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2011

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A. S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C. A., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

69 Scopus citations

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

Moran, A. E., Holzapfel, K. L., Xing, Y., Cunningham, N. R., Maltzman, J. S., Punt, J. & Hogquist, K. A., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Open Access
488 Scopus citations

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

Barbone, D., Ryan, J. A., Kolhatkar, N., Chacko, A. D., Jablons, D. M., Sugarbaker, D. J., Bueno, R., Letai, A. G., Coussens, L. M., Fennell, D. A. & Broaddus, V. C., Jun 1 2011, In : Cell Death and Disease. 2, 6, e174.

Research output: Contribution to journalArticle

31 Scopus citations

Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor

Masset, A., Maillard, C., Sounni, N. E., Jacobs, N., Bruyére, F., Delvenne, P., Tacke, M., Reinheckel, T., Foidart, J. M., Coussens, L. M. & Noaël, A., Jan 15 2011, In : International Journal of Cancer. 128, 2, p. 283-293 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas

Dalgin, G., Ward, A. B., Hao, L. T., Beattie, C. E., Nechiporuk, A. & Prince, V. E., Nov 1 2011, In : Development. 138, 21, p. 4597-4608 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2010

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling

Sherman, M. H., Kuraishy, A. I., Deshpande, C., Hong, J. S., Cacalano, N. A., Gatti, R. A., Manis, J. P., Damore, M. A., Pellegrini, M. & Teitell, M. A., Sep 1 2010, In : Molecular Cell. 39, 6, p. 873-885 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species

O'Brien, J., Lyons, T., Monks, J., Lucia, M. S., Wilson, R. S., Hines, L., Man, Y. G., Borges, V. & Schedin, P., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1241-1255 15 p.

Research output: Contribution to journalArticle

132 Scopus citations

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

Deng, L., Zhou, J. F., Sellers, R. S., Li, J. F., Nguyen, A. V., Wang, Y., Orlofsky, A., Liu, Q., Hume, D. A., Pollard, J. W., Augenlicht, L. & Lin, E. Y., Feb 2010, In : American Journal of Pathology. 176, 2, p. 952-967 16 p.

Research output: Contribution to journalArticle

122 Scopus citations

A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats

MacLean, P. S., Giles, E. D., Johnson, G. C., McDaniel, S. M., Fleming-Elder, B. K., Gilman, K. A., Andrianakos, A. G., Jackman, M. R., Shroyer, K. R. & Schedin, P. J., Apr 1 2010, In : Obesity. 18, 4, p. 696-703 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Park, J. J., Omiya, R., Matsumura, Y., Sakoda, Y., Kuramasu, A., Augustine, M. M., Yao, S., Tsushima, F., Narazaki, H., Anand, S., Liu, Y., Strome, S. E., Chen, L. & Tamada, K., Aug 26 2010, In : Blood. 116, 8, p. 1291-1298 8 p.

Research output: Contribution to journalArticle

200 Scopus citations

Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

Poczobutt, J. M., Tentler, J., Lu, X., Schedin, P. J. & Gutierrez-Hartmann, A., Jul 16 2010, In : BMC cancer. 10, 373.

Research output: Contribution to journalArticle

11 Scopus citations

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

Dennemärker, J., Lohmüller, T., Mayerle, J., Tacke, M., Lerch, M. M., Coussens, L. M., Peters, C. & Reinheckel, T., Mar 1 2010, In : Oncogene. 29, 11, p. 1611-1621 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF

Murphy, E. A., Shields, D. J., Stoletov, K., Dneprovskaia, E., McElroy, M., Greenberg, J. I., Lindquist, J., Acevedo, L. M., Anand, S., Majeti, B. K., Tsigelny, I., Saldanha, A., Walsh, B., Hoffman, R. M., Bouvet, M., Klemke, R. L., Vogt, P. K., Arnold, L., Wrasidlo, W. & Cheresh, D. A., Mar 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4299-4304 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Disruption of the Podosome Adaptor Protein TKS4 (SH3PXD2B) Causes the Skeletal Dysplasia, Eye, and Cardiac Abnormalities of Frank-Ter Haar Syndrome

Iqbal, Z., Cejudo-Martin, P., de Brouwer, A., van der Zwaag, B., Ruiz-Lozano, P., Scimia, M. C., Lindsey, J. D., Weinreb, R., Albrecht, B., Megarbane, A., Alanay, Y., Ben-Neriah, Z., Amenduni, M., Artuso, R., Veltman, J. A., van Beusekom, E., Oudakker, A., Millán, J. L., Hennekam, R., Hamel, B. & 2 others, Courtneidge, S. A. & van Bokhoven, H., Feb 12 2010, In : American Journal of Human Genetics. 86, 2, p. 254-261 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats

Giles, E. D., Jackman, M. R., Johnson, G. C., Schedin, P. J., Houser, J. L. & MacLean, P. S., Dec 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 299, 6, p. R1634-R1642

Research output: Contribution to journalArticle

25 Scopus citations

EMX2 is epigenetically silenced and suppresses growth in human lung cancer

Okamoto, J., Hirata, T., Chen, Z., Zhou, H. M., Mikami, I., Li, H., Beltran, A., Johansson, M., Coussens, L. M., Clement, G., Shi, Y., Zhang, F., Koizumi, K., Shimizu, K., Jablons, D. & He, B., Nov 4 2010, In : Oncogene. 29, 44, p. 5969-5975 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Enhancing the delivery of anti retroviral drug "saquinavir" across the blood brain barrier using nanoparticles

Mahajan, S. D., Roy, I., Xu, G. X., Yong, K. T., Ding, H., Aalinkeel, R., Reynolds, J. L., Sykes, D. E., Nair, B. B., Lin, E. Y., Prasad, P. N. & Schwartz, S. A., Jul 23 2010, In : Current HIV Research. 8, 5, p. 396-404 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

Andreu, P., Johansson, M., Affara, N. I., Pucci, F., Tan, T., Junankar, S., Korets, L., Lam, J., Tawfik, D., DeNardo, D. G., Naldini, L., de Visser, K. E., De Palma, M. & Coussens, L. M., Feb 17 2010, In : Cancer Cell. 17, 2, p. 121-134 14 p.

Research output: Contribution to journalArticle

322 Scopus citations

Gelatin microspheres crosslinked with genipin for local delivery of growth factors.

Solorio, L., Zwolinski, C., Lund, A. W., Farrell, M. J. & Stegemann, J. P., Oct 2010, In : Journal of tissue engineering and regenerative medicine. 4, 7, p. 514-523 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Generation of mice with a conditional allele for Ift172

Howard, P. W., Howard, T. L. & Maurer, R. A., Jan 1 2010, In : Transgenic Research. 19, 1, p. 121-126 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Gao, J., Chen, J., De Domenico, I., Koeller, D. M., Harding, C. O., Fleming, R. E., Koeberl, D. D. & Enns, C. A., Apr 22 2010, In : Blood. 115, 16, p. 3374-3381 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Lymphocytes in cancer development: Polarization towards pro-tumor immunity

Ruffell, B., DeNardo, D. G., Affara, N. I. & Coussens, L. M., Feb 1 2010, In : Cytokine and Growth Factor Reviews. 21, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

Macrophage expression of hypoxia-inducible factor-1α suppresses T-cell function and promotes tumor progression

Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W. & Johnson, R. S., Oct 1 2010, In : Cancer Research. 70, 19, p. 7465-7475 11 p.

Research output: Contribution to journalArticle

294 Scopus citations
47 Scopus citations

Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells

Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J. & Heller, S., May 1 2010, In : Cell. 141, 4, p. 704-716 13 p.

Research output: Contribution to journalArticle

202 Scopus citations

MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

Anand, S., Majeti, B. K., Acevedo, L. M., Murphy, E. A., Mukthavaram, R., Scheppke, L., Huang, M., Shields, D. J., Lindquist, J. N., Lapinski, P. E., King, P. D., Weis, S. M. & Cheresh, D. A., Aug 1 2010, In : Nature medicine. 16, 8, p. 909-914 6 p.

Research output: Contribution to journalArticle

377 Scopus citations

MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

Quintavalle, M., Elia, L., Condorelli, G. & Courtneidge, S. A., Apr 5 2010, In : Journal of Cell Biology. 189, 1, p. 13-22 10 p.

Research output: Contribution to journalArticle

152 Scopus citations

Quantification of three-dimensional cell-mediated collagen remodeling using graph theory

Bilgin, C. C., Lund, A. W., Can, A., Plopper, G. E. & Yener, B., Nov 1 2010, In : PloS one. 5, 9, p. 1-12 12 p., e12783.

Research output: Contribution to journalArticle

11 Scopus citations

Quantification of vestibular-induced eye movements in zebrafish larvae.

Mo, W., Chen, F., Nechiporuk, A. & Nicolson, T., 2010, In : BMC neuroscience. 11, 1 p.

Research output: Contribution to journalArticle

41 Scopus citations

Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function

Taraseviciute, A., Vincent, B. T., Schedin, P. & Jones, P. L., Feb 2010, In : American Journal of Pathology. 176, 2, p. 827-838 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response

Ursini-Siegel, J., Cory, S., Zuo, D., Hardy, W. R., Rexhepaj, E., Lam, S., Schade, B., Jirstrom, K., Bjur, E., Piccirillo, C. A., DeNardo, D., Coussens, L. M., Brennan, D. J., Gallagher, W. M., Park, M., Pawson, T., Hallett, M. & Muller, W. J., Oct 15 2010, In : Cancer Research. 70, 20, p. 7776-7787 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain

Sopory, S., Kwon, S., Wehrli, M. & Christian, J. L., Oct 2010, In : Developmental Biology. 346, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134

Howard, P. W., Jue, S. F., Ransom, D. G. & Maurer, R. A., Jul 1 2010, In : Biochemical Journal. 429, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ricin toxin activates the NALP3 inflammasome

Lindauer, M., Wong, J. & Magun, B., Jun 1 2010, In : Toxins. 2, 6, p. 1500-1514 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A. S. & Enns, C. A., Jan 1 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Stromal regulation of vessel stability by MMP14 and TGFβ

Sounni, N. E., Dehne, K., Van Kempen, L., Egeblad, M., Affara, N. I., Cuevas, I., Wiesen, J., Junankar, S., Korets, L., Lee, J., Shen, J., Morrison, C. J., Overall, C. M., Krane, S. M., Werb, Z., Boudreau, N. & Coussens, L. M., May 1 2010, In : DMM Disease Models and Mechanisms. 3, 5-6, p. 317-332 16 p.

Research output: Contribution to journalArticle

55 Scopus citations

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A. S., Gao, J., Koeberl, D. D. & Enns, C. A., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Transcription intermediary factor 1γ decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1

Howard, P. W., Ransom, D. G. & Maurer, R. A., Jun 4 2010, In : Biochemical and Biophysical Research Communications. 396, 3, p. 674-678 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells

Sauter, K. A. D., Magun, E. A., Iordanov, M. S. & Magun, B. E., Aug 1 2010, In : Cancer Biology and Therapy. 10, 3, p. 258-266 9 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin

Zhao, N., Gao, J., Enns, C. A. & Knutson, M. D., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32141-32150 10 p.

Research output: Contribution to journalArticle

103 Scopus citations
2009

An in-solution ultrasonication-assisted digestion method for improved extracellular matrix proteome coverage

Hansen, K. C., Kiemele, L., Maller, O., O'Brien, J., Shankar, A., Fornetti, J. & Schedin, P., Dec 8 2009, In : Molecular and Cellular Proteomics. 8, 7, p. 1648-1657 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

B7-H4-deficient mice display augmented neutrophil-mediated innate immunity

Zhu, G., Augustine, M. M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A. C., Huang, J., Xu, H., Flies, A. S., Flies, S. J., Tamada, K., Colonna, M., Van Deursen, J. M. A. & Chen, L., Feb 19 2009, In : Blood. 113, 8, p. 1759-1767 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

DeNardo, D. G., Barreto, J. B., Andreu, P., Vasquez, L., Tawfik, D., Kolhatkar, N. & Coussens, L. M., Aug 4 2009, In : Cancer Cell. 16, 2, p. 91-102 12 p.

Research output: Contribution to journalArticle

752 Scopus citations

Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation

Oshimori, N., Li, X., Ohsugi, M. & Yamamoto, T., Jul 22 2009, In : EMBO Journal. 28, 14, p. 2066-2076 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
Open Access
41 Scopus citations

Development of an optimized activatable MMP-14 targeted SPECT imaging probe

Watkins, G. A., Jones, E. F., Scott Shell, M., VanBrocklin, H. F., Pan, M. H., Hanrahan, S. M., Feng, J. J., He, J., Sounni, N. E., Dill, K. A., Contag, C. H., Coussens, L. M. & Franc, B. L., Jan 15 2009, In : Bioorganic and Medicinal Chemistry. 17, 2, p. 653-659 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

Chen, S. S., Raval, A., Johnson, A. J., Hertlein, E., Liua, T. H., Jin, V. X., Sherman, M. H., Liu, S. J., Dawson, D. W., Williams, K. E., Lanasa, M., Liyanarachchi, S., Lin, T. S., Marcucci, G., Pekarsky, Y., Davuluri, R., Croce, C. M., Guttridge, D. C., Teitell, M. A., Byrd, J. C. & 1 others, Plass, C., Aug 11 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 32, p. 13433-13438 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress

Balatoni, C. E., Dawson, D. W., Suh, J., Sherman, M. H., Sanders, G., Hong, J. S., Frank, M. J., Malone, C. S., Said, J. W. & Teitell, M. A., Jan 1 2009, In : American Journal of Pathology. 175, 4, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1

Howard, P. W., Jue, S. F. & Maurer, R. A., Oct 14 2009, In : Molecular Endocrinology. 23, 10, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A. S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C. A., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

59 Scopus citations