Research Output 1969 2019

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Article
2013
6 Citations (Scopus)
Glycosylation
Transferrin Receptors
Transferrin
Stabilization
Iron
2 Citations (Scopus)

Poker face no more: cancer recurrence reveals its hand.

Chan, C. J. & Coussens, L., Dec 2013, In : Nature Medicine. 19, 12, p. 1569-1570 2 p.

Research output: Contribution to journalArticle

T-cells
Tumors
Animals
Cytokines
40 Citations (Scopus)

Single-molecule fluorescence in situ hybridization: Quantitative imaging of single RNA molecules

Kwon, S., Feb 2013, In : BMB Reports. 46, 2, p. 65-72 8 p.

Research output: Contribution to journalArticle

Transcription
Fluorescence In Situ Hybridization
Fluorescence
RNA
Imaging techniques
28 Citations (Scopus)

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin

Wong, J., Smith, L. B., Magun, E. A., Engstrom, T., Kelley-Howard, K., Jandhyala, D. M., Thorpe, C. M., Magun, B. E. & Wood, L., Jan 2013, In : Cancer Biology and Therapy. 14, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

Doxorubicin
Phosphotransferases
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases

Some dcs are "b"etter

Ruffell, B. & Coussens, L., Apr 18 2013, In : Immunity. 38, 4, p. 626-628 3 p.

Research output: Contribution to journalArticle

Anthracyclines
Dendritic Cells
Immunity
Adenosine Triphosphate
Antigens
6 Citations (Scopus)

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

Wang, J., Chen, J., Enns, C. & Mayinger, P., Aug 1 2013, In : PLoS One. 8, 8, e71112.

Research output: Contribution to journalArticle

lysyllysine
Transferrin Receptors
transferrin
Cell membranes
Starvation
58 Citations (Scopus)

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma

Ganesan, A. P., Johansson, M., Ruffell, B., Beltran, A., Lau, J., Jablons, D. M. & Coussens, L., Aug 15 2013, In : Journal of Immunology. 191, 4, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Non-Small Cell Lung Carcinoma
T-Lymphocytes
Neoplasms
Granzymes
2012
1524 Citations (Scopus)

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D. & Coussens, L., Mar 20 2012, In : Cancer Cell. 21, 3, p. 309-322 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Crime
Neoplasms
Neoplastic Stem Cells
Stromal Cells
40 Citations (Scopus)
rho-Associated Kinases
Rosette Formation
Constriction
Actomyosin
Fibroblast Growth Factors
18 Citations (Scopus)

Hereditary hemochromatosis and transferrin receptor 2

Chen, J. & Enns, C., Mar 2012, In : Biochimica et Biophysica Acta - General Subjects. 1820, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Hemochromatosis
Iron
Hepcidins
Homeostasis
16 Citations (Scopus)

Iron Transport Machinery of Human Cells. Players and Their Interactions

Zhao, N. & Enns, C., 2012, In : Current Topics in Membranes. 69, p. 67-93 27 p.

Research output: Contribution to journalArticle

Iron
Mammals
46 Citations (Scopus)

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C., Ahmed, R. & Zhang, A-S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

Oligosaccharides
Cell membranes
matriptase 2
neogenin
Hepatocytes
1 Citation (Scopus)

Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin

Kassa, R., Monterroso, V., Wentzell, J., Ramos, A. L., Couchi, E., Lecomte, M. C., Iordanov, M., Kretzschmar, D., Nicolas, G. & Tshala-Katumbay, D., Jul 2012, In : Journal of Molecular Neuroscience. 47, 3, p. 631-638 8 p.

Research output: Contribution to journalArticle

Spectrin
Calpain
Caspases
Maintenance
Molecular Probes
48 Citations (Scopus)

Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing

Obholzer, N., Swinburne, I. A., Schwab, E., Nechiporuk, A., Nicolson, T. & Megason, S. G., Nov 15 2012, In : Development (Cambridge). 139, 22, p. 4280-4290 11 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Zebrafish
Organism Cloning
Genome
Mutation
26 Citations (Scopus)

Ricin and Shiga toxins: Effects on host cell Signal transduction

Jandhyala, D. M., Thorpe, C. M. & Magun, B., 2012, In : Current Topics in Microbiology and Immunology. 357, p. 41-65 25 p.

Research output: Contribution to journalArticle

Shiga Toxins
Ricin
Signal Transduction
Inflammasomes
Unfolded Protein Response
25 Citations (Scopus)

Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome

Vyleta, M. L., Wong, J. & Magun, B. E., May 14 2012, In : PLoS One. 7, 5, e36044.

Research output: Contribution to journalArticle

Inflammasomes
Potassium
Chemical activation
potassium
interleukin-1
263 Citations (Scopus)

Tumor microenvironment complexity: Emerging roles in cancer therapy

Swartz, M. A., Iida, N., Roberts, E. W., Sangaletti, S., Wong, M., Yull, F. E., Coussens, L. & DeClerck, Y. A., May 15 2012, In : Cancer Research. 72, 10, p. 2473-2480 8 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Neoplasms
Therapeutics
Lymphatic System
Stromal Cells
2011
2 Citations (Scopus)
Fas Ligand Protein
Dermatitis
Interferon-gamma
Gene Expression
Skin
19 Citations (Scopus)

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug

Copenhaver, P., Anekonda, T. S., Musashe, D., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. R. & Quinn, J., Sep 2011, In : DMM Disease Models and Mechanisms. 4, 5, p. 634-648 15 p.

Research output: Contribution to journalArticle

Isradipine
Alzheimer Disease
Amyloid
Biological Assay
Pharmaceutical Preparations
13 Citations (Scopus)

Chondrogenic and gliogenic subpopulations of neural crest play distinct roles during the assembly of epibranchial ganglia

Culbertson, M. D., Lewis, Z. R. & Nechiporuk, A., Sep 9 2011, In : PLoS One. 6, 9, e24443.

Research output: Contribution to journalArticle

neural crest
Neural Crest
Ganglia
Arches
Restoration
77 Citations (Scopus)

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

Sauter, K. A. D., Wood, L., Wong, J., Iordanov, M. & Magun, B. E., Jun 15 2011, In : Cancer Biology and Therapy. 11, 12, p. 1008-1016 9 p.

Research output: Contribution to journalArticle

Inflammasomes
Daunorubicin
Interleukin-1beta
Interleukin-1
Doxorubicin
43 Citations (Scopus)

Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium

McGraw, H. F., Drerup, C. M., Culbertson, M. D., Linbo, T., Raible, D. W. & Nechiporuk, A., Sep 15 2011, In : Development. 138, 18, p. 3921-3930 10 p.

Research output: Contribution to journalArticle

Zebrafish
Wnt Signaling Pathway
Stem Cells
Genes
18 Citations (Scopus)

Sortilin associates with transforming growth factor-β family proteins to enhance lysosome-mediated degradation

Kwon, S. & Christian, J. L., Jun 17 2011, In : Journal of Biological Chemistry. 286, 24, p. 21876-21885 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Lysosomes
Degradation
Protein Precursors
Proteins
66 Citations (Scopus)

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A-S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Liver
Rats
Transferrin
37 Citations (Scopus)

Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas

Dalgin, G., Ward, A. B., Hao, L. T., Beattie, C. E., Nechiporuk, A. & Prince, V. E., Nov 1 2011, In : Development. 138, 21, p. 4597-4608 12 p.

Research output: Contribution to journalArticle

Zebrafish
Islets of Langerhans
Tretinoin
Endoderm
Vertebrates
2010
24 Citations (Scopus)

Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis

Zhang, A-S., Nov 2010, In : Advances in Nutrition. 1, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Hepcidins
homeostasis
Homeostasis
Iron
iron
8 Citations (Scopus)

Generation of mice with a conditional allele for Ift172

Howard, P. W., Howard, T. L. & Maurer, R., Jan 2010, In : Transgenic Research. 19, 1, p. 121-126 6 p.

Research output: Contribution to journalArticle

Alleles
alleles
mice
Hedgehogs
Erinaceidae
52 Citations (Scopus)

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Gao, J., Chen, J., De Domenico, I., Koeller, D., Harding, C., Fleming, R. E., Koeberl, D. D. & Enns, C., Apr 22 2010, In : Blood. 115, 16, p. 3374-3381 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Iron
Liver
Genes
47 Citations (Scopus)
Proprotein Convertases
Hepcidins
Bone
Down-Regulation
Bone and Bones
22 Citations (Scopus)

Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain

Sopory, S., Kwon, S., Wehrli, M. & Christian, J. L., Oct 2010, In : Developmental Biology. 346, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

Ligands
Imaginal Discs
Mesoderm
Drosophila
Molecular Biology
3 Citations (Scopus)

Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134

Howard, P. W., Jue, S. F., Ransom, D. G. & Maurer, R., Jul 1 2010, In : Biochemical Journal. 429, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Ubiquitination
Carrier Proteins
Proteins
Proteasome Endopeptidase Complex
Kidney
31 Citations (Scopus)

Ricin toxin activates the NALP3 inflammasome

Lindauer, M., Wong, J. & Magun, B., Jun 2010, In : Toxins. 2, 6, p. 1500-1514 15 p.

Research output: Contribution to journalArticle

Inflammasomes
Ricin
Interleukin-1
Macrophages
Phosphorylation
11 Citations (Scopus)

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A-S. & Enns, C., Jan 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Liver
Proteins
Iron
Hepcidins
57 Citations (Scopus)

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A-S., Gao, J., Koeberl, D. D. & Enns, C., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Bone
Bone and Bones
Liver
5 Citations (Scopus)

Transcription intermediary factor 1γ decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1

Howard, P. W., Ransom, D. G. & Maurer, R., Jun 4 2010, In : Biochemical and Biophysical Research Communications. 396, 3, p. 674-678 5 p.

Research output: Contribution to journalArticle

Transcription factors
Transcription Factors
Proteins
transcriptional intermediary factor 1
Proteasome Inhibitors
22 Citations (Scopus)

ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells

Sauter, K. A. D., Magun, E. A., Iordanov, M. S. & Magun, B. E., Aug 1 2010, In : Cancer Biology and Therapy. 10, 3, p. 258-266 9 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Doxorubicin
Protein Kinases
Apoptosis
HeLa Cells
96 Citations (Scopus)

ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin

Zhao, N., Gao, J., Enns, C. & Knutson, M. D., Oct 15 2010, In : Journal of Biological Chemistry. 285, 42, p. 32141-32150 10 p.

Research output: Contribution to journalArticle

Transferrin
Iron
Proteins
Hep G2 Cells
HEK293 Cells
2009
4 Citations (Scopus)

Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1

Howard, P. W., Jue, S. F. & Maurer, R., 2009, In : Molecular Endocrinology. 23, 10, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

Synaptotagmin I
Transcription Factors
Genes
Exons
Binding Sites
58 Citations (Scopus)

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A-S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone
Bone and Bones
Proteins
Liver
205 Citations (Scopus)

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A-S. & Enns, C., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Transferrin
Iron
Hep G2 Cells
104 Citations (Scopus)

Iron homeostasis: Recently identified proteins provide insight into novel control mechanisms

Zhang, A-S. & Enns, C., Jan 9 2009, In : Journal of Biological Chemistry. 284, 2, p. 711-715 5 p.

Research output: Contribution to journalArticle

Homeostasis
Iron
Proteins
Superoxides
Biochemical Phenomena
86 Citations (Scopus)
Homeostasis
Iron
Hepcidins
Iron-Regulatory Proteins
Dietary Iron
29 Citations (Scopus)

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Maxson, J., Enns, C. & Zhang, A-S., Feb 19 2009, In : Blood. 113, 8, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cell membranes
Hepcidins
Bone Morphogenetic Proteins
Cell Membrane
43 Citations (Scopus)

Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling

Lindauer, M. L., Wong, J., Iwakura, Y. & Magun, B. E., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1419-1426 8 p.

Research output: Contribution to journalArticle

Ricin
Interleukin-1
Pneumonia
Macrophages
Neutrophil Infiltration

Reply

Gao, J., Chen, J., Zhang, A-S. & Enns, C., Sep 2009, In : Gastroenterology. 137, 3, p. 1175 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Reverse signaling by glycosylphosphatidylinositol-linked manduca ephrin requires a src family kinase to restrict neuronal migration in vivo

Coate, T. M., Swanson, T. L. & Copenhaver, P., Mar 18 2009, In : Journal of Neuroscience. 29, 11, p. 3404-3418 15 p.

Research output: Contribution to journalArticle

Ephrins
Manduca
Glycosylphosphatidylinositols
src-Family Kinases
Enteric Nervous System
45 Citations (Scopus)

Site-specific cleavage of BMP4 by furin, PC6, and PC7

Nelsen, S. & Christian, J. L., Oct 2 2009, In : Journal of Biological Chemistry. 284, 40, p. 27157-27166 10 p.

Research output: Contribution to journalArticle

Furin
Oocytes
Embryonic Structures
Peptide Hydrolases
Chemical activation
254 Citations (Scopus)

Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis

Harper, E. G., Guo, C., Rizzo, H., Lillis, J. V., Kurtz, S. E., Skorcheva, I., Purdy, D., Fitch, E., Iordanov, M. & Blauvelt, A., Sep 2009, In : Journal of Investigative Dermatology. 129, 9, p. 2175-2183 9 p.

Research output: Contribution to journalArticle

Interleukin-17
Keratinocytes
Psoriasis
Th17 Cells
Cytokines
34 Citations (Scopus)

Transferrin-directed internalization and cycling of transferrin receptor 2

Chen, J., Wang, J., Meyers, K. R. & Enns, C., Oct 2009, In : Traffic. 10, 10, p. 1488-1501 14 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Ubiquitination
Degradation
Recycling
2008
26 Citations (Scopus)

Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis: Recruitment of the epidermal growth factor receptor and activation of MAP kinases

Farley, S. M., Purdy, D. E., Ryabinina, O. P., Schneider, P., Magun, B. E. & Iordanov, M. S., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 919-928 10 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Epidermal Growth Factor Receptor
Epidermis
Phosphotransferases
Chemical activation