Research Output 1969 2019

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2008
127 Citations (Scopus)

FGF-dependent mechanosensory organ patterning in zebrafish

Nechiporuk, A. & Raible, D. W., Jun 27 2008, In : Science. 320, 5884, p. 1774-1777 4 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Zebrafish
Rosette Formation
Periodicity
Morphogenesis
32 Citations (Scopus)

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A-S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Iron
Macrophages
Liver
Kupffer Cells
60 Citations (Scopus)

Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody

Sauter, K. A. D., Melton-Celsa, A. R., Larkin, K., Troxell, M., O'Brien, A. D. & Magun, B. E., Oct 2008, In : Infection and Immunity. 76, 10, p. 4469-4478 10 p.

Research output: Contribution to journalArticle

Shiga Toxin 2
Hemolytic-Uremic Syndrome
Endotoxins
Antibodies
Fibrin
33 Citations (Scopus)

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

Zhang, A-S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J. & Enns, C., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17494-17502 9 p.

Research output: Contribution to journalArticle

Cell membranes
Cell Membrane
Hepcidins
Endocytosis
Hepatocytes
10 Citations (Scopus)
Ephrins
Manduca
Glycosylphosphatidylinositols
Embryonic Development
Neurons
53 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 Cells

Gao, J., Zhao, N., Knutson, M. D. & Enns, C., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21462-21468 7 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Down-Regulation
Iron
Proteins
Transferrin
17 Citations (Scopus)

Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms

Zhang, A-S., Canonne-Hergaux, F., Gruenheid, S., Gros, P. & Ponka, P., Oct 2008, In : Experimental Hematology. 36, 10, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

Reticulocytes
Cricetulus
Ovary
Iron
Transferrin
44 Citations (Scopus)

Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1

McGraw, H. F., Nechiporuk, A. & Raible, D. W., Nov 19 2008, In : Journal of Neuroscience. 28, 47, p. 12558-12569 12 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Zebrafish
Neuroglia
Neural Crest
Green Fluorescent Proteins
2007
163 Citations (Scopus)

Direct interorganellar transfer of iron from endosome to mitochondrion

Sheftel, A. D., Zhang, A-S., Brown, C., Shirihai, O. S. & Ponka, P., Jul 1 2007, In : Blood. 110, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Mitochondria
Endosomes
Iron
Oxygen
Metals
8 Citations (Scopus)

Eph receptor expression defines midline boundaries for ephrin-positive migratory neurons in the enteric nervous system of Manduca sexta

Coate, T. M., Swanson, T. L., Proctor, T. M., Nighorn, A. J. & Copenhaver, P., May 10 2007, In : Journal of Comparative Neurology. 502, 2, p. 175-191 17 p.

Research output: Contribution to journalArticle

EphA1 Receptor
Ephrins
Enteric Nervous System
Manduca
Neurons
91 Citations (Scopus)

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A-S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Muscle
Skeletal Muscle
Cells
69 Citations (Scopus)

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions

Chen, J., Chloupková, M., Gao, J., Chapman-Arvedson, T. L. & Enns, C., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 36862-36870 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Cell Communication
Hepatocellular Carcinoma
HLA-B7 Antigen
25 Citations (Scopus)
Enteric Nervous System
Insects
Vertebrates
Neurons
Epithelial-Mesenchymal Transition
37 Citations (Scopus)

Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage

Wong, J., Korcheva, V., Jacoby, D. & Magun, B., May 2007, In : American Journal of Pathology. 170, 5, p. 1497-1510 14 p.

Research output: Contribution to journalArticle

Ricin
Kidney
Lung
Body Weight
RNA
33 Citations (Scopus)
Ricin
Proto-Oncogene Proteins c-akt
Heat-Shock Proteins
p38 Mitogen-Activated Protein Kinases
Lung
47 Citations (Scopus)

Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages

Korcheva, V., Wong, J., Lindauer, M., Jacoby, D., Iordanov, M. S. & Magun, B., Apr 2007, In : Molecular Immunology. 44, 10, p. 2761-2771 11 p.

Research output: Contribution to journalArticle

Ricin
Macrophages
Adult Respiratory Distress Syndrome
Cytokines
Lung
21 Citations (Scopus)

The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells

Chen, J. & Enns, C., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6201-6209 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Iron
Inborn Genetic Diseases
Iron Overload
69 Citations (Scopus)

Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway

Johnson, M. B., Chen, J., Murchison, N., Green, F. A. & Enns, C., Mar 2007, In : Molecular Biology of the Cell. 18, 3, p. 743-754 12 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Ligands
Endosomes
Iron
Mutation
40 Citations (Scopus)

Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein

Sheets, L., Ransom, D. G., Mellgren, E. M., Johnson, S. L. & Schnapp, B., Oct 23 2007, In : Current Biology. 17, 20, p. 1721-1734 14 p.

Research output: Contribution to journalArticle

Melanosomes
Dyneins
melanocytes
Myosin Type V
Zebrafish
2006
172 Citations (Scopus)

A change in the selective translocation of the kinesin-1 motor domain marks the initial specification of the axon

Jacobson, C., Schnapp, B. & Banker, G., Mar 16 2006, In : Neuron. 49, 6, p. 797-804 8 p.

Research output: Contribution to journalArticle

Kinesin
Axons
Neurites
Neurons
48 Citations (Scopus)

A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP

Munro, T. P., Kwon, S., Schnapp, B. & St Johnston, D., Feb 13 2006, In : Journal of Cell Biology. 172, 4, p. 577-588 12 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Protein Biosynthesis
Drosophila melanogaster
Protein Binding
Carrier Proteins
39 Citations (Scopus)

c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP

Wang, S. Y., Iordanov, M. & Zhang, Q., Nov 17 2006, In : Journal of Biological Chemistry. 281, 46, p. 34810-34815 6 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
JNK Mitogen-Activated Protein Kinases
Carrier Proteins
Apoptosis
Phosphorylation
23 Citations (Scopus)

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

Ryabinina, O. P., Subbian, E. & Iordanov, M. S., Jan 2 2006, In : BMC Cell Biology. 7

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Cadmium
Drosophila
Oxidative Stress
Phosphotransferases
38 Citations (Scopus)

Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: Implications for Dermatitis

Farley, S. M., Dotson, A. D., Purdy, D. E., Sundholm, A. J., Schneider, P., Magun, B. E. & Iordanov, M. S., Nov 15 2006, In : Journal of Investigative Dermatology. 126, 11, p. 2438-2451 14 p.

Research output: Contribution to journalArticle

Dermatitis
Fas Ligand Protein
Caspases
Keratinocytes
Apoptosis
50 Citations (Scopus)

Human cytomegalovirus attenuates interleukin-1β and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-κB activation

Jarvis, M. A., Borton, J. A., Keech, A. M., Wong, J., Britt, W. J., Magun, B. E. & Nelson, J., Jun 2006, In : Journal of Virology. 80, 11, p. 5588-5598 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
interleukin-1
Cytomegalovirus
Interleukin-1
tumor necrosis factor-alpha

Iron in mammals: Pathophysiological mechanisms of overload and deficiency in relation to disease

Johnson, M. B., Enns, C. & Zhang, A-S., 2006, In : Topics in Current Genetics. 14, p. 155-191 37 p.

Research output: Contribution to journalArticle

Mammals
Iron
Hemochromatosis
Protein Transport
Anemia
12 Citations (Scopus)

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis

Enns, C., 2006, In : Biological Research. 39, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

hemochromatosis
homeostasis
Homeostasis
Iron
iron
38 Citations (Scopus)

Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain

Sopory, S., Nelsen, S., Degnin, C., Wong, C. & Christian, J. L., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34021-34031 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Ligands
Protein Precursors
Proprotein Convertases
Bone Morphogenetic Protein 7
29 Citations (Scopus)

The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling

Zhang, A-S., Sheftel, A. D. & Ponka, P., May 2006, In : Experimental Hematology. 34, 5, p. 593-598 6 p.

Research output: Contribution to journalArticle

Transferrin
Anemia
Hemoglobins
Iron
Reticulocytes
2005
69 Citations (Scopus)
Ricin
Hemolytic-Uremic Syndrome
p38 Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
Interleukin-1
21 Citations (Scopus)

Cell death-induced activation of epidermal growth factor receptor in keratinocytes: Implications for restricting epidermal damage in dermatitis

Iordanov, M. S., Sundholm, A. J., Simpson, E., Hanifin, J., Ryabinina, O. P., Choi, R. J., Korcheva, V., Schneider, P. & Magun, B. E., Jul 2005, In : Journal of Investigative Dermatology. 125, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Dermatitis
Cell death
Keratinocytes
Epidermal Growth Factor Receptor
Cell Death
112 Citations (Scopus)

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A-S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

Iron
Kidney
GPI-Linked Proteins
Mutation
Hepcidins
8 Citations (Scopus)

Lipooligosaccharide-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells

Bonnah, R., Hoelter, J., Steeghs, L., Enns, C., So, M. & Muckenthaler, M. U., Jun 2005, In : Cellular Microbiology. 7, 6, p. 869-885 17 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Homeostasis
Epithelial Cells
Iron
Transferrin Receptors
11 Citations (Scopus)

Proprotein convertase genes in Xenopus development

Nelsen, S., Berg, L., Wong, C. & Christian, J. L., Jul 2005, In : Developmental Dynamics. 233, 3, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

Proprotein Convertases
Furin
Xenopus
Protein Isoforms
Genes
23 Citations (Scopus)

Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs)

Iordanov, M. S., Kirsch, J. D., Ryabinina, O. P., Wong, J., Spitz, P. N., Korcheva, V., Thorburn, A. & Magun, B. E., Jan 2005, In : Apoptosis. 10, 1, p. 167-176 10 p.

Research output: Contribution to journalArticle

Death Domain Receptor Signaling Adaptor Proteins
Double-Stranded RNA
Caspase 8
Chemical activation
Apoptosis
23 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Carlson, H., Zhang, A-S., Fleming, W. & Enns, C., Mar 15 2005, In : Blood. 105, 6, p. 2564-2570 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Transferrin
Proteins
Hemochromatosis
24 Citations (Scopus)

The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Goα in an identified population of migratory neurons

Swanson, T. L., Knittel, L. M., Coate, T. M., Farley, S. M., Snyder, M. A. & Copenhaver, P., Dec 1 2005, In : Developmental Biology. 288, 1, p. 160-178 19 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins
Amyloid beta-Protein Precursor
Insects
Neurons
39 Citations (Scopus)

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin

Giannetti, A. M., Halbrooks, P. J., Mason, A. B., Vogt, T. M., Enns, C. & Björkman, P. J., Nov 2005, In : Structure. 13, 11, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Carrier Proteins
Iron
Binding Sites
12 Citations (Scopus)
Transcription Factor Pit-1
Prolactin
Chromatin
Micrococcal Nuclease
5' Flanking Region
21 Citations (Scopus)

Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis

Iordanov, M. S., Ryabinina, O. P., Schneider, P. & Magun, B. E., Jan 2005, In : Apoptosis. 10, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Caspase 9
Caspase 8
RNA Viruses
Viruses
2004
46 Citations (Scopus)

Chronic Liver Disease in Murine Hereditary Tyrosinemia Type 1 Induces Resistance to Cell Death

Vogel, A., Van Den Berg, I. E. T., Al-Dhalimy, M., Groopman, J., Ou, C. N., Ryabinina, O., Iordanov, M. S., Finegold, M. & Grompe, M., Feb 2004, In : Hepatology. 39, 2, p. 433-443 11 p.

Research output: Contribution to journalArticle

Tyrosinemias
Liver Diseases
Chronic Disease
Cell Death
Homogentisic Acid
170 Citations (Scopus)

Diferric transferrin regulates transferrin receptor 2 protein stability

Johnson, M. B. & Enns, C., Dec 15 2004, In : Blood. 104, 13, p. 4287-4293 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Protein Stability
Proteins
Iron
Transferrin
23 Citations (Scopus)

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis

Bonnah, R., Muckenthaler, M. U., Carlson, H., Minana, B., Enns, C., Hentze, M. W. & So, M., May 2004, In : Cellular Microbiology. 6, 5, p. 473-484 12 p.

Research output: Contribution to journalArticle

Neisseria meningitidis
Transferrin Receptors
Iron
Genes
Epithelial Cells
40 Citations (Scopus)

Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells

Davies, P. & Enns, C., Jun 11 2004, In : Journal of Biological Chemistry. 279, 24, p. 25085-25092 8 p.

Research output: Contribution to journalArticle

HT29 Cells
Ferritins
Iron
Proteins
Transferrin Receptors
140 Citations (Scopus)

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A-S., Xiong, S., Tsukamoto, H. & Enns, C., Feb 15 2004, In : Blood. 103, 4, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Metabolism
Liver
Rats
Hepatocytes
Iron
2003
29 Citations (Scopus)

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P., Zhang, A-S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Endosomes
Transferrin
Iron
14 Citations (Scopus)

Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB

Song, S. B., Rhee, M., Roberson, M. S., Maurer, R. & Kim, K. E., Jan 31 2003, In : Molecular and Cellular Endocrinology. 199, 1-2, p. 29-36 8 p.

Research output: Contribution to journalArticle

Secretogranin II
Gonadotropin-Releasing Hormone
Rats
Chemical activation
Response Elements
37 Citations (Scopus)

Heterotypic interactions between transferrin receptor and transferrin receptor 2

Vogt, T. M., Blackwell, A. D., Giannetti, A. M., Bjorkman, P. J. & Enns, C., Mar 1 2003, In : Blood. 101, 5, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Erythroid Cells
Proteins
Hemochromatosis
36 Citations (Scopus)

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation

Zhang, A-S., Davies, P., Carlson, H. L. & Enns, C., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9500-9505 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Homeostasis
Iron
Mutation
53 Citations (Scopus)

Molecular mechanisms and regulation of iron transport

Chung, J., Wessling-Resnick, M. & Enns, C., 2003, In : Critical Reviews in Clinical Laboratory Sciences. 40, 2, p. 151-182 32 p.

Research output: Contribution to journalArticle

Iron
Tissue
Dietary Iron
Mitochondria
Transferrin