Division of Bioinformatics and Computational Biology

Research Output 2010 2019

2019

Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Moshofsky, K. B., Cho, H. J., Wu, G., Romine, K. A., Newman, M. T., Kosaka, Y., McWeeney, S. K. & Lind, E. F., Oct 22 2019, In : Blood Advances. 3, 20, p. 3038-3051 14 p.

Research output: Contribution to journalArticle

Open Access
T-Lymphocytes
Acute Myeloid Leukemia
Mitogen-Activated Protein Kinase Kinases
Programmed Cell Death 1 Ligand 2 Protein
Cell Death
12 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors
9 Citations (Scopus)

Controlling for contaminants in low-biomass 16S rRNA gene sequencing experiments

Karstens, L., Asquith, M., Davin, S., Fair, D., Gregory, W. T., Wolfe, A. J., Braun, J. & McWeeney, S., Jul 1 2019, In : mSystems. 4, 4, e00290-19.

Research output: Contribution to journalArticle

Open Access
Biomass
rRNA Genes
Sequencing
microbial communities
Genes

Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma

Choonoo, G., Blucher, A. S., Higgins, S., Boardman, M., Jeng, S., Zheng, C., Jacobs, J., Anderson, A., Chamberlin, S., Evans, N., Vigoda, M., Cordier, B., Tyner, J. W., Kulesz-Martin, M., McWeeney, S. K. & Laderas, T., Jan 1 2019, In : PloS one. 14, 10, e0223639.

Research output: Contribution to journalArticle

Open Access
squamous cell carcinoma
Drug Delivery Systems
neck
drugs
neoplasms
2 Citations (Scopus)

Natural product target network reveals potential for cancer combination therapies

Chamberlin, S. R., Blucher, A., Wu, G., Shinto, L., Choonoo, G., Kulesz-Martin, M. & McWeeney, S., Jan 1 2019, In : Frontiers in Pharmacology. 10, MAY, 557.

Research output: Contribution to journalArticle

Open Access
Biological Products
Neoplasms
Therapeutics
Drug Interactions
Pharmaceutical Preparations

Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance

Michaelis, K. A., Norgard, M. A., Levasseur, P. R., Olson, B., Burfeind, K. G., Buenafe, A. C., Zhu, X., Jeng, S., McWeeney, S. & Marks, D., Jan 1 2019, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Open Access
resiquimod
Toll-Like Receptor 7
Immune Tolerance
Microglia
Lipopolysaccharides
1 Citation (Scopus)

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

Drusbosky, L. M., Vidva, R., Gera, S., Lakshminarayana, A. V., Shyamasundar, V. P., Agrawal, A. K., Talawdekar, A., Abbasi, T., Vali, S., Tognon, C. E., Kurtz, S. E., Tyner, J., McWeeney, S., Druker, B. & Cogle, C. R., Feb 1 2019, In : Leukemia Research. 77, p. 42-50 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Genomics
Computational Biology
MAP Kinase Signaling System
Chromosome Aberrations
1 Citation (Scopus)

Salt-sensitive transcriptome of isolated kidney distal tubule cells

Swanson, E. A., Nelson, J. W., Jeng, S., Erspamer, K. J., Yang, C-L., McWeeney, S. & Ellison, D., Apr 1 2019, In : Physiological genomics. 51, 4, p. 125-135 11 p.

Research output: Contribution to journalArticle

Distal Kidney Tubule
Aldosterone
Transcriptome
Salts
Diet
10 Citations (Scopus)

The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A., Druker, B., Chang, B., McWeeney, S. & Tyner, J., Jul 1 2019, In : Cancer discovery. 9, 7, p. 910-925 16 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Gene Silencing
Drug Combinations
Drug Resistance
1 Citation (Scopus)

Visualization of drug target interactions in the contexts of pathways and networks with reactomefiviz

Blucher, A. S., McWeeney, S., Stein, L. & Wu, G., Jan 1 2019, In : F1000Research. 8, 908.

Research output: Contribution to journalReview article

Open Access
Drug Interactions
Visualization
Pharmaceutical Preparations
Research Personnel
Precision Medicine

What do functional genomics tell us about pathogenesis of AML?

Tyner, J. W., Bottomly, D., Wilmot, B. & McWeeney, S., Jan 1 2019, (Accepted/In press) In : Best Practice and Research: Clinical Haematology. 101101.

Research output: Contribution to journalReview article

Genomics
Acute Myeloid Leukemia
Tumors
Molecular Biology
Pharmaceutical Preparations
2018
2 Citations (Scopus)

A single-cell approach to the elusive latent human cytomegalovirus transcriptome

Goodrum, F. & McWeeney, S., May 1 2018, In : mBio. 9, 3, e01001-18.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Cytomegalovirus
Transcriptome
Single-Cell Analysis
Gene Expression
9 Citations (Scopus)
Microbiota
Biomass
Urinary Tract
Vagina
Urinary Tract Infections
2 Citations (Scopus)

Cross-species molecular dissection across alcohol behavioral domains

Farris, S. P., Riley, B. P., Williams, R. W., Mulligan, M. K., Miles, M. F., Lopez, M. F., Hitzemann, R., Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Mayfield, R. D., Nov 1 2018, In : Alcohol. 72, p. 19-31 13 p.

Research output: Contribution to journalReview article

Dissection
alcohol
Alcohols
Alcoholism
Phenotype
64 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks
3 Citations (Scopus)

Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs

Iancu, O., Colville, A. M., Wilmot, B., Searles, R., Darakjian, P., Zheng, C., McWeeney, S., Kawane, S., Crabbe, J. J., Metten, P., Oberbeck, D. & Hitzemann, R., Aug 1 2018, In : Alcoholism: Clinical and Experimental Research. 42, 8, p. 1454-1465 12 p.

Research output: Contribution to journalArticle

Untranslated RNA
Drinking
Genes
Gene Expression
Transcriptome
1 Citation (Scopus)

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

Ouyang, X., Barling, A., Lesch, A., Tyner, J., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S., McWeeney, S. & Kulesz-Martin, M., Oct 3 2018, In : Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Small Interfering RNA
anaplastic lymphoma kinase
Carcinoma, squamous cell of head and neck
Neoplasms
28 Citations (Scopus)

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Sehrawat, A., Gao, L., Wang, Y., Bankhead, A., McWeeney, S., King, C. J., Schwartzman, J., Urrutia, J., Bisson, W. H., Coleman, D. J., Joshi, S. K., Kim, D. H., Sampson, D. A., Weinmann, S., Kallakury, B. V. S., Berry, D. L., Haque, R., Van Den Eeden, S. K., Sharma, S., Bearss, J. & 4 others, Beer, T. T., Thomas, G., Heiser, L. & Alumkal, J., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. E4179-E4188

Research output: Contribution to journalArticle

Gene Regulatory Networks
Neoplasm Genes
Lysine
Prostatic Neoplasms
Castration
2 Citations (Scopus)

Network-based predictors of progression in head and neck squamous cell carcinoma

Sanati, N., Iancu, O., Wu, G., Jacobs, J. E. & McWeeney, S., May 29 2018, In : Frontiers in Genetics. 9, MAY, 183.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Alcohol Drinking
Genes
Smoking
Gene Expression
3 Citations (Scopus)

Regional differences and similarities in the brain transcriptome for mice selected for ethanol preference from HS-CC founders

Colville, A. M., Iancu, O., Lockwood, D. R., Darakjian, P., McWeeney, S., Searles, R., Zheng, C. & Hitzemann, R., Aug 28 2018, In : Frontiers in Genetics. 9, AUG, 300.

Research output: Contribution to journalArticle

Transcriptome
Ethanol
Brain
Genes
Gene Regulatory Networks
1 Citation (Scopus)

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Leukemia
Acute Myeloid Leukemia
Myeloid Cells
Mitogen-Activated Protein Kinases
6 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
14 Citations (Scopus)
Endophenotypes
Attention Deficit Disorder with Hyperactivity
Short-Term Memory
Arousal
Structural Models
2017
2 Citations (Scopus)

Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)

Hitzemann, R., Oberbeck, D., Iancu, O., Darakjian, P., McWeeney, S., Spence, S., Schlumbohm, J., Metten, P. & Crabbe, J. J., May 1 2017, In : Alcohol. 60

Research output: Contribution to journalArticle

Transcriptome
Drinking
Animals
Ethanol
animal
36 Citations (Scopus)

A microRNA screen identifies the Wnt signaling pathway as a regulator of the interferon response during flavivirus infection

Smith, J. L., Jeng, S., McWeeney, S. & Hirsch, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02388-16.

Research output: Contribution to journalArticle

Flavivirus Infections
Flavivirus
Wnt Signaling Pathway
interferons
MicroRNAs
9 Citations (Scopus)

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

Zhang, H., Reister Schultz, A., Luty, S., Rofelty, A., Su, Y., Means, S., Bottomly, D., Wilmot, B., McWeeney, S. & Tyner, J., Dec 1 2017, In : Leukemia. 31, 12, p. 2752-2760 9 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
High-Throughput Nucleotide Sequencing
Ubiquitination
Leukemia
13 Citations (Scopus)

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

Lewinsohn, D., Swarbrick, G. M., Park, B., Cansler, M. E., Null, M. D., Toren, K. G., Baseke, J., Zalwango, S., Mayanja-Kizza, H., Malone, L. L., Nyendak, M., Wu, G., Guinn, K., McWeeney, S., Mori, M. T., Chervenak, K. A., Sherman, D. R., Boom, W. H. & Lewinsohn, D., Dec 1 2017, In : npj Vaccines. 2, 1, 8.

Research output: Contribution to journalArticle

CD8 Antigens
Immunodominant Epitopes
Mycobacterium tuberculosis
Tuberculosis
Tuberculosis Vaccines
12 Citations (Scopus)

Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice

Colville, A. M., Iancu, O., Oberbeck, D. L., Darakjian, P., Zheng, C., Walter, N. A. R., Harrington, C. C., Searles, R., McWeeney, S. & Hitzemann, R., 2017, (Accepted/In press) In : Genes, Brain and Behavior.

Research output: Contribution to journalArticle

Nucleus Accumbens
Ethanol
Gene Expression
Gene Regulatory Networks
Long Noncoding RNA
10 Citations (Scopus)

Evidence-Based Precision Oncology with the Cancer Targetome

Blucher, A. S., Choonoo, G., Kulesz-Martin, M., Wu, G. & McWeeney, S., 2017, (Accepted/In press) In : Trends in Pharmacological Sciences.

Research output: Contribution to journalArticle

Oncology
Drug Interactions
Pharmaceutical Preparations
Neoplasms
Research Personnel
12 Citations (Scopus)

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross

Graham, J. B., Swarts, J. L., Mooney, M., Choonoo, G., Jeng, S., Miller, D. R., Ferris, M. T., McWeeney, S. & Lund, J. M., Nov 21 2017, In : Cell Reports. 21, 8, p. 2313-2325 13 p.

Research output: Contribution to journalArticle

T-cells
Quantitative Trait Loci
Inbred Strains Mice
Immunology
Allergy and Immunology
5 Citations (Scopus)

Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics

Nielson, C., Wiedrick, J., Shen, J., Jacobs, J., Baker, E. S., Baraff, A., Piehowski, P., Lee, C., Baratt, A., Petyuk, V., McWeeney, S., Lim, J. Y., Bauer, D. C., Lane, N. E., Cawthon, P. M., Smith, R. D., Lapidus, J. & Orwoll, E., 2017, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Pelvic Bones
Proteomics
Bone Density
Hip Fractures
Serum
40 Citations (Scopus)

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

Interleukin-1
Acute Myeloid Leukemia
Disease Progression
Screening
Interleukin-1 Receptors
5 Citations (Scopus)

Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia

Lamble, A. J., Dietz, M., Laderas, T., McWeeney, S. & Lind, E., Jan 1 2017, (Accepted/In press) In : Journal of Immunological Methods.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mass Spectrometry
Flow Cytometry
Immune Evasion
Neoplasms
2 Citations (Scopus)

Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species

Davis, L., Jeng, S., Svalina, M. N., Huang, E., Pittsenbarger, J., Cantor, E. L., Berlow, N., Seguin, B., Mansoor, A., McWeeney, S. & Keller, C., 2017, In : Oncotarget. 8, 44, p. 76241-76256 16 p.

Research output: Contribution to journalArticle

Osteosarcoma
Neoplasms
Phosphotransferases
Melanoma-Specific Antigens
CC Chemokines
5 Citations (Scopus)

NFAT5 and SLC4A10 loci associate with plasma osmolality

Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P. & 86 others, Cucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C. M., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E. S., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D. M., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

Osmolar Concentration
Meta-Analysis
Water
Sodium
Hypernatremia
18 Citations (Scopus)

Oas1b-dependent immune transcriptional profiles of west nile virus infection in the collaborative cross

Green, R., Wilkins, C., Thomas, S., Sekine, A., Hendrick, D. M., Voss, K., Ireton, R. C., Mooney, M., Go, J. T., Choonoo, G., Jeng, S., de Villena, F. P. M., Ferris, M. T., McWeeney, S. & Gale, M., Jun 1 2017, In : G3: Genes, Genomes, Genetics. 7, 6, p. 1665-1682 18 p.

Research output: Contribution to journalArticle

West Nile virus
Flavivirus Infections
Virus Diseases
Ligases
Spleen
11 Citations (Scopus)

On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome

Iancu, O., Colville, A., Walter, N. A. R., Darakjian, P., Oberbeck, D. L., Daunais, J. B., Zheng, C., Searles, R., McWeeney, S., Grant, K. K. & Hitzemann, R., 2017, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

Macaca mulatta
Transcriptome
Self Administration
Ethanol
Brain
3 Citations (Scopus)

Recurrent cyclin D2 mutations in myeloid neoplasms

Khanna, V., Eide, C. A., Tognon, C. E., Maxson, J., Wilmot, B., Bottomly, D., McWeeney, S., Edwards, V. D. K., Druker, B. & Tyner, J., Sep 1 2017, In : Leukemia. 31, 9, p. 2005-2008 4 p.

Research output: Contribution to journalLetter

12 Citations (Scopus)

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation- differentiation balance in the developing brain

Monaghan, C. E., Nechiporuk, T., Jeng, S., McWeeney, S., Wang, J., Rosenfeld, M. G. & Mandel, G., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. E406-E415

Research output: Contribution to journalArticle

Co-Repressor Proteins
Insulinoma
Brain
Transcription Factors
Neurons
6 Citations (Scopus)

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Zhang, H., Means, S., Schultz, A. R., Watanabe-Smith, K., Medeiros, B. C., Bottomly, D., Wilmot, B., McWeeney, S., Kükenshöner, T., Hantschel, O. & Tyner, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4258-4267 10 p.

Research output: Contribution to journalArticle

Cysteine
Mutation
Leukemia, Neutrophilic, Chronic
Leukemia
Granulocyte Colony-Stimulating Factor Receptors
2016
21 Citations (Scopus)

A Mouse Model of Chronic West Nile Virus Disease

Graham, J. B., Swarts, J. L., Wilkins, C., Thomas, S., Green, R., Sekine, A., Voss, K. M., Ireton, R. C., Mooney, M., Choonoo, G., Miller, D. R., Treuting, P. M., Pardo Manuel de Villena, F., Ferris, M. T., McWeeney, S., Gale, M. & Lund, J. M., Nov 1 2016, In : PLoS Pathogens. 12, 11, e1005996.

Research output: Contribution to journalArticle

West Nile virus
Virus Diseases
Infection
Inbred Strains Mice
Regulatory T-Lymphocytes
10 Citations (Scopus)

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Protein Phosphatase 2
Cell Line
Phosphotransferases
1 Citation (Scopus)

Cover Image, Volume 171B, Number 6, September 2016

IMAGE2 Consortium & German ADHD GWAS Group, Sep 1 2016, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 171, 6, p. 1 1 p.

Research output: Contribution to journalComment/debate

17 Citations (Scopus)

Diversity outbred mice at 21: Maintaining allelic variation in the face of selection

Chesler, E. J., Gatti, D. M., Morgan, A. P., Strobel, M., Trepanier, L., Oberbeck, D., McWeeney, S., Hitzemann, R., Ferris, M., McMullan, R., Clayshultle, A., Bell, T. A., de Villena, F. P. M. & Churchill, G. A., 2016, In : G3: Genes, Genomes, Genetics. 6, 12, p. 3893-3902 10 p.

Research output: Contribution to journalArticle

Alleles
Gene Frequency
Chromosomes, Human, Pair 2
Population
Genome
66 Citations (Scopus)

Does the urinary microbiome play a role in urgency urinary incontinence and its severity?

Karstens, L., Asquith, M., Davin, S., Stauffer, P., Fair, D., Gregory, W. T., Rowsenbaum, J. T., McWeeney, S. & Nardos, R., Jul 27 2016, In : Frontiers in cellular and infection microbiology. 6, JUL, 78.

Research output: Contribution to journalArticle

Microbiota
Urinary Incontinence
Bacteria
Urinary Tract
Urinary Bladder
6 Citations (Scopus)

HitWalker2: Visual analytics for precision medicine and beyond

Bottomly, D., McWeeney, S. & Wilmot, B., Apr 15 2016, In : Bioinformatics. 32, 8, p. 1253-1255 3 p.

Research output: Contribution to journalArticle

Visual Analytics
Precision Medicine
Prioritization
Bioelectric potentials
Medicine
15 Citations (Scopus)

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. & Tyner, J., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Leukemia
Phosphotransferases
Mutation
Leukemia, Myelomonocytic, Chronic
25 Citations (Scopus)

IL-10 and integrin signaling pathways are associated with head and neck cancer progression

Bornstein, S., Schmidt, M., Choonoo, G., Levin, T., Gray, J., Thomas, C., Wong, M. & McWeeney, S., Jan 8 2016, In : BMC Genomics. 17, 1, 38.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Integrins
Interleukin-10
Genes
Neoplasms
19 Citations (Scopus)

Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach

Mooney, M., McWeeney, S., Faraone, S., Hinney, A., Hebebrand, J., Nigg, J. T. & Wilmot, B., 2016, (Accepted/In press) In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Genome-Wide Association Study
Genes
Fibroblast Growth Factor Receptors
Potassium Channels
6 Citations (Scopus)

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus

McDermott, J. E., Mitchell, H. D., Gralinski, L. E., Eisfeld, A. J., Josset, L., Bankhead, A., Neumann, G., Tilton, S. C., Schäfer, A., Li, C., Fan, S., McWeeney, S., Baric, R. S., Katze, M. G. & Waters, K. M., Sep 23 2016, In : BMC Systems Biology. 10, 1, 93.

Research output: Contribution to journalArticle

SARS Virus
Severe Acute Respiratory Syndrome
Enzyme inhibition
Tumor Necrosis Factor
Protein Phosphatase 1