Research Output

2020

Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites

Eberhard, N., Balmer, V., Müller, J., Müller, N., Winter, R., Pou, S., Nilsen, A., Riscoe, M., Francisco, S., Leitao, A., Doggett, J. S. & Hemphill, A., Feb 26 2020, In : Frontiers in Veterinary Science. 7, 96.

Research output: Contribution to journalArticle

Open Access

Immunomodulatory effects of pevonedistat, a NEDD8-activating enzyme inhibitor, in chronic lymphocytic leukemia-derived T cells

Best, S., Lam, V., Liu, T., Bruss, N., Kittai, A., Danilova, O. V., Murray, S., Berger, A., Pennock, N. D., Lind, E. F. & Danilov, A. V., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Improving solubility and oral bioavailability of a novel antimalarial prodrug: comparing spray-dried dispersions with self-emulsifying drug delivery systems

Potharaju, S., Mutyam, S. K., Liu, M., Green, C., Frueh, L., Nilsen, A., Pou, S., Winter, R., Riscoe, M. K. & Shankar, G., May 27 2020, In : Pharmaceutical Development and Technology. 25, 5, p. 625-639 15 p.

Research output: Contribution to journalArticle

Novel endochin-like quinolones exhibit potent in vitro activity against Plasmodium knowlesi but do not synergize with proguanil

Van Schalkwyk, D. A., Riscoe, M. K., Pou, S., Winter, R. W., Nilsen, A., Duffey, M., Moon, R. W. & Sutherland, C. J., May 2020, In : Antimicrobial agents and chemotherapy. 64, 5, e02549-19.

Research output: Contribution to journalArticle

2019

4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

Jeong, S. Y., Hogarth, P., Placzek, A., Gregory, A. M., Fox, R., Zhen, D., Hamada, J., van der Zwaag, M., Lambrechts, R., Jin, H., Nilsen, A., Cobb, J., Pham, T., Gray, N., Ralle, M., Duffy, M., Schwanemann, L., Rai, P., Freed, A., Wakeman, K. & 3 others, Woltjer, R. L., Sibon, O. C. M. & Hayflick, S. J., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10489.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Moshofsky, K. B., Cho, H. J., Wu, G., Romine, K. A., Newman, M. T., Kosaka, Y., McWeeney, S. K. & Lind, E. F., Oct 22 2019, In : Blood Advances. 3, 20, p. 3038-3051 14 p.

Research output: Contribution to journalArticle

Open Access

Analysis of HIV-1 matrix-envelope cytoplasmic tail interactions

Alfadhli, A., Staubus, A. O., Tedbury, P. R., Novikova, M., Freed, E. O. & Barklis, E., Jan 1 2019, In : Journal of virology. 93, 21, e01079-19.

Research output: Contribution to journalArticle

4 Scopus citations

Approaches to interrogating the human memory b-cell and memory-derived antibody repertoire following dengue virus infection

Lyski, Z. L. & Messer, W., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1276.

Research output: Contribution to journalReview article

Open Access

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T. J., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K. & Virgin, H. W., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 845-857.e5

Research output: Contribution to journalArticle

6 Scopus citations

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

Robinson, B. A., Van Winkle, J. A., McCune, B. T., Peters, A. M. & Nice, T., Jul 1 2019, In : PLoS pathogens. 15, 7, e1007940.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62l-mediated lymph node surveillance

Osborn, J. F., Hobbs, S. J., Mooster, J. L., Khan, T. N., Kilgore, A. M., Harbour, J. C. & Nolz, J. C., Mar 2019, In : PLoS pathogens. 15, 3, e1007633.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena, S., Bockelmann, S., Mina, J. G. M., Hassan, D. G., Korneev, S., Razzera, G., Jahn, H., Niekamp, P., Müller, D., Schneider, M., Tafesse, F. G., Marrink, S. J., Melo, M. N. & Holthuis, J. C. M., Dec 1 2019, In : Nature communications. 10, 1, 1832.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

15 Scopus citations

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Cabanes-Creus, M., Ginn, S. L., Amaya, A. K., Liao, S. H. Y., Westhaus, A., Hallwirth, C. V., Wilmott, P., Ward, J., Dilworth, K. L., Santilli, G., Rybicki, A., Nakai, H., Thrasher, A. J., Filip, A. C., Alexander, I. E. & Lisowski, L., Mar 15 2019, In : Molecular Therapy - Methods and Clinical Development. 12, p. 71-84 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D. R., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M. K., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access

Evaluating enzyme activities and structures of DUBs

Pruneda, J. N. & Komander, D., 2019, Methods in Enzymology. Academic Press Inc., p. 321-341 21 p. (Methods in Enzymology; vol. 618).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gasdermin-D and caspase-7 are the key caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of legionella pneumophila

Gonçalves, A. V., Margolis, S. R., Quirino, G. F. S., Mascarenhas, D. P. A., Rauch, I., Nichols, R. D., Ansaldo, E., Fontana, M. F., Vance, R. E. & Zamboni, D. S., Jun 1 2019, In : PLoS pathogens. 15, 6, e1007886.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

Vanarsdall, A., Chin, A. L., Liu, J., Jardetzky, T. S., Mudd, J., Orloff, S., Streblow, D., Mussi-Pinhata, M. M., Yamamoto, A. Y., Duarte, G., Britt, W. J. & Johnson, D., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3728-3733 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

Bryson, B. D., Rosebrock, T. R., Tafesse, F. G., Itoh, C. Y., Nibasumba, A., Babunovic, G. H., Corleis, B., Martin, C., Keegan, C., Andrade, P., Realegeno, S., Kwon, D., Modlin, R. L. & Fortune, S. M., Dec 1 2019, In : Nature communications. 10, 1, 2329.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

IFN-I and IL-22 mediate protective effects of intestinal viral infection

Neil, J. A., Matsuzawa-Ishimoto, Y., Kernbauer-Hölzl, E., Schuster, S. L., Sota, S., Venzon, M., Dallari, S., Galvao Neto, A., Hine, A., Hudesman, D., Loke, P., Nice, T. & Cadwell, K., Jan 1 2019, In : Nature Microbiology.

Research output: Contribution to journalArticle

4 Scopus citations

Insights into ubiquitin chain architecture using Ub-clipping

Swatek, K. N., Usher, J. L., Kueck, A. F., Gladkova, C., Mevissen, T. E. T., Pruneda, J. N., Skern, T. & Komander, D., Aug 22 2019, In : Nature. 572, 7770, p. 533-537 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Legionella dismantles linear ubiquitin

Damgaard, R. B. & Pruneda, J., Aug 1 2019, In : Nature Microbiology. 4, 8, p. 1244-1245 2 p.

Research output: Contribution to journalArticle

Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling

Singh, J. & Aballay, A., Apr 8 2019, In : Developmental Cell. 49, 1, p. 89-99.e4

Research output: Contribution to journalArticle

8 Scopus citations

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

Ke, H., Ganesan, S. M., Dass, S., Morrisey, J. M., Pou, S., Nilsen, A., Riscoe, M., Mather, M. W. & Vaidya, A. B., Apr 1 2019, In : PloS one. 14, 4, e0214023.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

Su, C. C., Klenotic, P. A., Bolla, J. R., Purdy, G., Robinson, C. V. & Yu, E. W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11241-11246 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Melly, G. & Purdy, G. E., Mar 2019, In : Microorganisms. 7, 3, 70.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Multiple-stage precursor ion separation and high resolution mass spectrometry toward structural characterization of 2,3-diacyltrehalose family from mycobacterium tuberculosis

Frankfater, C., Abramovitch, R. B., Purdy, G. E., Turk, J., Legentil, L., Lemiègre, L. & Hsu, F. F., Mar 2019, In : Separations. 6, 1, 4.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

Barklis, E., Stephen, A. G., Staubus, A. O., Barklis, R. L. & Alfadhli, A., Jan 1 2019, In : Journal of molecular biology.

Research output: Contribution to journalArticle

1 Scopus citations

Preconditioning in the Rhesus Macaque Induces a Proteomic Signature Following Cerebral Ischemia that Is Associated with Neuroprotection

Stevens, S. L., Liu, T., Bahjat, F. R., Petyuk, V. A., Schepmoes, A. A., Sontag, R. L., Gritsenko, M. A., Wu, C., Wang, S., Shukla, A. K., Jacobs, J. M., Smith, R. D., Rodland, K. D., Alexander West, G., Kohama, S. G., Glynn, C. & Stenzel-Poore, M. P., Aug 15 2019, In : Translational Stroke Research. 10, 4, p. 440-448 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protean permeases: Diverse roles for membrane transport proteins in kinetoplastid protozoa

Landfear, S., Jan 1 2019, In : Molecular and Biochemical Parasitology. 227, p. 39-46 8 p.

Research output: Contribution to journalReview article

Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells

Staubus, A. O., Alfadhli, A., Barklis, R. L. & Barklis, E., Dec 2019, In : Virology. 538, p. 1-10 10 p.

Research output: Contribution to journalArticle

Role of neurons in the control of immune defense

Hoffman, C. & Aballay, A., Oct 1 2019, In : Current opinion in immunology. 60, p. 30-36 7 p.

Research output: Contribution to journalReview article

5 Scopus citations

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

Shi, Z., Zou, J., Zhang, Z., Zhao, X., Noriega, J., Zhang, B., Zhao, C., Ingle, H., Bittinger, K., Mattei, L. M., Pruijssers, A. J., Plemper, R. K., Nice, T. J., Baldridge, M. T., Dermody, T. S., Chassaing, B. & Gewirtz, A. T., Oct 17 2019, In : Cell. 179, 3, p. 644-658.e13

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Sensing What's Out There – Kinetoplastid Parasites

Landfear, S. & Zilberstein, D., Jan 1 2019, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Similar neural pathways control foraging in mosquitoes and worms

Singh, J. & Aballay, A., Mar 1 2019, In : mBio. 10, 2, e00656-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis

Melly, G. C., Stokas, H., Dunaj, J. L., Hsu, F. F., Rajavel, M., Su, C. C., Yu, E. W. & Purdy, G. E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 43, p. 15711-15723 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters

Eshleman, A. J., Nagarajan, S., Wolfrum, K. M., Reed, J. F., Swanson, T. L., Nilsen, A. & Janowsky, A., Mar 1 2019, In : Psychopharmacology. 236, 3, p. 939-952 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The brief case: Klebsiella variicola-identifying the misidentified

Fontana, L., Bonura, E., Lyski, Z. & Messer, W., Jan 1 2019, In : Journal of Clinical Microbiology. 57, 1, e00826.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus

Hobbs, S. J., Osborn, J. F. & Nolz, J., Feb 1 2018, In : Current Opinion in Virology. 28, p. 12-19 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Gimenez, V. M. M., Alvarenga, T. A., Groppo, M., Silva, M. L. A. E., Cunha, W. R., Januário, A. H., Smilkstein, M. J., Riscoe, M. & Pauletti, P. M., Jan 1 2018, (Accepted/In press) In : Brazilian Journal of Pharmacognosy.

Research output: Contribution to journalArticle

A quantitative dot blot assay for AAV titration and its use for functional assessment of the adeno-associated virus assembly-activating proteins

Powers, J. M., Chang, X. L., Song, Z. & Nakai, H., Jun 12 2018, In : Journal of Visualized Experiments. 2018, 136, e56766.

Research output: Contribution to journalArticle

CD147 promotes entry of pentamer-expressing human cytomegalovirus into epithelial and endothelial cells

Vanarsdall, A., Pritchard, S. R., Wisner, T. W., Liu, J., Jardetzky, T. S. & Johnson, D., May 1 2018, In : mBio. 9, 3, e00781-18.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

Smith, J. L., Sheridan, K., Parkins, C. J., Frueh, L., Jemison, A. L., Strode, K., Dow, G., Nilsen, A. & Hirsch, A., Jul 1 2018, In : Antiviral Research. 155, p. 12-19 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

Klammt, J., Neumann, D., Gevers, E. F., Andrew, S. F., Schwartz, I. D., Rockstroh, D., Colombo, R., Sanchez, M. A., Vokurkova, D., Kowalczyk, J., Metherell, L. A., Rosenfeld, R. G., Pfäffle, R., Dattani, M. T., Dauber, A. & Hwa, V., Dec 1 2018, In : Nature communications. 9, 1, 8329.

Research output: Contribution to journalArticle

22 Scopus citations

Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway

Gall, B., Pryke, K., Abraham, J., Mizuno, N., Botto, S., Sali, T. M., Broeckel, R., Haese, N., Nilsen, A., Placzek, A., Morrison, T., Heise, M., Streblow, D. & De Filippis, V., Mar 1 2018, In : Journal of Virology. 92, 6, e01913-17.

Research output: Contribution to journalArticle

9 Scopus citations

Endochin-like quinolones exhibit promising efficacy against neospora caninum in vitro and in experimentally infected pregnant mice

Anghel, N., Balmer, V., Müller, J., Winzer, P., Aguado-Martinez, A., Roozbehani, M., Pou, S., Nilsen, A., Riscoe, M., Doggett, J. & Hemphill, A., Nov 19 2018, In : Frontiers in Veterinary Science. 5, NOV, 285.

Research output: Contribution to journalArticle

2 Scopus citations

Functional analysis of Leishmania membrane (Non-ABC) transporters involved in drug resistance

Landfear, S., Aug 23 2018, Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer International Publishing, p. 273-294 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter