Molecular & Medical Genetics

Organization profile

Organization profile

The Molecular and Medical Genetics (MMG) Department is an interdisciplinary group of faculty performing basic laboratory research, clinical research, teaching of both graduate and medical students, overseeing the operation of several clinical labs and providing expertise in the area of clinical genetics care.

Fingerprint Dive into the research topics where Molecular & Medical Genetics is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Mutation Medicine & Life Sciences
Pantothenate Kinase-Associated Neurodegeneration Medicine & Life Sciences
Genes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Fanconi Anemia Medicine & Life Sciences
DNA Mismatch Repair Medicine & Life Sciences
Proteins Medicine & Life Sciences
Phenylketonurias Medicine & Life Sciences

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Profiles

No photo of Andrew Adey

Andrew Adey

Person: Academic

20102019
No photo of Mushui Dai

Mushui Dai

Person: Academic

19982020
No photo of Amy Farrell

Amy Farrell

Person: Academic

20092017

Projects 1976 2021

Deubiquitination regulation of c-Myc

Sears, R. & Dai, M.

National Institutes of Health

4/1/15 → 3/31/20

Project: Research project

Ubiquitination
Ubiquitin
Phosphorylation
Ligases
Carcinogenesis

Novel therapy for monoamine neurotransmitter deficiency in PKU

Harding, C.

National Institutes of Health

9/30/12 → 5/31/21

Project: Research project

Phenylketonurias
Neurotransmitter Agents
Serotonin
Brain
Dopamine

HYPOHIDROTIC ECTODERMAL DYSPLASIA GENE

Zonana, J. (.

National Institutes of Health

3/7/96 → …

Project: Research project

Anhidrotic Ectodermal Dysplasia 1
Ectodermal Dysplasia
Genes
Gene Library
Mutation

Research Output 1981 2019

1 Citation (Scopus)

4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

Jeong, S. Y., Hogarth, P., Placzek, A., Gregory, A. M., Fox, R., Zhen, D., Hamada, J., van der Zwaag, M., Lambrechts, R., Jin, H., Nilsen, A., Cobb, J., Pham, T., Gray, N., Ralle, M., Duffy, M., Schwanemann, L., Rai, P., Freed, A., Wakeman, K. & 3 others, Woltjer, R. L., Sibon, O. C. M. & Hayflick, S. J., Jan 1 2019, (Accepted/In press) In : EMBO Molecular Medicine. e10489.

Research output: Contribution to journal › Article

Open Access
Pantothenate Kinase-Associated Neurodegeneration
Coenzyme A
Dopamine
Iron
Biomarkers

A case of recurrent epilepsy-associated rosette-forming glioneuronal tumor with anaplastic transformation in the absence of therapy

Halfpenny, A., Ferris, S. P., Grafe, M., Woltjer, R. R., Selden, N., Nazemi, K., Perry, A., Solomon, D. A., Gultekin, S., Moore, S., Olson, S., Lawce, H., Lucas, L., Corless, C. & Wood, M., Jan 1 2019, (Accepted/In press) In : Neuropathology.

Research output: Contribution to journal › Article

Open Access
Epilepsy
Neuroepithelial Neoplasms
Fluorescence In Situ Hybridization
Neoplasms
Temporal Lobe
11 Citations (Scopus)

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G. & Sears, R., Jan 1 2019, In : Cancer Research. 79, 1, p. 209-219 11 p.

Research output: Contribution to journal › Article

Protein Phosphatase 2
Adenocarcinoma
Phosphoric Monoester Hydrolases
Phosphotransferases
Growth