Research Output 1969 2019

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2016
5 Citations (Scopus)

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma

Iizuka, S., Abdullah, C., Buschman, M. D., Diaz, B. & Courtneidge, S., 2016, In : Oncotarget. 7, 48, p. 78473-78486 14 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Growth
Proteins
Extracellular Matrix
2 Citations (Scopus)

Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos

Green, Y. S., Kwon, S., Mimoto, M. S., Xie, Y. & Christian, J. L., Nov 1 2016, In : Development (Cambridge). 143, 21, p. 4016-4026 11 p.

Research output: Contribution to journalArticle

Gastrulation
Mesoderm
Xenopus
Embryonic Structures
Ectoderm
2015
20 Citations (Scopus)

A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium

Bethea, T. N., Rosenberg, L., Hong, C. C., Troester, M. A., Lunetta, K. L., Bandera, E. V., Schedin, P., Kolonel, L. N., Olshan, A. F., Ambrosone, C. B. & Palmer, J. R., 2015, In : Breast cancer research : BCR. 17, p. 22 1 p.

Research output: Contribution to journalArticle

Oral Contraceptives
African Americans
Epidemiology
Breast Neoplasms
Odds Ratio
9 Citations (Scopus)

CD81 Promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression

Chen, J. & Enns, C., Mar 20 2015, In : Journal of Biological Chemistry. 290, 12, p. 7841-7850 10 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Maintenance
Degradation
Iron
6 Citations (Scopus)

GATA2 regulates Wnt signaling to promote primitive red blood cell fate

Mimoto, M. S., Kwon, S., Green, Y. S., Goldman, D. & Christian, J. L., Nov 1 2015, In : Developmental Biology. 407, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Ectoderm
Mesoderm
Erythrocytes
GATA2 Transcription Factor
Gastrulation
38 Citations (Scopus)

Immune Response to Cancer Therapy: Mounting an Effective Antitumor Response and Mechanisms of Resistance

Medler, T. R., Cotechini, T. & Coussens, L., Sep 1 2015, In : Trends in Cancer. 1, 1, p. 66-75 10 p.

Research output: Contribution to journalArticle

Radiotherapy
Drug Therapy
T-Lymphocytes
Neoplasms
Therapeutics
23 Citations (Scopus)

Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women

Ambrosone, C. B., Zirpoli, G., Hong, C. C., Yao, S., Troester, M. A., Bandera, E. V., Schedin, P., Bethea, T. N., Borges, V., Park, S. Y., Chandra, D., Rosenberg, L., Kolonel, L. N., Olshan, A. F. & Palmer, J. R., Sep 1 2015, In : Journal of the National Cancer Institute. 107, 9, djv172.

Research output: Contribution to journalArticle

Menarche
Estrogen Receptors
African Americans
Breast Neoplasms
Live Birth
7 Citations (Scopus)

In vivo analysis of axonal transport in zebrafish

Drerup, C. M. & Nechiporuk, A., 2015, (Accepted/In press) In : Methods in Cell Biology.

Research output: Contribution to journalArticle

Axonal Transport
Zebrafish
Nervous System
Synapses
Physiological Phenomena
26 Citations (Scopus)

Low intracellular iron increases the stability of Matriptase-2

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. & Zhang, A-S., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 4432-4446 15 p.

Research output: Contribution to journalArticle

Iron
Hepcidins
Hepatocytes
Homeostasis
Stabilization
356 Citations (Scopus)

Macrophages and therapeutic resistance in cancer

Ruffell, B. & Coussens, L., Apr 13 2015, In : Cancer Cell. 27, 4, p. 462-472 11 p.

Research output: Contribution to journalArticle

Macrophages
Tumor Microenvironment
Neoplasms
Critical Pathways
Therapeutics
6 Citations (Scopus)

Molecular phenotype of breast cancer according to time since last pregnancy in a large cohort of young women

Collins, L. C., Gelber, S., Marotti, J. D., White, S., Ruddy, K., Brachtel, E. F., Schapira, L., Come, S. E., Borges, V. F., Schedin, P., Warner, E., Wensley, T., Tamimi, R. M., Winer, E. P. & Partridge, A. H., May 29 2015, In : Oncologist. 20, 7, p. 713-718 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Phenotype
Pregnancy
Parity
Birth Intervals
17 Citations (Scopus)

Myeloid Cells as Targets for Therapy in Solid Tumors

Cotechini, T., Medler, T. R. & Coussens, L., Jul 5 2015, In : Cancer Journal (United States). 21, 4, p. 343-350 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
Neoplasms
Therapeutics
Tumor Microenvironment
Cytotoxic T-Lymphocytes
17 Citations (Scopus)

Myoepithelial cell differentiation markers in ductal carcinoma in situ progression

Russell, T. D., Jindal, S., Agunbiade, S., Gao, D., Troxell, M., Borges, V. F. & Schedin, P., Nov 1 2015, In : American Journal of Pathology. 185, 11, p. 3076-3089 14 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Differentiation Antigens
Cell Differentiation
Breast
Smooth Muscle
6 Citations (Scopus)

Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression

Cuevas, I., Layman, H., Coussens, L. & Boudreau, N., Mar 30 2015, In : PLoS One. 10, 3, e0121720.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Endothelial cells
angiogenesis
Tumors
neoplasms
86 Citations (Scopus)

TH2-polarized CD4+ T Cells and macrophages limit efficacy of radiotherapy

Shiao, S. L., Ruffell, B., De Nardo, D. G., Faddegon, B. A., Park, C. C. & Coussens, L., May 1 2015, In : Cancer immunology research. 3, 5, p. 518-525 8 p.

Research output: Contribution to journalArticle

Radiotherapy
Macrophages
Breast Neoplasms
T-Lymphocytes
Interleukin-4
23 Citations (Scopus)

The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo

Blouw, B., Patel, M., Iizuka, S., Abdullah, C., You, W. K., Huang, X., Li, J. L., Diaz, B., Stallcup, W. B. & Courtneidge, S., Mar 31 2015, In : PLoS One. 10, 3, e0121003.

Research output: Contribution to journalArticle

scaffolding proteins
human growth
Scaffolds
breast neoplasms
Tumors
11 Citations (Scopus)

The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo

Neugebauer, J. M., Kwon, S., Kim, H. S., Donley, N., Tilak, A., Sopory, S. & Christian, J. L., May 5 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 18, p. E2307-E2316

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 7
Ligands
Protein Precursors
Bone Diseases
57 Citations (Scopus)

Tumor mechanics and metabolic dysfunction

Tung, J. C., Barnes, J. M., Desai, S. R., Sistrunk, C., Conklin, M. W., Schedin, P., Eliceiri, K. W., Keely, P. J., Seewaldt, V. L. & Weaver, V. M., 2015, In : Free Radical Biology and Medicine. 79, p. 269-280 12 p.

Research output: Contribution to journalArticle

Mechanics
Extracellular Matrix
Tumors
Metabolism
Neoplasms
34 Citations (Scopus)

Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression

Martinson, H. A., Jindal, S., Durand-Rougely, C., Borges, V. F. & Schedin, P., Apr 15 2015, In : International Journal of Cancer. 136, 8, p. 1803-1813 11 p.

Research output: Contribution to journalArticle

Postnatal Care
Human Mammary Glands
Wound Healing
Postpartum Period
Breast Neoplasms
2014
56 Citations (Scopus)

A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

Keenan, B. P., Saenger, Y., Kafrouni, M. I., Leubner, A., Lauer, P., Maitra, A., Rucki, A. A., Gunderson, A. J., Coussens, L., Brockstedt, D. G., Dubensky, T. W., Hassan, R., Armstrong, T. D. & Jaffee, E. M., 2014, In : Gastroenterology. 146, 7

Research output: Contribution to journalArticle

Listeria
Carcinoma in Situ
Pancreatic Neoplasms
Immunity
Vaccines
24 Citations (Scopus)
Membrane Transport Proteins
Glycosylation
Iron
Metals
Cell Membrane
5 Citations (Scopus)

Antiphospholipid antibodies promote tissue factor-dependent angiogenic switch and tumor progression

Wu, Y. Y., Nguyen, A. V., Wu, X. X., Loh, M., Vu, M., Zou, Y., Liu, Q., Guo, P., Wang, Y., Montgomery, L. L., Orlofsky, A., Rand, J. H. & Lin, E., Dec 1 2014, In : American Journal of Pathology. 184, 12, p. 3359-3375 17 p.

Research output: Contribution to journalArticle

Antiphospholipid Antibodies
Thromboplastin
Neoplasms
Autoantibodies
Pericytes
117 Citations (Scopus)

B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas

Affara, N. I., Ruffell, B., Medler, T. R., Gunderson, A. J., Johansson, M., Bornstein, S., Bergsland, E., Steinhoff, M., Li, Y., Gong, Q., Ma, Y., Wiesen, J., Wong, M., Kulesz-Martin, M., Irving, B. & Coussens, L., Jun 16 2014, In : Cancer Cell. 25, 6, p. 809-821 13 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
B-Lymphocytes
Macrophages
Phenotype
Drug Therapy
192 Citations (Scopus)

Classification of current anticancer immunotherapies

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J. M., Buqué, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J. P., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J. Y., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E. & 68 others, Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucíková, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jäger, D., Kalinski, P., Kärre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J. P., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautès-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W. & Kroemer, G., 2014, In : Oncotarget. 5, 24, p. 12472-12508 37 p.

Research output: Contribution to journalArticle

Immunotherapy
Immune System
Neoplasms
Neoplasm Antigens
United States Food and Drug Administration
14 Citations (Scopus)

Duality of the immune response in cancer: lessons learned from skin

Medler, T. R. & Coussens, L., 2014, In : The Journal of investigative dermatology. 134, e1, p. E23-E28

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Cytotoxic T-Lymphocytes
Skin Neoplasms
Immune System
Inflammation
12 Citations (Scopus)

Genetic disruption of the Sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of Tks5

Cejudo-Martin, P., Yuen, A., Vlahovich, N., Lock, P., Courtneidge, S. & Díaz, B., Sep 26 2014, In : PLoS One. 9, 9, e107674.

Research output: Contribution to journalArticle

Essential Genes
gene targeting
exons
Exons
Protein Isoforms
71 Citations (Scopus)

Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors

Shin, K., Lim, A., Zhao, C., Sahoo, D., Pan, Y., Spiekerkoetter, E., Liao, J. C. & Beachy, P. A., Oct 13 2014, In : Cancer Cell. 26, 4, p. 521-533 13 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Medulloblastoma
Basal Cell Carcinoma
Tacrolimus
Pancreatic Neoplasms
124 Citations (Scopus)

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

Leong, H. S., Robertson, A. E., Stoletov, K., Leith, S. J., Chin, C. A., Chien, A. E., Hague, M. N., Ablack, A., Carmine-Simmen, K., McPherson, V. A., Postenka, C., Turley, E. A., Courtneidge, S., Chambers, A. F. & Lewis, J. D., 2014, In : Cell Reports. 8, 5, p. 1558-1570 13 p.

Research output: Contribution to journalArticle

Cells
Neoplasm Metastasis
Cortactin
Neoplasms
Therapeutics
8 Citations (Scopus)

Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish

McGraw, H. F., Culbertson, M. D. & Nechiporuk, A., 2014, In : Development (Cambridge). 141, 16, p. 3212-3221 10 p.

Research output: Contribution to journalArticle

Zebrafish
Lateral Line System
Phenotype
Proteins
Cell Transplantation
11 Citations (Scopus)

Long-term intravital immunofluorescence imaging of tissue matrix components with epifluorescence and two-photon microscopy

Güç, E., Fankhauser, M., Lund, A., Swartz, M. A. & Kilarski, W. W., Apr 22 2014, In : Journal of Visualized Experiments. 86, e51388.

Research output: Contribution to journalArticle

Photons
Fluorescent Antibody Technique
Tumors
Microscopy
Microscopic examination
252 Citations (Scopus)

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

Ruffell, B., Chang-Strachan, D., Chan, V., Rosenbusch, A., Ho, C. M. T., Pryer, N., Daniel, D., Hwang, E. S., Rugo, H. S. & Coussens, L., Nov 10 2014, In : Cancer Cell. 26, 5, p. 623-637 15 p.

Research output: Contribution to journalArticle

Interleukin-12
Interleukin-10
Dendritic Cells
Macrophages
T-Lymphocytes
13 Citations (Scopus)

Mammary gland involution as an immunotherapeutic target for postpartum breast cancer

Fornetti, J., Martinson, H. A., Betts, C. B., Lyons, T. R., Jindal, S., Guo, Q., Coussens, L., Borges, V. F. & Schedin, P., 2014, In : Journal of Mammary Gland Biology and Neoplasia. 19, 2, p. 213-228 16 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Postpartum Period
Breast Neoplasms
Neoplasms
Immunotherapy
3 Citations (Scopus)

Manipulating MicroRNAs to regulate macrophage polarization in gliomas

Anand, S. & Coussens, L., Aug 1 2014, In : Journal of the National Cancer Institute. 106, 8, dju230.

Research output: Contribution to journalArticle

MicroRNAs
Glioma
Macrophages
23 Citations (Scopus)

Postpartum breast involution reveals regression of secretory lobules mediated by tissue-remodeling

Jindal, S., Gao, D., Bell, P., Albrektsen, G., Edgerton, S. M., Ambrosone, C. B., Thor, A. D., Borges, V. F. & Schedin, P., Mar 28 2014, In : Breast Cancer Research. 16, 2, R31.

Research output: Contribution to journalArticle

Postpartum Period
Breast
Lactation
Human Mammary Glands
Breast Neoplasms
6 Citations (Scopus)

Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

Tilak, A., Nelsen, S., Kim, H. S., Donley, N., McKnite, A., Lee, H. & Christian, J. L., 2014, In : Development (Cambridge). 141, 15, p. 3062-3071 10 p.

Research output: Contribution to journalArticle

Ligands
Point Mutation
Embryonic Development
21 Citations (Scopus)

Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate

Lim, A., Shin, K., Zhao, C., Kawano, S. & Beachy, P. A., Dec 1 2014, In : Nature Cell Biology. 16, 12, p. 1135-1145 11 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Prostate
Morphogenesis
Prostatic Hyperplasia
Stromal Cells
28 Citations (Scopus)

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

Worthen, C. A. & Enns, C., 2014, In : Frontiers in Pharmacology. 5 MAR, Article 034.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Hepcidins
Homeostasis
Iron
37 Citations (Scopus)

The roles and regulation of multicellular rosette structures during morphogenesis

Harding, M. J., McGraw, H. F. & Nechiporuk, A., 2014, In : Development (Cambridge). 141, 13, p. 2549-2558 10 p.

Research output: Contribution to journalArticle

Rosette Formation
Morphogenesis
Stem Cell Niche
Adult Stem Cells
Neural Stem Cells
2013
27 Citations (Scopus)

Amyloid precursor proteins interact with the heterotrimeric G protein go in the control of neuronal migration

Ramaker, J. M., Swanson, T. L. & Copenhaver, P., 2013, In : Journal of Neuroscience. 33, 24, p. 10165-10181 17 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Heterotrimeric GTP-Binding Proteins
Amyloid beta-Protein Precursor
Nervous System
Amyloid
32 Citations (Scopus)

B cells and their mediators as targets for therapy in solid tumors

Gunderson, A. J. & Coussens, L., Jul 1 2013, In : Experimental Cell Research. 319, 11, p. 1644-1649 6 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Neoplasms
Therapeutics
Antigen Presentation
Immunoglobulins
137 Citations (Scopus)

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells

Strachan, D. C., Ruffell, B., Oei, Y., Bissell, M. J., Coussens, L., Pryer, N. & Daniel, D., 2013, In : OncoImmunology. 2, 12, e26968.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Macrophages
Breast Neoplasms
T-Lymphocytes
24 Citations (Scopus)

Dendritic cells, inflammation, and breast cancer

Palucka, K., Coussens, L. & O'Shaughnessy, J., Nov 2013, In : Cancer Journal (United States). 19, 6, p. 511-516 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Breast Neoplasms
Inflammation
Neoplasms
Cell Biology
26 Citations (Scopus)

Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation

Boell, L., Pallares, L. F., Brodski, C., Chen, Y., Christian, J. L., Kousa, Y. A., Kuss, P., Nelsen, S., Novikov, O., Schutte, B. C., Wang, Y. & Tautz, D., Sep 2013, In : Development Genes and Evolution. 223, 5, p. 279-287 9 p.

Research output: Contribution to journalArticle

Gene Dosage
Genetic Models
Mandible
Genes
Quantitative Trait Loci
14 Citations (Scopus)

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Byrne, S. L., Buckett, P. D., Kim, J., Luo, F., Sanford, J., Chen, J., Enns, C. & Wessling-Resnick, M., Jul 23 2013, In : PLoS One. 8, 7, e70199.

Research output: Contribution to journalArticle

Transferrin Receptors
transferrin
Degradation
receptors
degradation
7 Citations (Scopus)

Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in Zebrafish

McCarroll, M. N. & Nechiporuk, A., Dec 17 2013, In : PLoS One. 8, 12, e85087.

Research output: Contribution to journalArticle

neurogenesis
Fibroblast Growth Factors
sense organs
Neurogenesis
Cell proliferation
37 Citations (Scopus)

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A-S., Apr 2 2013, In : PLoS One. 8, 4, e60534.

Research output: Contribution to journalArticle

Liver
hepatocytes
Hepatocytes
Iron
iron
8 Citations (Scopus)

Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17

Howard, P. W., Jue, S. F. & Maurer, R., Aug 15 2013, In : Experimental Cell Research. 319, 14, p. 2275-2281 7 p.

Research output: Contribution to journalArticle

Carrier Proteins
Cilia
Immunoprecipitation
Kinesin
Cell-Free System
103 Citations (Scopus)

Iron regulation by hepcidin

Zhao, N., Zhang, A-S. & Enns, C., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Erythropoiesis
Bone Morphogenetic Protein 6
Bone Morphogenetic Protein Receptors
60 Citations (Scopus)

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

Drerup, C. M. & Nechiporuk, A., Feb 2013, In : PLoS Genetics. 9, 2, e1003303.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
lysosomes
Lysosomes
mitogen-activated protein kinase
Protein Kinases
500 Citations (Scopus)

Neutralizing tumor-promoting chronic inflammation: A magic bullet?

Coussens, L., Zitvogel, L. & Palucka, A. K., Jan 18 2013, In : Science. 339, 6117, p. 286-291 6 p.

Research output: Contribution to journalArticle

Magic
Inflammation
Neoplasms
Blood Vessels
Radiotherapy