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2018

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

Harriff, M. J., McMurtrey, C., Froyd, C. A., Jin, H., Cansler, M., Null, M., Worley, A., Meermeier, E. W., Swarbrick, G., Nilsen, A., Lewinsohn, D. A., Hildebrand, W., Adams, E. J. & Lewinsohn, D. M., Jan 1 2018, In : Science Immunology. 3, 25, eaao2556.

Research output: Contribution to journalArticle

17 Scopus citations

Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection

Olaitan, A. O. & Aballay, A., Sep 1 2018, In : PLoS Genetics. 14, 9, e1007693.

Research output: Contribution to journalArticle

Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells

Van Winkle, J. A., Robinson, B. A., Peters, A. M., Li, L., Nouboussi, R. V., Mack, M. & Nice, T., Nov 14 2018, In : Cell host & microbe. 24, 5, p. 665-676 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pervasive tertiary structure in the dengue virus RNA genome

Dethoff, E. A., Boerneke, M. A., Gokhale, N. S., Muhire, B. M., Martin, D. P., Sacco, M. T., McFadden, M. J., Weinstein, J. B., Messer, W., Horner, S. M. & Weeks, K. M., Nov 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. 11513-11518 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Statistical detection of differentially abundant ions in mass spectrometry-based imaging experiments with complex designs

Bemis, K. A., Guo, D., Harry, A. J., Thomas, M., Lanekoff, I., Stenzel-Poore, M., Stevens, S. L., Laskin, J. & Vitek, O., Jan 1 2018, (Accepted/In press) In : International Journal of Mass Spectrometry.

Research output: Contribution to journalArticle

1 Scopus citations

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

McConnell, E. V., Bruzual, I., Pou, S., Winter, R., Dodean, R. A., Smilkstein, M. J., Krollenbrock, A., Nilsen, A., Zakharov, L. N., Riscoe, M. & Doggett, J., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

7 Scopus citations

The human cytomegalovirus trimer and pentamer promote sequential steps in entry into epithelial and endothelial cells at cell surfaces and endosomes

Liu, J., Jardetzky, T. S., Chin, A. L., Johnson, D. & Vanarsdall, A., Nov 1 2018, In : Journal of Virology. 92, 21, e01336.

Research output: Contribution to journalArticle

9 Scopus citations

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation

Dimitriou, I. D., Lee, K., Akpan, I., Lind, E., Barr, V. A., Ohashi, P. S., Samelson, L. E. & Rottapel, R., Jul 31 2018, In : Cell Reports. 24, 5, p. 1123-1135 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch, A. J., Roberts, V. H. J., Grigsby, P. L., Haese, N., Schabel, M. C., Wang, X., Lo, J. O., Liu, Z., Kroenke, C. D., Smith, J. L., Kelleher, M., Broeckel, R., Kreklywich, C. N., Parkins, C. J., Denton, M., Smith, P., Defilippis, V., Messer, W., Nelson, J. A., Hennebold, J. D. & 12 others, Grafe, M., Colgin, L., Lewis, A., Ducore, R., Swanson, T., Legasse, A. W., Axthelm, M. K., MacAllister, R., Moses, A. V., Morgan, T. K., Frias, A. E. & Streblow, D. N., Dec 1 2018, In : Nature Communications. 9, 1, 263.

Research output: Contribution to journalArticle

50 Scopus citations
2017

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

Research output: Contribution to journalArticle

28 Scopus citations

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P. J. S., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1

Gladkova, C., Schubert, A. F., Wagstaff, J. L., Pruneda, J. N., Freund, S. M. V. & Komander, D., Dec 15 2017, In : EMBO Journal. 36, 24, p. 3555-3572 18 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

A novel agonist of the trif pathway induces a cellular state refractory to replication of Zika, Chikungunya, and dengue viruses

Pryke, K. M., Abraham, J., Sali, T. M., Gall, B. J., Archer, I., Liu, A., Bambina, S., Baird, J., Gough, M., Chakhtoura, M., Haddad, E. K., Kirby, I. T., Nilsen, A., Streblow, D. N., Hirsch, A. J., Smith, J. L. & Defilippis, V. R., May 1 2017, In : mBio. 8, 3, e00452-17.

Research output: Contribution to journalArticle

18 Scopus citations

Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes

Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P. A., Li, Y., Riscoe, M. K., Ullman, B. & Roberts, S. C., Jan 1 2017, In : Infection and Immunity. 85, 1, e00554-16.

Research output: Contribution to journalArticle

21 Scopus citations
4 Scopus citations

CD40L is transferred to antigen-presenting B cells during delivery of T-cell help

Gardell, J. L. & Parker, D., Jan 1 2017, In : European Journal of Immunology. 47, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death

Cabukusta, B., Nettebrock, N. T., Kol, M., Hilderink, A., Tafesse, F. G. & Holthuis, J. C. M., Aug 31 2017, In : Bioscience Reports. 37, 4, BSR20170867.

Research output: Contribution to journalArticle

3 Scopus citations

CMV immune evasion and manipulation of the immune system with aging

Jackson, S. E., Redeker, A., Arens, R., van Baarle, D., van Den Berg, S. P. H., Benedict, C. A., Čičin-Šain, L., Hill, A. & Wills, M. R., Jun 24 2017, (Accepted/In press) In : GeroScience. p. 1-19 19 p.

Research output: Contribution to journalArticle

28 Scopus citations

Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production

Polesso, F., Sarker, M., Anderson, A., Parker, D. & Murray, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14779.

Research output: Contribution to journalArticle

7 Scopus citations

Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells

Gardell, J. L. & Parker, D., Oct 1 2017, In : PLoS One. 12, 10, e0186573.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations

Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche

Tomov, V. T., Palko, O., Lau, C. W., Pattekar, A., Sun, Y., Tacheva, R., Bengsch, B., Manne, S., Cosma, G. L., Eisenlohr, L. C., Nice, T., Virgin, H. W. & Wherry, E. J., 2017, (Accepted/In press) In : Immunity.

Research output: Contribution to journalArticle

20 Scopus citations

Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation

Cao, X., Kajino-Sakamoto, R., Doss, A. & Aballay, A., Nov 7 2017, In : Cell Reports. 21, 6, p. 1442-1451 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells

Osborn, J. F., Mooster, J. L., Hobbs, S. J., Munks, M., Barry, C., Harty, J. T., Hill, A. & Nolz, J., Oct 13 2017, In : Science immunology. 2, 16

Research output: Contribution to journalArticle

14 Scopus citations

Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of interferon lambda against norovirus and reovirus

Baldridge, M. T., Lee, S., Brown, J. J., McAllister, N., Urbanek, K., Dermody, T. S., Nice, T. & Virgin, H. W., 2017, In : Journal of Virology. 91, 7, e02079-16.

Research output: Contribution to journalArticle

49 Scopus citations

Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans

Murray, S., Nesterenko, P. A., Vanarsdall, A., Munks, M., Smart, S. M., Veziroglu, E. M., Sagario, L. C., Lee, R., Claas, F. H. J., Doxiadis, I. I. N., McVoy, M. A., Adler, S. P. & Hill, A., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 1889-1899 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii

Alday, P. H., Bruzual, I., Nilsen, A., Pou, S., Winter, R., Mamoun, C. B., Riscoe, M. & Doggett, J., Feb 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 2, e01866.

Research output: Contribution to journalArticle

21 Scopus citations

Herpes simplex virus gE/gI and US9 promote both envelopment and sorting of virus particles in the cytoplasm of neurons, two processes that precede anterograde transport in axons

DuRaine, G., Wisner, T. W., Howard, P., Williams, M. & Johnson, D., Jun 1 2017, In : Journal of Virology. 91, 11, e00050-17.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of conserved ABC importers necessary for intracellular survival of Legionella pneumophila in multiple hosts

Lama, A., Drennan, S. L., Johnson, R. C., Rubenstein, G. L. & Cambronne, E., Nov 30 2017, In : Frontiers in cellular and infection microbiology. 7, NOV, 485.

Research output: Contribution to journalArticle

3 Scopus citations

Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia

Lamble, A. J., Dietz, M., Laderas, T., McWeeney, S. & Lind, E., Jan 1 2017, (Accepted/In press) In : Journal of Immunological Methods.

Research output: Contribution to journalArticle

6 Scopus citations

Killing Mycobacterium tuberculosis in vitro: What model systems can teach us

Keiser, T. L. & Purdy, G., Jun 1 2017, In : Microbiology spectrum. 5, 3, TBTB2-0028-2016.

Research output: Contribution to journalArticle

3 Scopus citations

Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection

Loo, C. P., Nelson, N. A., Lane, R. S., Booth, J. L., Loprinzi Hardin, S. C., Thomas, A., Slifka, M., Nolz, J. & Lund, A., Sep 26 2017, In : Cell Reports. 20, 13, p. 3176-3187 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

Lee, S., Wilen, C. B., Orvedahl, A., McCune, B. T., Kim, K. W., Orchard, R. C., Peterson, S. T., Nice, T., Baldridge, M. T. & Virgin, H. W., 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

31 Scopus citations

Noroviruses co-opt the function of host proteins VAPA and VAPB for replication via a phenylalanine–phenylalanine- acidic-tract-motif mimic in nonstructural viral protein NS1/2

McCune, B. T., Tang, W., Lu, J., Eaglesham, J. B., Thorne, L., Mayer, A. E., Condiff, E., Nice, T. J., Goodfellow, I., Krezel, A. M. & Virgin, H. W., Jul 1 2017, In : mBio. 8, 4, e00668-17.

Research output: Contribution to journalArticle

24 Scopus citations

Preclinical Development of a Prophylactic Neuroprotective Therapy for the Preventive Treatment of Anticipated Ischemia-Reperfusion Injury

Bahjat, F., Alexander West, G., Kohama, S., Glynn, C., Urbanski, H., Hobbs, T., Earl, E., Stevens, S. L. & Stenzel-Poore, M., Apr 5 2017, (Accepted/In press) In : Translational Stroke Research. p. 1-12 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Site-directed RNA repair of endogenous Mecp2 RNA in neurons

Sinnamon, J. R., Kim, S. Y., Corson, G. M., Song, Z., Nakai, H., Adelman, J. & Mandel, G., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. E9395-E9402

Research output: Contribution to journalArticle

20 Scopus citations

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol, M., Panatala, R., Nordmann, M., Swart, L., Van Suijlekom, L., Cabukusta, B., Hilderink, A., Grabietz, T., Mina, J. G. M., Somerharju, P., Korneev, S., Tafesse, F. G. & Holthuis, J. C. M., May 2017, In : Journal of lipid research. 58, 5, p. 962-973 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

The domestic cat antibody response to feline herpesvirus-1 increases with age

Munks, M., Montoya, A. M., Pywell, C. M., Talmage, G., Forssen, A., Campbell, T. L., Dodge, D. D., Kappler, J. W. & Marrack, P., Jun 1 2017, In : Veterinary Immunology and Immunopathology. 188, p. 65-70 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth, and nonreplicating persistence

Wright, C. C., Hsu, F. F., Arnett, E., Dunaj, J. L., Davidson, P. M., Pacheco, S. A., Harriff, M., Lewinsohn, D., Schlesinger, L. S. & Purdy, G., Aug 1 2017, In : Infection and Immunity. 85, 8, 00131-17.

Research output: Contribution to journalArticle

23 Scopus citations

The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection

Cromwell, E. A., Stoddard, S. T., Barker, C. M., Van Rie, A., Messer, W. B., Meshnick, S. R., Morrison, A. C. & Scott, T. W., Mar 23 2017, In : PLoS neglected tropical diseases. 11, 3, e0005429.

Research output: Contribution to journalArticle

29 Scopus citations

The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus

Nice, T., Robinson, B. A. & Van Winkle, J. A., Jan 1 2017, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

8 Scopus citations

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects

Choo, M. K., Sano, Y., Kim, C., Yasuda, K., Li, X. D., Lin, X., Stenzel-Poore, M., Alexopoulou, L., Ghosh, S., Latz, E., Rifkin, I. R., Chen, Z. J., Stewart, G. C., Chong, H. & Park, J. M., May 1 2017, In : Journal of Experimental Medicine. 214, 5, p. 1297-1311 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Translational Stroke Research: Vision and Opportunities

Bosetti, F., Koenig, J. I., Ayata, C., Back, S., Becker, K., Broderick, J. P., Carmichael, T. T., Cho, S., Cipolla, M. J., Corbett, D., Corriveau, R. A., Cramer, S. C., Ferguson, A. R., Finklestein, S. P., Ford, B. D., Furie, K. L., Hemmen, T. M., Iadecola, C., Jakeman, L. B., Janis, S. & 22 others, Jauch, E. C., Johnston, K. C., Kochanek, P. M., Kohn, H., Lo, E. H., Lyden, P. D., Mallard, C., McCullough, L. D., McGavern, L. M., Meschia, J. F., Moy, C. S., Perez-Pinzon, M. A., Ramadan, I., Savitz, S. I., Schwamm, L. H., Steinberg, G. K., Stenzel-Poore, M., Tymianski, M., Warach, S., Wechsler, L. R., Zhang, J. H. & Koroshetz, W., Jul 27 2017, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

28 Scopus citations

Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype

Widman, D. G., Young, E., Nivarthi, U., Swanstrom, J. A., Royal, S. R., Yount, B. L., Debbink, K., Begley, M., Marcet, S., Durbin, A., De Silva, A. M., Messer, W. B. & Baric, R. S., Dec 1 2017, In : Scientific Reports. 7, 1, 17169.

Research output: Contribution to journalArticle

7 Scopus citations

Visualizing the early stages of phagocytosis

Rashidfarrokhi, A., Richina, V. & Tafesse, F., Feb 3 2017, In : Journal of Visualized Experiments. 2017, 120, e54646.

Research output: Contribution to journalArticle

2 Scopus citations

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues

Hirsch, A., Smith, J. L., Haese, N. N., Broeckel, R. M., Parkins, C. J., Kreklywich, C., De Filippis, V., Denton, M., Smith, P. P., Messer, W., Colgin, L., Ducore, R., Grigsby, P., Hennebold, J., Swanson, T., Legasse, A. W., Axthelm, M., MacAllister, R., Wiley, C. A., Nelson, J. & 1 others, Streblow, D., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006219.

Research output: Contribution to journalArticle

111 Scopus citations
2016

Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties

Alfadhli, A., Mack, A., Harper, L., Berk, S., Ritchie, C. & Barklis, E., Nov 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5618-5625 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men

Adler, S. P., Manganello, A. M., Lee, R., McVoy, M. A., Nixon, D. E., Plotkin, S., Mocarski, E., Cox, J. H., Fast, P. E., Nesterenko, P. A., Murray, S., Hill, A. & Kemble, G., Nov 1 2016, In : Journal of Infectious Diseases. 214, 9, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Atovaquone and ELQ-300 combination therapy as a novel dual-site cytochrome bc1 inhibition strategy for malaria

Stickles, A. M., Smilkstein, M. J., Morrisey, J. M., Li, Y., Forquer, I. P., Kelly, J. X., Pou, S., Winter, R. W., Nilsen, A., Vaidya, A. B. & Riscoe, M., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4853-4859 7 p.

Research output: Contribution to journalArticle

20 Scopus citations