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2012

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration

Chen, T., Heller, E., Beronja, S., Oshimori, N., Stokes, N. & Fuchs, E., May 3 2012, In : Nature. 485, 7396, p. 104-108 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Antigen-independent differentiation and maintenance of effector-like resident memory T Cells in tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V. & Masopust, D., May 15 2012, In : Journal of Immunology. 188, 10, p. 4866-4875 10 p.

Research output: Contribution to journalArticle

282 Scopus citations

Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma

Munson, J. M., Fried, L., Rowson, S. A., Bonner, M. Y., Karumbaiah, L., Diaz, B., Courtneidge, S. A., Knaus, U. G., Brat, D. J., Arbiser, J. L. & Bellamkonda, R. V., Mar 28 2012, In : Science translational medicine. 4, 127, 127ra36.

Research output: Contribution to journalArticle

65 Scopus citations

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation

Huang, M., Anand, S., Murphy, E. A., Desgrosellier, J. S., Stupack, D. G., Shattil, S. J., Schlaepfer, D. D. & Cheresh, D. A., May 31 2012, In : Oncogene. 31, 22, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1

Lau, S. K. M., Shields, D. J., Murphy, E. A., Desgrosellier, J. S., Anand, S., Huang, M., Kato, S., Lim, S. T., Weis, S. M., Stupack, D. G., Schlaepfer, D. D. & Cheresh, D. A., May 7 2012, In : PloS one. 7, 5, e36753.

Research output: Contribution to journalArticle

29 Scopus citations

Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory

Park, J. J., Anand, S., Zhao, Y., Matsumura, Y., Sakoda, Y., Kuramasu, A., Strome, S. E., Chen, L. & Tamada, K., Feb 1 2012, In : Cancer Immunology, Immunotherapy. 61, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Fer kinase regulates cell migration through α-dystroglycan glycosylation

Yoneyama, T., Angata, K., Bao, X., Courtneidge, S., Chanda, S. K. & Fukuda, M., Mar 1 2012, In : Molecular biology of the cell. 23, 5, p. 771-780 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
46 Scopus citations

Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.

McCarroll, M. N., Lewis, Z. R., Culbertson, M. D., Martin, B. L., Kimelman, D. & Nechiporuk, A. V., Aug 2012, In : Development (Cambridge, England). 139, 15, p. 2740-2750 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Bonde, A. K., Tischler, V., Kumar, S., Soltermann, A. & Schwendener, R. A., Jan 24 2012, In : BMC cancer. 12, 35.

Research output: Contribution to journalArticle

129 Scopus citations

Leukocyte composition of human breast cancer

Ruffell, B., Au, A., Rugo, H. S., Esserman, L. J., Hwang, E. S. & Coussens, L. M., Feb 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 8, p. 2796-2801 6 p.

Research output: Contribution to journalArticle

225 Scopus citations

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution

O'Brien, J., Martinson, H., Durand-Rougely, C. & Schedin, P., Jan 15 2012, In : Development. 139, 2, p. 269-275 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Metformin-mediated bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling

Subramaniam, N., Sherman, M. H., Rao, R., Wilson, C., Coulter, S., Atkins, A. R., Evans, R. M., Liddle, C. & Downes, M., Apr 2012, In : Cancer Prevention Research. 5, 4, p. 553-561 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C. A., Ahmed, R. & Zhang, A. S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints

Tsang, Y. H., Han, X., Man, W. Y., Lee, N. & Poon, R. Y. C., Nov 26 2012, In : PloS one. 7, 11, e49943.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer

Giles, E. D., Wellberg, E. A., Astling, D. P., Anderson, S. M., Thor, A. D., Jindal, S., Tan, A. C., Schedin, P. S. & MacLean, P. S., Dec 15 2012, In : Cancer Research. 72, 24, p. 6490-6501 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation

Oshimori, N. & Fuchs, E., Jan 6 2012, In : Cell Stem Cell. 10, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

199 Scopus citations

Protective role of cathepsin L in mouse skin carcinogenesis

Benavides, F., Perez, C., Blando, J., Contreras, O., Shen, J., Coussens, L. M., Fischer, S. M., Kusewitt, D. F., Digiovanni, J. & Conti, C. J., Apr 1 2012, In : Molecular Carcinogenesis. 51, 4, p. 352-361 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin

Kassa, R., Monterroso, V., Wentzell, J., Ramos, A. L., Couchi, E., Lecomte, M. C., Iordanov, M., Kretzschmar, D., Nicolas, G. & Tshala-Katumbay, D., Jul 1 2012, In : Journal of Molecular Neuroscience. 47, 3, p. 631-638 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Q&A: Lisa Coussens on immune reprogramming.

Coussens, L., Jun 1 2012, In : Cancer discovery. 2, 6, 1 p.

Research output: Contribution to journalArticle

Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing

Obholzer, N., Swinburne, I. A., Schwab, E., Nechiporuk, A. V., Nicolson, T. & Megason, S. G., Nov 15 2012, In : Development (Cambridge). 139, 22, p. 4280-4290 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis

OBrien, J. H., Vanderlinden, L. A., Schedin, P. J. & Hansen, K. C., Oct 5 2012, In : Journal of Proteome Research. 11, 10, p. 4894-4905 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib.

Stone, S. M., Thorpe, C. M., Ahluwalia, A., Rogers, A. B., Obata, F., Vozenilek, A., Kolling, G. L., Kane, A. V., Magun, B. E. & Jandhyala, D. M., 2012, In : Frontiers in Cellular and Infection Microbiology. 2, 1 p.

Research output: Contribution to journalArticle

20 Scopus citations

Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome

Vyleta, M. L., Wong, J. & Magun, B. E., May 14 2012, In : PloS one. 7, 5, e36044.

Research output: Contribution to journalArticle

27 Scopus citations

Tumor microenvironment complexity: Emerging roles in cancer therapy

Swartz, M. A., Iida, N., Roberts, E. W., Sangaletti, S., Wong, M. H., Yull, F. E., Coussens, L. M. & DeClerck, Y. A., May 15 2012, In : Cancer Research. 72, 10, p. 2473-2480 8 p.

Research output: Contribution to journalArticle

293 Scopus citations

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Lund, A. W., Duraes, F. V., Hirosue, S., Raghavan, V. R., Nembrini, C., Thomas, S. N., Issa, A., Hugues, S. & Swartz, M. A., Mar 29 2012, In : Cell Reports. 1, 3, p. 191-199 9 p.

Research output: Contribution to journalArticle

159 Scopus citations
2011

A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion

Quintavalle, M., Elia, L., Price, J. H., Heynen-Genel, S. & Courtneidge, S. A., Jul 26 2011, In : Science signaling. 4, 183, ra49.

Research output: Contribution to journalArticle

70 Scopus citations

A MEK-independent role for CRAF in mitosis and tumor progression

Mielgo, A., Seguin, L., Huang, M., Camargo, M. F., Anand, S., Franovic, A., Weis, S. M., Advani, S. J., Murphy, E. A. & Cheresh, D. A., Dec 1 2011, In : Nature medicine. 17, 12, p. 1641-1645 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
2 Scopus citations

A Src-Tks5 pathway is required for neural crest cell migration during embryonic development

Murphy, D. A., Diaz, B., Bromann, P. A., Tsai, J. H., Kawakami, Y., Maurer, J., Stewart, R. A., Izpisúa-Belmonte, J. C. & Courtneidge, S. A., 2011, In : PloS one. 6, 7, e22499.

Research output: Contribution to journalArticle

59 Scopus citations

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug

Copenhaver, P. F., Anekonda, T. S., Musashe, D., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. L. & Quinn, J. F., Sep 1 2011, In : DMM Disease Models and Mechanisms. 4, 5, p. 634-648 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis

Schioppa, T., Moore, R., Thompson, R. G., Rosser, E. C., Kulbe, H., Nedospasov, S., Mauri, C., Coussens, L. M. & Balkwill, F. R., Jun 28 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. 10662-10667 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Chondrogenic and gliogenic subpopulations of neural crest play distinct roles during the assembly of epibranchial ganglia

Culbertson, M. D., Lewis, Z. R. & Nechiporuk, A. V., Sep 9 2011, In : PloS one. 6, 9, e24443.

Research output: Contribution to journalArticle

13 Scopus citations

Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages

Shim, Y. J., Kang, B. H., Jeon, H. S., Park, I. S., Lee, K. U., Lee, I. K., Park, G. H., Lee, K. M., Schedin, P. & Min, B. H., Oct 1 2011, In : Journal of Leukocyte Biology. 90, 4, p. 761-769 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

Sauter, K. A. D., Wood, L. J., Wong, J., Iordanov, M. & Magun, B. E., Jun 15 2011, In : Cancer Biology and Therapy. 11, 12, p. 1008-1016 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models

Cheong, J. H., Park, E. S., Liang, J., Dennison, J. B., Tsavachidou, D., Nguyen-Charles, C., Cheng, K. W., Hall, H., Zhang, D., Lu, Y., Ravoori, M., Kundra, V., Ajani, J., Lee, J. S., Hong, W. K. & Mills, G. B., Dec 2011, In : Molecular cancer therapeutics. 10, 12, p. 2350-2362 13 p.

Research output: Contribution to journalArticle

159 Scopus citations

Emerging Role of Micro-RNAs in the Regulation of Angiogenesis

Anand, S. & Cheresh, D. A., Dec 1 2011, In : Genes and Cancer. 2, 12, p. 1134-1138 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

Shin, K., Lee, J., Guo, N., Kim, J., Lim, A., Qu, L., Mysorekar, I. U. & Beachy, P. A., Apr 7 2011, In : Nature. 472, 7341, p. 110-116 7 p.

Research output: Contribution to journalArticle

255 Scopus citations

Herpesvirus entry mediator regulates hypoxiainducible factor-1α and erythropoiesis in mice

Sakoda, Y., Anand, S., Zhao, Y., Park, J. J., Liu, Y., Kuramasu, A., Van Rooijen, N., Chen, L., Strome, S. E., Hancock, W. W., Chen, L. & Tamada, K., Dec 1 2011, In : Journal of Clinical Investigation. 121, 12, p. 4810-4819 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Histamine restricts cancer: Nothing to sneeze at

Ruffell, B. & Coussens, L. M., Jan 1 2011, In : Nature medicine. 17, 1, p. 43-44 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

Immune microenvironments in solid tumors: New targets for therapy

Shiao, S. L., Preethi Ganesan, A., Rugo, H. S. & Coussens, L. M., Dec 15 2011, In : Genes and Development. 25, 24, p. 2559-2572 14 p.

Research output: Contribution to journalArticle

204 Scopus citations

Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium

McGraw, H. F., Drerup, C. M., Culbertson, M. D., Linbo, T., Raible, D. W. & Nechiporuk, A. V., Sep 15 2011, In : Development. 138, 18, p. 3921-3930 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy

DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., Rugo, H. S., Shelley Hwang, E., Jirström, K., West, B. L. & Coussens, L. M., Jun 2011, In : Cancer discovery. 1, 1, p. 54-67 14 p.

Research output: Contribution to journalArticle

925 Scopus citations

Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization

Erez, N. & Coussens, L. M., Jun 1 2011, In : International Journal of Cancer. 128, 11, p. 2536-2544 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Leukocytes in mammary development and cancer

Coussens, L. M. & Pollard, J. W., Mar 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 3, p. 1-22 22 p.

Research output: Contribution to journalArticle

98 Scopus citations
222 Scopus citations

MicroRNA-mediated regulation of the angiogenic switch

Anand, S. & Cheresh, D. A., May 1 2011, In : Current opinion in hematology. 18, 3, p. 171-176 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles

Daldrup-Link, H. E., Golovko, D., Ruffell, B., DeNardo, D. G., Castaneda, R., Ansari, C., Rao, J., Tikhomirov, G. A., Wendland, M. F., Corot, C. & Coussens, L. M., Sep 1 2011, In : Clinical Cancer Research. 17, 17, p. 5695-5704 10 p.

Research output: Contribution to journalArticle

171 Scopus citations

Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland

O'Brien, J., Hansen, K., Barkan, D., Green, J. & Schedin, P., Dec 6 2011, In : International Journal of Developmental Biology. 55, 7-9, p. 745-755 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer

Wang, D., Peregrina, K., Dhima, E., Lin, E. Y., Mariadason, J. M. & Augenlicht, L. H., Jun 21 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10272-10277 6 p.

Research output: Contribution to journalArticle

31 Scopus citations