.

Research output: Contribution to journalArticle

Sigma Factor
Salmonella
Protein Biosynthesis
Proteomics
Proteome
17 Citations (Scopus)

Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein

Earley, L. F., Kawano, Y., Adachi, K., Sun, X-X., Dai, M. & Nakai, H., 2015, In : Journal of Virology. 89, 6, p. 3038-3048 11 p.

Research output: Contribution to journalArticle

Dependovirus
Nuclear Localization Signals
serotypes
capsid
Capsid
6 Citations (Scopus)

Identification of salmonella typhimurium deubiquitinase ssel substrates by immunoaffinity enrichment and quantitative proteomic analysis

Nakayasu, E. S., Sydor, M. A., Brown, R. N., Sontag, R. L., Sobreira, T. J. P., Slysz, G. W., Humphrys, D. R., Skarina, T., Onoprienko, O., Di Leo, R., Deatherage Kaiser, B. L., Li, J., Ansong, C., Cambronne, E., Smith, R. D., Savchenko, A. & Adkins, J. N., Sep 4 2015, In : Journal of Proteome Research. 14, 9, p. 4029-4038 10 p.

Research output: Contribution to journalArticle

Salmonella
Salmonella typhimurium
Proteomics
Substrates
Ubiquitin
13 Citations (Scopus)

Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds

Ortiz, D., Guiguemde, W. A., Johnson, A., Elya, C., Anderson, J., Clark, J., Connelly, M., Yang, L., Min, J., Sato, Y., Guy, R. K. & Landfear, S., Apr 20 2015, In : PLoS One. 10, 4, e0123598.

Research output: Contribution to journalArticle

Monosaccharide Transport Proteins
antimalarials
Antimalarials
Plasmodium falciparum
hexoses
18 Citations (Scopus)

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy

Stickles, A. M., Ting, L. M., Morrisey, J. M., Li, Y., Mather, M. W., Meermeier, E., Pershing, A. M., Forquer, I. P., Miley, G. P., Pou, S., Winter, R. W., Hinrichs, D. J., Kelly, J. X., Kim, K., Vaidya, A. B., Riscoe, M. & Nilsen, A., Jun 1 2015, In : American Journal of Tropical Medicine and Hygiene. 92, 6, p. 1195-1201 7 p.

Research output: Contribution to journalArticle

Electron Transport Complex III
Antimalarials
Malaria
Parasites
Atovaquone
149 Citations (Scopus)

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

Lazear, H., Nice, T. & Diamond, M., Jul 21 2015, In : Immunity. 43, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

Interferons
Interferon-gamma
Antiviral Agents
Virus Diseases
Interferon Type I
6 Citations (Scopus)

Kharon1 null mutants of leishmania Mexicana are avirulent in mice and exhibit a cytokinesis defect within macrophages

Tran, K. D., Vieira, D. P., Sanchez, M., Valli, J., Gluenz, E. & Landfear, S., Aug 12 2015, In : PLoS One. 10, 8, e0134432.

Research output: Contribution to journalArticle

Leishmania mexicana
amastigotes
Cytokinesis
Macrophages
cytokinesis
22 Citations (Scopus)

MiR-155 upregulation in dendritic cells is sufficient to break tolerance in vivo by negatively regulating SHIP1

Lind, E., Millar, D. G., Dissanayake, D., Savage, J. C., Grimshaw, N. K., Kerr, W. G. & Ohashi, P. S., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4632-4640 9 p.

Research output: Contribution to journalArticle

Dendritic Cells
Up-Regulation
T-Lymphocytes
Autoimmunity
Cytokines
18 Citations (Scopus)

Molecular mechanisms of CD8+ T cell trafficking and localization

Nolz, J., Jul 8 2015, In : Cellular and Molecular Life Sciences. 72, 13, p. 2461-2473 13 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Infection
Aptitude
Chemokine Receptors
Foreign Bodies
15 Citations (Scopus)

Regulation and biological function of a flagellar glucose transporter in Leishmania mexicana: A potential glucose sensor

Rodriguez-Contreras, D., Aslan, H., Feng, X., Tran, K., Yates, P., Kamhawi, S. & Landfear, S., Jan 1 2015, In : FASEB Journal. 29, 1, p. 11-24 14 p.

Research output: Contribution to journalArticle

Glucose sensors
Facilitative Glucose Transport Proteins
Glucose
Parasites
Leishmania mexicana
11 Citations (Scopus)

Structural basis for the regulation of the MmpL transporters of Mycobacterium tuberculosis

Delmar, J. A., Chou, T. H., Wright, C. C., Licon, M. H., Doh, J. K., Radhakrishnan, A., Kumar, N., Lei, H. T., Bolla, J. R., Rajashankar, K. R., Su, C. C., Purdy, G. & Yu, E. W., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28559-28574 16 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Membrane Proteins
Fatty Acids
Cell Wall
Palmitic Acid
22 Citations (Scopus)

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of plasmodium falciparum

Stickles, A. M., De Almeida, M. J., Morrisey, J. M., Sheridan, K. A., Forquer, I. P., Nilsen, A., Winter, R. W., Burrows, J. N., Fidock, D. A., Vaidya, A. B. & Riscoe, M., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

Qi
Electron Transport Complex III
Quinolones
Plasmodium falciparum
Atovaquone
2014
12 Citations (Scopus)

CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation

Thauland, T. J., Koguchi, Y., Dustin, M. L. & Parker, D., Dec 15 2014, In : Journal of Immunology. 193, 12, p. 5894-5903 10 p.

Research output: Contribution to journalArticle

Immunological Synapses
Regulatory T-Lymphocytes
Dendritic Cells
Cell Movement
Lymphocyte Function-Associated Antigen-1
4 Citations (Scopus)

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis

Kumar, N., Radhakrishnan, A., Wright, C. C., Chou, T. H., Lei, H. T., Bolla, J. R., Tringides, M. L., Rajashankar, K. R., Su, C. C., Purdy, G. & Yu, E. W., 2014, In : Protein Science. 23, 4, p. 423-432 10 p.

Research output: Contribution to journalArticle

Drug Residues
Fluorescence Polarization
Poisons
Protein Subunits
Anti-Infective Agents
46 Citations (Scopus)

Dengue virus envelope protein domain I/II hinge determines long-lived serotype-specific dengue immunity

Messer, W., De Alwis, R., Yount, B. L., Royal, S. R., Huynh, J. P., Smith, S. A., Crowe, J. E., Doranz, B. J., Kahle, K. M., Pfaff, J. M., White, L. J., Sariol, C. A., De Silva, A. M. & Baric, R. S., Feb 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 5, p. 1939-1944 6 p.

Research output: Contribution to journalArticle

Viral Envelope Proteins
Dengue Virus
Dengue
Immunity
Severe Dengue
59 Citations (Scopus)

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Nilsen, A., Miley, G. P., Forquer, I. P., Mather, M. W., Katneni, K., Li, Y., Pou, S., Pershing, A. M., Stickles, A. M., Ryan, E., Kelly, J. X., Doggett, J., White, K. L., Hinrichs, D. J., Winter, R. W., Charman, S. A., Zakharov, L. N., Bathurst, I., Burrows, J. N., Vaidya, A. B. & 1 others, Riscoe, M., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3818-3834 17 p.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Atovaquone
4-Quinolones
Falciparum Malaria
38 Citations (Scopus)

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Adachi, K., Enoki, T., Kawano, Y., Veraz, M. & Nakai, H., Jan 17 2014, In : Nature Communications. 5, 3075.

Research output: Contribution to journalArticle

Drawing (graphics)
High-Throughput Nucleotide Sequencing
Dependovirus
sequencing
Capsid
10 Citations (Scopus)

Herpes simplex virus gE/gI extracellular domains promote axonal transport and spread from neurons to epithelial cells

Howard, P. W., Wright, C. C., Howard, T. & Johnson, D., 2014, In : Journal of Virology. 88, 19, p. 11178-11186 9 p.

Research output: Contribution to journalArticle

herpes simplex
Axonal Transport
Simplexvirus
epithelial cells
neurons
116 Citations (Scopus)

HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats

Lin, P., Bach, M., Asquith, M., Lee, A. Y., Akileswaran, L., Stauffer, P., Davin, S., Pan, Y., Cambronne, E., Dorris, M., Debelius, J. W., Lauber, C. L., Ackermann, G., Baeza, Y. V., Gill, T., Knight, R., Colbert, R. A., Taurog, J. D., Van Gelder, R. N. & Rosenbaum, J. J., Aug 20 2014, In : PLoS One. 9, 8, e105684.

Research output: Contribution to journalArticle

Transgenic Rats
HLA-B27 Antigen
intestinal microorganisms
Rats
genetically modified organisms
35 Citations (Scopus)

Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III

Corrales-Aguilar, E., Trilling, M., Hunold, K., Fiedler, M., Le, V. T. K., Reinhard, H., Ehrhardt, K., Mercé-Maldonado, E., Aliyev, E., Zimmermann, A., Johnson, D. & Hengel, H., 2014, In : PLoS Pathogens. 10, 5, e1004131.

Research output: Contribution to journalArticle

Fc Receptors
Cytomegalovirus
Carrier Proteins
Immunoglobulin G
Antigen-Antibody Complex
20 Citations (Scopus)

Identification of the intracellular gate for a member of the equilibrative nucleoside transporter (ENT) family

Valdés, R., Elferich, J., Shinde, U. & Landfear, S., Mar 30 2014, In : Journal of Biological Chemistry. 289, 13, p. 8799-8809 11 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Leishmania donovani
Conformations
Crystal structure
Physiological Phenomena
40 Citations (Scopus)

Matrix effects in biological mass spectrometry imaging: Identification and compensation

Lanekoff, I., Stevens, S. L., Stenzel-Poore, M. & Laskin, J., Jul 21 2014, In : Analyst. 139, 14, p. 3528-3532 5 p.

Research output: Contribution to journalArticle

Mass spectrometry
Middle Cerebral Artery Infarction
Mass Spectrometry
mass spectrometry
Phosphatidylcholines

NtrBC and Nac contribute to efficient shigella flexneri intracellular replication

Waddell, C. D., Walter, T. J., Pacheco, S. A., Purdy, G. & Runyen-Janecky, L. J., 2014, In : Journal of Bacteriology. 196, 14, p. 2578-2586 9 p.

Research output: Contribution to journalArticle

Shigella flexneri
Shigella
Microarray Analysis
Cultured Cells
Epithelial Cells
11 Citations (Scopus)

Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

Maric, M., Haugo, A. C., Dauer, W., Johnson, D. & Roller, R. J., 2014, In : Virology. 460-461, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Viral Fusion Proteins
Nuclear Envelope
Human Herpesvirus 1
Nuclear Lamina
Virus Diseases
18 Citations (Scopus)

Reprogramming the response to stroke by preconditioning

Stevens, S. L., Vartanian, K. B. & Stenzel-Poore, M., 2014, In : Stroke. 45, 8, p. 2527-2531 5 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Brain Ischemia
Stroke
Brain
5 Citations (Scopus)

RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release

Lopez, C., Sloan, R., Cylinder, I., Kozak, S. L., Kabat, D. & Barklis, E., 2014, In : Virology. 462-463, 1, p. 126-134 9 p.

Research output: Contribution to journalArticle

env Genes
gag Gene Products
HIV-1
RNA
Messenger RNA
16 Citations (Scopus)

The roles of lipids and nucleic acids in HIV-1 assembly

Alfadhli, A. & Barklis, E., 2014, In : Frontiers in Microbiology. 5, MAY

Research output: Contribution to journalArticle

gag Gene Products
Nucleic Acids
HIV-1
Lipids
Nucleocapsid
53 Citations (Scopus)

Toll-like receptors and ischemic brain injury

Gesuete, R., Kohama, S. & Stenzel-Poore, M., 2014, In : Journal of Neuropathology and Experimental Neurology. 73, 5, p. 378-386 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Brain Injuries
Stroke
Wounds and Injuries
Brain Ischemia
1 Citation (Scopus)

Transporters, channels and receptors in flagella

Rodriguez-Contreras, D. & Landfear, S., 2014, In : Channels (Austin, Tex.). 8, 6, p. 477-478 2 p.

Research output: Contribution to journalArticle

2013
21 Citations (Scopus)

A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory

Rowe, A. M., Murray, S., Raué, H. P., Koguchi, Y., Slifka, M. & Parker, D., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3663-3672 10 p.

Research output: Contribution to journalArticle

Phosphotransferases
T-Lymphocytes
Lymphocytic choriomeningitis virus
Bone Marrow
Viruses
13 Citations (Scopus)

Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site

Alfadhli, A., McNett, H., Eccles, J., Tsagli, S., Noviello, C., Sloan, R., Lopez, C., Peyton, D. H. & Barklis, E., Jan 4 2013, In : Journal of Biological Chemistry. 288, 1, p. 666-676 11 p.

Research output: Contribution to journalArticle

RNA
HIV-1
Binding Sites
Ligands
Proteins