Organization profile

Organization profile

The Molecular and Medical Genetics (MMG) Department is an interdisciplinary group of faculty performing basic laboratory research, clinical research, teaching of both graduate and medical students, overseeing the operation of several clinical labs and providing expertise in the area of clinical genetics care.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Mutation Medicine & Life Sciences
Genes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
DNA Medicine & Life Sciences
DNA Mismatch Repair Medicine & Life Sciences
Fanconi Anemia Medicine & Life Sciences

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Projects 1976 2021

Insulin Resistance
Fatty Acids
Metabolomics
Type 2 Diabetes Mellitus
Oxidoreductases

In vivo targeting of diabetes-relevant human cell types with rAAV vectors

Grompe, M., Nakai, H. & Kay, M.

National Institutes of Health

9/30/146/30/19

Project: Research projectHigh Impact Research and Research Infrastructure Cooperative Agreement Programs—Multi-Yr Funding

Dependovirus
Capsid
MicroRNAs
Epithelium
Therapeutics
Immune Evasion
Dependovirus
Capsid
Primates
Blood-Brain Barrier

Research Output 1981 2017

Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

Di Meo, I. , Colombelli, C. , Srinivasan, B. , De Villiers, M. , Hamada, J. , Jeong, S. Y. , Fox, R. , Woltjer, R. L. , Tepper, P. G. , Lahaye, L. L. , Rizzetto, E. , Harrs, C. H. , De Boer, T. , Van Der Zwaag, M. , Jenko, B. , Čusak, A. , Pahor, J. , Kosec, G. , Grzeschik, N. A. , Hayflick, S. J. & 2 others Tiranti, V. & Sibon, O. C. M. Dec 1 2017 In : Scientific Reports. 7, 1, 11260

Research output: Research - peer-reviewArticle

Coenzyme A
Phenotype
Serum
pantothenate kinase
4'-phosphopantetheine
2 Citations

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

Sangodkar, J. , Perl, A. , Tohme, R. , Kiselar, J. , Kastrinsky, D. B. , Zaware, N. , Izadmehr, S. , Mazhar, S. , Wiredja, D. D. , O'Connor, C. M. , Hoon, D. , Dhawan, N. S. , Schlatzer, D. , Yao, S. , Leonard, D. , Borczuk, A. C. , Gokulrangan, G. , Wang, L. , Svenson, E. , Farrington, C. C. & 25 others Yuan, E., Avelar, R. A., Stachnik, A., Smith, B., Gidwani, V., Giannini, H. M., McQuaid, D., McClinch, K., Wang, Z., Levine, A. C., Sears, R. C., Chen, E. Y., Duan, Q., Datt, M., Haider, S., Ma'Ayan, A., DiFeo, A., Sharma, N., Galsky, M. D., Brautigan, D. L., Ioannou, Y. A., Xu, W., Chance, M. R., Ohlmeyer, M. & Narla, G. Jun 1 2017 In : Journal of Clinical Investigation. 127, 6, p. 2081-2090 10 p.

Research output: Research - peer-reviewArticle

Tumor Suppressor Proteins
Protein Phosphatase 2
Growth
Neoplasms
Phosphotransferases
6 Citations

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. S. & Nakai, H. 2017 In : Journal of Virology. 91, 3, e01980-16

Research output: Research - peer-reviewArticle

Virus Assembly
Dependovirus
Capsid
Proteins
Serogroup