Research Output 1969 2019

2019

4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

Jeong, S. Y., Hogarth, P., Placzek, A., Gregory, A. M., Fox, R., Zhen, D., Hamada, J., van der Zwaag, M., Lambrechts, R., Jin, H., Nilsen, A., Cobb, J., Pham, T., Gray, N., Ralle, M., Duffy, M., Schwanemann, L., Rai, P., Freed, A., Wakeman, K. & 3 others, Woltjer, R. L., Sibon, O. C. M. & Hayflick, S. J., Jan 1 2019, (Accepted/In press) In : EMBO Molecular Medicine. e10489.

Research output: Contribution to journalArticle

Open Access
Pantothenate Kinase-Associated Neurodegeneration
Coenzyme A
Dopamine
Iron
Biomarkers

Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Moshofsky, K. B., Cho, H. J., Wu, G., Romine, K. A., Newman, M. T., Kosaka, Y., McWeeney, S. K. & Lind, E. F., Oct 22 2019, In : Blood Advances. 3, 20, p. 3038-3051 14 p.

Research output: Contribution to journalArticle

Open Access
T-Lymphocytes
Acute Myeloid Leukemia
Mitogen-Activated Protein Kinase Kinases
Programmed Cell Death 1 Ligand 2 Protein
Cell Death

Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions

Alfadhli, A., Staubus, A. O., Tedbury, P. R., Novikova, M., Freed, E. O. & Barklis, E., Nov 1 2019, In : Journal of virology. 93, 21

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
gag Gene Products
HIV-1
tail
Virion

Approaches to interrogating the human memory b-cell and memory-derived antibody repertoire following dengue virus infection

Lyski, Z. L. & Messer, W., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1276.

Research output: Contribution to journalReview article

Open Access
Dengue Virus
Virus Diseases
B-Lymphocytes
Antibodies
Viruses
4 Citations (Scopus)

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K. & Virgin, H. W., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 845-857.e5

Research output: Contribution to journalArticle

Viral Nonstructural Proteins
Norovirus
Enterovirus
Vaccination
Vaccines
2 Citations (Scopus)

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

Robinson, B. A., Van Winkle, J. A., McCune, B. T., Peters, A. M. & Nice, T., Jul 1 2019, In : PLoS pathogens. 15, 7, e1007940.

Research output: Contribution to journalArticle

Open Access
Norovirus
Caspases
Epithelial Cells
Apoptosis
Infection
2 Citations (Scopus)

Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance

Osborn, J. F., Hobbs, S. J., Mooster, J. L., Khan, T. N., Kilgore, A. M., Harbour, J. C. & Nolz, J., Mar 1 2019, In : PLoS pathogens. 15, 3, p. e1007633

Research output: Contribution to journalArticle

Open Access
Virus Diseases
Lymph Nodes
T-Lymphocytes
Skin
Immunity
6 Citations (Scopus)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena, S., Bockelmann, S., Mina, J. G. M., Hassan, D. G., Korneev, S., Razzera, G., Jahn, H., Niekamp, P., Müller, D., Schneider, M., Tafesse, F., Marrink, S. J., Melo, M. N. & Holthuis, J. C. M., Dec 1 2019, In : Nature communications. 10, 1, 1832.

Research output: Contribution to journalArticle

Open Access
Ceramides
apoptosis
glutamates
actuators
Apoptosis
9 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Cabanes-Creus, M., Ginn, S. L., Amaya, A. K., Liao, S. H. Y., Westhaus, A., Hallwirth, C. V., Wilmott, P., Ward, J., Dilworth, K. L., Santilli, G., Rybicki, A., Nakai, H., Thrasher, A. J., Filip, A. C., Alexander, I. E. & Lisowski, L., Mar 15 2019, In : Molecular Therapy - Methods and Clinical Development. 12, p. 71-84 14 p.

Research output: Contribution to journalArticle

DNA Shuffling
Dependovirus
Capsid
Codon
Tropism

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access
Malaria
Prodrugs
Plasmodium yoelii
Pharmacokinetics
Sporozoites

Evaluating enzyme activities and structures of DUBs

Pruneda, J. & Komander, D., Jan 1 2019, Methods in Enzymology. Academic Press Inc., p. 321-341 21 p. (Methods in Enzymology; vol. 618).

Research output: Chapter in Book/Report/Conference proceedingChapter

Enzyme activity
Ubiquitin
Enzymes
Substrates
Viruses
3 Citations (Scopus)

Gasdermin-D and caspase-7 are the key caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of legionella pneumophila

Gonçalves, A. V., Margolis, S. R., Quirino, G. F. S., Mascarenhas, D. P. A., Rauch, I., Nichols, R. D., Ansaldo, E., Fontana, M. F., Vance, R. E. & Zamboni, D. S., Jun 1 2019, In : PLoS pathogens. 15, 6, e1007886.

Research output: Contribution to journalArticle

Open Access
Inflammasomes
Caspase 7
Legionella pneumophila
Caspase 1
Caspase 8
1 Citation (Scopus)

HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

Vanarsdall, A., Chin, A. L., Liu, J., Jardetzky, T. S., Mudd, J., Orloff, S., Streblow, D., Mussi-Pinhata, M. M., Yamamoto, A. Y., Duarte, G., Britt, W. J. & Johnson, D., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3728-3733 6 p.

Research output: Contribution to journalArticle

Open Access
Cytomegalovirus
Neutralizing Antibodies
Viruses
Antibodies
Mothers
1 Citation (Scopus)

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

Bryson, B. D., Rosebrock, T. R., Tafesse, F., Itoh, C. Y., Nibasumba, A., Babunovic, G. H., Corleis, B., Martin, C., Keegan, C., Andrade, P., Realegeno, S., Kwon, D., Modlin, R. L. & Fortune, S. M., Dec 1 2019, In : Nature communications. 10, 1, 2329.

Research output: Contribution to journalArticle

Open Access
tuberculosis
macrophages
Macrophages
Granulocyte-Macrophage Colony-Stimulating Factor
Mycobacterium tuberculosis
1 Citation (Scopus)

IFN-I and IL-22 mediate protective effects of intestinal viral infection

Neil, J. A., Matsuzawa-Ishimoto, Y., Kernbauer-Hölzl, E., Schuster, S. L., Sota, S., Venzon, M., Dallari, S., Galvao Neto, A., Hine, A., Hudesman, D., Loke, P., Nice, T. & Cadwell, K., Jan 1 2019, In : Nature Microbiology.

Research output: Contribution to journalArticle

Norovirus
Virus Diseases
Citrobacter rodentium
Epithelial Cells
Interferon Type I
1 Citation (Scopus)

Insights into ubiquitin chain architecture using Ub-clipping

Swatek, K. N., Usher, J. L., Kueck, A. F., Gladkova, C., Mevissen, T. E. T., Pruneda, J., Skern, T. & Komander, D., Aug 22 2019, In : Nature. 572, 7770, p. 533-537 5 p.

Research output: Contribution to journalLetter

Ubiquitin
Polyubiquitin
Ubiquitination
Mitochondrial Degradation
Dipeptides

Legionella dismantles linear ubiquitin

Damgaard, R. B. & Pruneda, J., Aug 1 2019, In : Nature Microbiology. 4, 8, p. 1244-1245 2 p.

Research output: Contribution to journalArticle

Legionella
Ubiquitin
Legionnaires' Disease
Legionella pneumophila
Bacterial Infections
5 Citations (Scopus)

Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling

Singh, J. & Aballay, A., Apr 8 2019, In : Developmental Cell. 49, 1, p. 89-99.e4

Research output: Contribution to journalArticle

Genes
Caenorhabditis elegans
Intestines
Pathogens
Aptitude
4 Citations (Scopus)

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages

Ke, H., Ganesan, S. M., Dass, S., Morrisey, J. M., Pou, S., Nilsen, A., Riscoe, M., Mather, M. W. & Vaidya, A. B., Apr 1 2019, In : PloS one. 14, 4, e0214023.

Research output: Contribution to journalArticle

Open Access
NADH dehydrogenase
Plasmodium falciparum
Parasites
antimalarials
Blood
5 Citations (Scopus)

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

Su, C. C., Klenotic, P. A., Bolla, J. R., Purdy, G., Robinson, C. V. & Yu, E. W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11241-11246 6 p.

Research output: Contribution to journalArticle

Membrane Proteins
Lipids
Cord Factors
Mycolic Acids
Cell Wall
5 Citations (Scopus)

Mmpl proteins in physiology and pathogenesis of m. Tuberculosis

Melly, G. & Purdy, G. E., Mar 2019, In : Microorganisms. 7, 3, 70.

Research output: Contribution to journalArticle

Open Access
Mycobacterium tuberculosis
Tuberculosis
Virulence
Membrane Proteins
Proteins

Multiple-stage precursor ion separation and high resolution mass spectrometry toward structural characterization of 2,3-diacyltrehalose family from mycobacterium tuberculosis

Frankfater, C., Abramovitch, R. B., Purdy, G., Turk, J., Legentil, L., Lemiègre, L. & Hsu, F. F., Mar 1 2019, In : Separations. 6, 1, 4.

Research output: Contribution to journalArticle

Open Access
Trehalose
Mass spectrometry
Ions
Stereoisomerism
Complex Mixtures

Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

Barklis, E., Stephen, A. G., Staubus, A. O., Barklis, R. L. & Alfadhli, A., Jan 1 2019, In : Journal of molecular biology.

Research output: Contribution to journalArticle

Membranes
Proteins
Prenylation
ras Proteins
Post Translational Protein Processing

Protean permeases: Diverse roles for membrane transport proteins in kinetoplastid protozoa

Landfear, S., Jan 1 2019, In : Molecular and Biochemical Parasitology. 227, p. 39-46 8 p.

Research output: Contribution to journalReview article

Membrane Transport Proteins
Parasites
Food
Membrane Proteins
Trypanosoma brucei brucei

Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells

Staubus, A. O., Alfadhli, A., Barklis, R. L. & Barklis, E., Dec 2019, In : Virology. 538, p. 1-10 10 p.

Research output: Contribution to journalArticle

HIV-1
Cell Membrane
Virion
Proteins
gag Gene Products
3 Citations (Scopus)

Role of neurons in the control of immune defense

Hoffman, C. & Aballay, A., Oct 1 2019, In : Current opinion in immunology. 60, p. 30-36 7 p.

Research output: Contribution to journalReview article

Caenorhabditis elegans
Vertebrates
Neurons
Vagus Nerve
Dissection
1 Citation (Scopus)

Second-Generation Inhibitors of the Mitochondrial Permeability Transition Pore with Improved Plasma Stability

Šileikytė, J., Devereaux, J., de Jong, J., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M. & Cohen, M. S., Oct 17 2019, In : ChemMedChem. 14, 20, p. 1771-1782 12 p.

Research output: Contribution to journalArticle

Plasma stability
Isoxazoles
Triazoles
Click Chemistry
Oxidative stress
2 Citations (Scopus)

Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection

Shi, Z., Zou, J., Zhang, Z., Zhao, X., Noriega, J., Zhang, B., Zhao, C., Ingle, H., Bittinger, K., Mattei, L. M., Pruijssers, A. J., Plemper, R. K., Nice, T. J., Baldridge, M. T., Dermody, T. S., Chassaing, B. & Gewirtz, A. T., Oct 17 2019, In : Cell. 179, 3, p. 644-658.e13

Research output: Contribution to journalArticle

Open Access
Rotavirus Infections
Rotavirus
Bacteria
Transplants
Microbiota

Sensing What's Out There – Kinetoplastid Parasites

Landfear, S. & Zilberstein, D., Jan 1 2019, (Accepted/In press) In : Trends in Parasitology.

Research output: Contribution to journalArticle

Parasites
Trypanosomiasis
Leishmania
Signal Transduction
Membrane Proteins
1 Citation (Scopus)

Similar neural pathways control foraging in mosquitoes and worms

Singh, J. & Aballay, A., Mar 1 2019, In : mBio. 10, 2, e00656-19.

Research output: Contribution to journalArticle

Open Access
Neural Pathways
Neuropeptide Y Receptors
Culicidae
Disease Vectors
Caenorhabditis elegans

Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis

Melly, G. C., Stokas, H., Dunaj, J. L., Hsu, F. F., Rajavel, M., Su, C. C., Yu, E. W. & Purdy, G. E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 43, p. 15711-15723 13 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Lipoproteins
Lipids
Membrane Proteins
Proteins

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Assays
mitochondria
therapeutics
neoplasms
2 Citations (Scopus)

The brief case: Klebsiella variicola-identifying the misidentified

Fontana, L., Bonura, E., Lyski, Z. & Messer, W., Jan 1 2019, In : Journal of Clinical Microbiology. 57, 1, e00826.

Research output: Contribution to journalArticle

Klebsiella
2018
2 Citations (Scopus)

Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus

Hobbs, S. J., Osborn, J. F. & Nolz, J., Feb 1 2018, In : Current Opinion in Virology. 28, p. 12-19 8 p.

Research output: Contribution to journalReview article

Vaccinia virus
Virus Diseases
T-Lymphocytes
Skin
Immunologic Memory

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols

Gimenez, V. M. M., Alvarenga, T. A., Groppo, M., Silva, M. L. A. E., Cunha, W. R., Januário, A. H., Smilkstein, M. J., Riscoe, M. & Pauletti, P. M., Jan 1 2018, (Accepted/In press) In : Brazilian Journal of Pharmacognosy.

Research output: Contribution to journalArticle

Anacardium
Phenols
Inhibitory Concentration 50
Anacardic Acids
Ethanol

A quantitative dot blot assay for AAV titration and its use for functional assessment of the adeno-associated virus assembly-activating proteins

Powers, J. M., Chang, X. L., Song, Z. & Nakai, H., Jun 12 2018, In : Journal of Visualized Experiments. 2018, 136, e56766.

Research output: Contribution to journalArticle

Functional assessment
Virus Assembly
Dependovirus
Titration
Viruses
9 Citations (Scopus)

CD147 promotes entry of pentamer-expressing human cytomegalovirus into epithelial and endothelial cells

Vanarsdall, A., Pritchard, S. R., Wisner, T. W., Liu, J., Jardetzky, T. S. & Johnson, D., May 1 2018, In : mBio. 9, 3, e00781-18.

Research output: Contribution to journalArticle

Cytomegalovirus
Endothelial Cells
Epithelial Cells
Fibroblasts
Glycoproteins
2 Citations (Scopus)

Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions

Smith, J. L., Sheridan, K., Parkins, C. J., Frueh, L., Jemison, A. L., Strode, K., Dow, G., Nilsen, A. & Hirsch, A., Jul 1 2018, In : Antiviral Research. 155, p. 12-19 8 p.

Research output: Contribution to journalArticle

Dengue Virus
Capsid Proteins
Structure-Activity Relationship
Virion
Antiviral Agents
15 Citations (Scopus)

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

Klammt, J., Neumann, D., Gevers, E. F., Andrew, S. F., Schwartz, I. D., Rockstroh, D., Colombo, R., Sanchez, M., Vokurkova, D., Kowalczyk, J., Metherell, L. A., Rosenfeld, R. R., Pfäffle, R., Dattani, M. T., Dauber, A. & Hwa, V., Dec 1 2018, In : Nature Communications. 9, 1, 8329.

Research output: Contribution to journalArticle

Laron Syndrome
pituitary hormones
mutations
Transducers
Growth Hormone
4 Citations (Scopus)

Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway

Gall, B., Pryke, K., Abraham, J., Mizuno, N., Botto, S., Sali, T. M., Broeckel, R., Haese, N., Nilsen, A., Placzek, A., Morrison, T., Heise, M., Streblow, D. & De Filippis, V., Mar 1 2018, In : Journal of Virology. 92, 6, e01913-17.

Research output: Contribution to journalArticle

Alphavirus
interferons
Interferons
agonists
Interferon Type I

Endochin-like quinolones exhibit promising efficacy against neospora caninum in vitro and in experimentally infected pregnant mice

Anghel, N., Balmer, V., Müller, J., Winzer, P., Aguado-Martinez, A., Roozbehani, M., Pou, S., Nilsen, A., Riscoe, M., Doggett, J. & Hemphill, A., Nov 19 2018, In : Frontiers in Veterinary Science. 5, NOV, 285.

Research output: Contribution to journalArticle

Neospora
quinolones
Neospora caninum
Quinolones
mice

Functional analysis of Leishmania membrane (Non-ABC) transporters involved in drug resistance

Landfear, S., Aug 23 2018, Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments. Springer International Publishing, p. 273-294 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Leishmania
Drug Resistance
Membrane Transport Proteins
Parasites
Membranes
2 Citations (Scopus)

Glucose Transporters and Virulence in Leishmania mexicana

Feng, X., Tran, K. D., Sanchez, M., Al Mezewghi, H. & Landfear, S., Aug 1 2018, In : mSphere. 3, 4

Research output: Contribution to journalArticle

Leishmania mexicana
Facilitative Glucose Transport Proteins
Virulence
Macrophages
Parasites
4 Citations (Scopus)

HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection

MacDuff, D. A., Baldridge, M. T., Qaqish, A. M., Nice, T., Darbandi, A. D., Hartley, V. L., Peterson, S. T., Miner, J. J., Iwai, K. & Virgin, H. W., Dec 1 2018, In : Journal of Virology. 92, 23

Research output: Contribution to journalArticle

Norovirus
Interferon Type I
heme
interferons
Ligases
1 Citation (Scopus)

Kinesin-1 Proteins KIF5A, -5B, and -5C promote anterograde transport of herpes simplex virus enveloped virions in axons

DuRaine, G., Wisner, T. W., Howard, P. & Johnson, D., Oct 1 2018, In : Journal of Virology. 92, 20, e01269.

Research output: Contribution to journalArticle

herpes simplex
Kinesin
kinesin
Simplexvirus
virion
8 Citations (Scopus)

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Saunders, E. C., Naderer, T., Chambers, J., Landfear, S. & Mcconville, M. J., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

Leishmania mexicana
Carbon
Animal Models
Macrophages
Amino Acids
2 Citations (Scopus)

Lipid biosensor interactions with wild type and matrix deletion HIV-1 Gag proteins

Barklis, E., Staubus, A. O., Mack, A., Harper, L., Barklis, R. L. & Alfadhli, A., May 1 2018, In : Virology. 518, p. 264-271 8 p.

Research output: Contribution to journalArticle

gag Gene Products
Biosensing Techniques
HIV-1
Lipids
Viral Proteins
7 Citations (Scopus)

Lipids and pathogenic flaviviruses: An intimate union

Leier, H. C., Messer, W. & Tafesse, F., May 1 2018, In : PLoS Pathogens. 14, 5, e1006952.

Research output: Contribution to journalArticle

Flavivirus
Lipids
12 Citations (Scopus)

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

Harriff, M., McMurtrey, C., Froyd, C. A., Jin, H., Cansler, M., Null, M., Worley, A., Meermeier, E. W., Swarbrick, G., Nilsen, A., Lewinsohn, D., Hildebrand, W., Adams, E. J. & Lewinsohn, D., Jul 13 2018, In : Science immunology. 3, 25

Research output: Contribution to journalArticle

Metabolome
T-Cell Antigen Receptor
Ligands
Mycobacterium smegmatis
T-Lymphocyte Subsets