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2014

Mammary gland involution as an immunotherapeutic target for postpartum breast cancer

Fornetti, J., Martinson, H. A., Betts, C. B., Lyons, T. R., Jindal, S., Guo, Q., Coussens, L. M., Borges, V. F. & Schedin, P., Jul 2014, In : Journal of Mammary Gland Biology and Neoplasia. 19, 2, p. 213-228 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors

Cheung, L. W. T., Yu, S., Zhang, D., Li, J., Ng, P. K. S., Panupinthu, N., Mitra, S., Ju, Z., Yu, Q., Liang, H., Hawke, D. H., Lu, Y., Broaddus, R. R. & Mills, G. B., Oct 13 2014, In : Cancer Cell. 26, 4, p. 479-494 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Physiological COX-2 expression in breast epithelium associates with COX-2 levels in ductal carcinoma in situ and invasive breast cancer in young women

Fornetti, J., Jindal, S., Middleton, K. A., Borges, V. F. & Schedin, P., Apr 2014, In : American Journal of Pathology. 184, 4, p. 1219-1229 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling

Jindal, S., Gao, D., Bell, P., Albrektsen, G., Edgerton, S. M., Ambrosone, C. B., Thor, A. D., Borges, V. F. & Schedin, P., Mar 28 2014, In : Breast Cancer Research. 16, 2, R31.

Research output: Contribution to journalArticle

25 Scopus citations

Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs: Synergistic effects of doxorubicin and vincristine

Wong, J., Tran, L. T., Magun, E. A., Magun, B. E. & Wood, L. J., Oct 1 2014, In : Cancer Biology and Therapy. 15, 10, p. 1395-1403 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death

Chen, H., Huang, S., Han, X., Zhang, J., Shan, C., Tsang, Y. H., Ma, H. T. & Poon, R. Y. C., Apr 2014, In : Cell Death and Disease. 5, 4, e1177.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer

Panupinthu, N., Yu, S., Zhang, D., Zhang, F., Gagea, M., Lu, Y., Grandis, J. R., Dunn, S. E., Lee, H. Y. & Mills, G. B., May 29 2014, In : Oncogene. 33, 22, p. 2846-2856 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

Tilak, A., Nelsen, S. M., Kim, H. S., Donley, N., McKnite, A., Lee, H. & Christian, J. L., Aug 2014, In : Development (Cambridge). 141, 15, p. 3062-3071 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate

Lim, A., Shin, K., Zhao, C., Kawano, S. & Beachy, P. A., Dec 1 2014, In : Nature Cell Biology. 16, 12, p. 1135-1145 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells

Burger, K. L., Learman, B. S., Boucherle, A. K., Sirintrapun, S. J., Isom, S., Díaz, B., Courtneidge, S. A. & Seals, D. F., Feb 1 2014, In : Prostate. 74, 2, p. 134-148 15 p.

Research output: Contribution to journalArticle

36 Scopus citations

STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer

Nguyen, A. V., Wu, Y. Y. & Lin, E. Y., Aug 14 2014, In : World Journal of Gastroenterology. 20, 30, p. 10279-10287 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: A new role for lymphatic endothelial cells

Hirosue, S., Vokali, E., Raghavan, V. R., Rincon-Restrepo, M., Lund, A. W., Corthésy-Henrioud, P., Capotosti, F., Winter, C. H., Hugues, S. & Swartz, M. A., Jun 1 2014, In : Journal of Immunology. 192, 11, p. 5002-5011 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

Thomas, S. N., Vokali, E., Lund, A. W., Hubbell, J. A. & Swartz, M. A., Jan 1 2014, In : Biomaterials. 35, 2, p. 814-824 11 p.

Research output: Contribution to journalArticle

145 Scopus citations

Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation

Scandiuzzi, L., Ghosh, K., Hofmeyer, K. A., Abadi, Y. M., Lázár-Molnár, E., Lin, E. Y., Liu, Q., Jeon, H., Almo, S. C., Chen, L., Nathenson, S. G. & Zang, X., Feb 14 2014, In : Cell Reports. 6, 4, p. 625-632 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T. W., Dawson, D. W., Donahue, T. R., Masamune, A., Shimosegawa, T., Apte, M. V., Wilson, J. S., Ng, B., Lau, S. L. & 9 others, Gunton, J. E., Wahl, G. M., Hunter, T., Drebin, J. A., O'Dwyer, P. J., Liddle, C., Tuveson, D. A., Downes, M. & Evans, R. M., Sep 25 2014, In : Cell. 159, 1, p. 80-93 14 p.

Research output: Contribution to journalArticle

392 Scopus citations
2013

Amyloid precursor proteins interact with the heterotrimeric G protein go in the control of neuronal migration

Ramaker, J. M., Swanson, T. L. & Copenhaver, P. F., Jun 17 2013, In : Journal of Neuroscience. 33, 24, p. 10165-10181 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response

Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S. L., Atkins, A. R., Barish, G. D., Gunton, J. E., Liddle, C., Downes, M. & Evans, R. M., Apr 25 2013, In : Cell. 153, 3, p. 601-613 13 p.

Research output: Contribution to journalArticle

324 Scopus citations

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

Dillon, T. J., Takahashi, M., Li, Y., Tavisala, S., Murray, S. E., Moran, A. E., Parker, D. C. & Stork, P. J. S., Apr 1 2013, In : International Immunology. 25, 4, p. 259-269 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

Ruffell, B., Affara, N. I., Cottone, L., Junankar, S., Johansson, M., DeNardo, D. G., Korets, L., Reinheckel, T., Sloane, B. F., Bogyo, M. & Coussens, L. M., Oct 1 2013, In : Genes and Development. 27, 19, p. 2086-2098 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Collagen architecture in pregnancy-induced protection from breast cancer

Maller, O., Hansen, K. C., Lyons, T. R., Acerbi, I., Weaver, V. M., Prekeris, R., Tan, A. C. & Schedin, P., Oct 18 2013, In : Journal of Cell Science. 126, 18, p. 4108-4120 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells

Strachan, D. C., Ruffell, B., Oei, Y., Bissell, M. J., Coussens, L. M., Pryer, N. & Daniel, D., Jan 1 2013, In : OncoImmunology. 2, 12, e26968.

Research output: Contribution to journalArticle

158 Scopus citations

Exploratory bioinformatics study of lncRNAs in Alzheimer's disease mRNA sequences with application to drug development

Holden, T., Nguyen, A., Lin, E., Cheung, E., Dehipawala, S., Ye, J., Tremberger, G., Lieberman, D. & Cheung, T., May 13 2013, In : Computational and Mathematical Methods in Medicine. 2013, 579136.

Research output: Contribution to journalArticle

13 Scopus citations

Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation

Boell, L., Pallares, L. F., Brodski, C., Chen, Y., Christian, J. L., Kousa, Y. A., Kuss, P., Nelsen, S., Novikov, O., Schutte, B. C., Wang, Y. & Tautz, D., Sep 1 2013, In : Development Genes and Evolution. 223, 5, p. 279-287 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J., Chen, J., Enns, C. & Wessling-Resnick, M., Jul 23 2013, In : PloS one. 8, 7, e70199.

Research output: Contribution to journalArticle

16 Scopus citations

Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in Zebrafish

McCarroll, M. N. & Nechiporuk, A. V., Dec 17 2013, In : PloS one. 8, 12, e85087.

Research output: Contribution to journalArticle

9 Scopus citations

Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone

Harvell, D. M. E., Kim, J., O'Brien, J., Tan, A. C., Borges, V. F., Schedin, P., Jacobsen, B. M. & Horwitz, K. B., Mar 12 2013, In : Hormones and Cancer. 4, 3, p. 140-153 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hypothesized role of pregnancy hormones on HER2+ breast tumor development

Cruz, G. I., Martínez, M. E., Natarajan, L., Wertheim, B. C., Gago-Dominguez, M., Bondy, M., Daneri-Navarro, A., Meza-Montenegro, M. M., Gutierrez-Millan, L. E., Brewster, A., Schedin, P., Komenaka, I. K., Castelao, J. E., Carracedo, A., Redondo, C. M. & Thompson, P. A., Jan 1 2013, In : Breast Cancer Research and Treatment. 137, 1, p. 237-246 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A. S., Apr 2 2013, In : PloS one. 8, 4, e60534.

Research output: Contribution to journalArticle

38 Scopus citations

Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17

Howard, P. W., Jue, S. F. & Maurer, R. A., Aug 15 2013, In : Experimental Cell Research. 319, 14, p. 2275-2281 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Intravital Immunofluorescence for Visualizing the Microcirculatory and Immune Microenvironments in the Mouse Ear Dermis

Kilarski, W. W., Güç, E., Teo, J. C. M., Oliver, S. R., Lund, A. W. & Swartz, M. A., Feb 25 2013, In : PloS one. 8, 2, e57135.

Research output: Contribution to journalArticle

45 Scopus citations

Iron regulation by hepcidin

Zhao, N., Zhang, A. S. & Enns, C. A., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

Drerup, C. M. & Nechiporuk, A. V., Feb 1 2013, In : PLoS genetics. 9, 2, e1003303.

Research output: Contribution to journalArticle

61 Scopus citations

Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy

Haricharan, S., Dong, J., Hein, S., Reddy, J. P., Du, Z., Toneff, M., Holloway, K., Hilsenbeck, S. G., Huang, S., Atkinson, R., Woodward, W., Jindal, S., Borges, V. F., Gutierrez, C., Zhang, H., Schedin, P. J., Osborne, C. K., Tweardy, D. J. & Li, Y., Dec 31 2013, In : eLife. 2013, 2, e00996.

Research output: Contribution to journalArticle

22 Scopus citations
6 Scopus citations

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

Díaz, B., Yuen, A., Iizuka, S., Higashiyama, S. & Courtneidge, S. A., Apr 15 2013, In : Journal of Cell Biology. 201, 2, p. 279-292 14 p.

Research output: Contribution to journalArticle

78 Scopus citations

Poker face no more: Cancer recurrence reveals its hand

Chan, C. J. & Coussens, L. M., Dec 2013, In : Nature medicine. 19, 12, p. 1569-1570 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer

Callihan, E. B., Gao, D., Jindal, S., Lyons, T. R., Manthey, E., Edgerton, S., Urquhart, A., Schedin, P. & Borges, V. F., Apr 1 2013, In : Breast Cancer Research and Treatment. 138, 2, p. 549-559 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

Jacob, A., Jing, J., Lee, J., Schedin, P., Gilbert, S. M., Peden, A. A., Junutula, J. R. & Prekeris, R., Oct 18 2013, In : Journal of Cell Science. 126, 20, p. 4647-4658 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting

Westenskow, P. D., Kurihara, T., Aguilar, E., Scheppke, E. L., Moreno, S. K., Wittgrove, C., Marchetti, V., Michael, I. P., Anand, S., Nagy, A., Cheresh, D. & Friedlander, M., Nov 1 2013, In : Journal of Clinical Investigation. 123, 11, p. 4900-4908 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

RNAi screens in mice identify physiological regulators of oncogenic growth

Beronja, S., Janki, P., Heller, E., Lien, W. H., Keyes, B. E., Oshimori, N. & Fuchs, E., Aug 15 2013, In : Nature. 501, 7466, p. 185-190 6 p.

Research output: Contribution to journalArticle

98 Scopus citations

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin

Wong, J., Smith, L. B., Magun, E. A., Engstrom, T., Kelley-Howard, K., Jandhyala, D. M., Thorpe, C. M., Magun, B. E. & Wood, L. J., Jan 1 2013, In : Cancer Biology and Therapy. 14, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon

Nguyen, A. V., Wu, Y. Y., Liu, Q., Wang, D., Nguyen, S., Loh, R., Pang, J., Friedman, K., Orlofsky, A., Augenlicht, L., Pollard, J. W. & Lin, E. Y., Sep 2013, In : Neoplasia (United States). 15, 9, p. 998-1008 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization

Wang, J., Chen, J., Enns, C. A. & Mayinger, P., Aug 1 2013, In : PloS one. 8, 8, e71112.

Research output: Contribution to journalArticle

6 Scopus citations

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma

Ganesan, A. P., Johansson, M., Ruffell, B., Beltran, A., Lau, J., Jablons, D. M. & Coussens, L. M., Aug 15 2013, In : Journal of Immunology. 191, 4, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

63 Scopus citations
2012

Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling

Ramirez, R. A., Lee, A., Schedin, P., Russell, J. S. & Masso-Welch, P. A., May 1 2012, In : Developmental Dynamics. 241, 5, p. 890-900 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Annexin A5 binds to lipopolysaccharide and reduces its endotoxin activity

Rand, J. H., Wu, X. X., Lin, E. Y., Griffel, A., Gialanella, P. & McKitrick, J. C., Mar 1 2012, In : mBio. 3, 2

Research output: Contribution to journalArticle

27 Scopus citations

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration

Chen, T., Heller, E., Beronja, S., Oshimori, N., Stokes, N. & Fuchs, E., May 3 2012, In : Nature. 485, 7396, p. 104-108 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

Antigen-independent differentiation and maintenance of effector-like resident memory T Cells in tissues

Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V. & Masopust, D., May 15 2012, In : Journal of Immunology. 188, 10, p. 4866-4875 10 p.

Research output: Contribution to journalArticle

276 Scopus citations

Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma

Munson, J. M., Fried, L., Rowson, S. A., Bonner, M. Y., Karumbaiah, L., Diaz, B., Courtneidge, S. A., Knaus, U. G., Brat, D. J., Arbiser, J. L. & Bellamkonda, R. V., Mar 28 2012, In : Science translational medicine. 4, 127, 127ra36.

Research output: Contribution to journalArticle

64 Scopus citations

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation

Huang, M., Anand, S., Murphy, E. A., Desgrosellier, J. S., Stupack, D. G., Shattil, S. J., Schlaepfer, D. D. & Cheresh, D. A., May 31 2012, In : Oncogene. 31, 22, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

40 Scopus citations