Research Output 1969 2019

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2017
24 Citations (Scopus)

Invadosomes are coming: New insights into function and disease relevance

Paterson, E. K. & Courtneidge, S., 2017, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Adhesion
Actins
Pseudopodia
Fusion reactions
Cells
6 Citations (Scopus)

Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection

Loo, C. P., Nelson, N. A., Lane, R. S., Booth, J. L., Loprinzi Hardin, S. C., Thomas, A., Slifka, M., Nolz, J. & Lund, A., Sep 26 2017, In : Cell Reports. 20, 13, p. 3176-3187 12 p.

Research output: Contribution to journalArticle

Lymphatic Vessels
Pathogens
Virus Diseases
Chemical activation
Pathology
14 Citations (Scopus)

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo

Bruno, R. D., Fleming, J. M., George, A. L., Boulanger, C. A., Schedin, P. & Smith, G. H., Jan 10 2017, In : Scientific Reports. 7, 40196.

Research output: Contribution to journalArticle

Human Mammary Glands
Embryonic Stem Cells
Extracellular Matrix
Breast
Adipose Tissue
18 Citations (Scopus)

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Wahedi, M., Wortham, A. M., Kleven, M. D., Zhao, N., Jue, S., Enns, C. & Zhang, A-S., 2017, In : Journal of Biological Chemistry. 292, 44, p. 18354-18371 18 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Bone Morphogenetic Protein Receptors
Transferrin Receptors
Liver
11 Citations (Scopus)

Metformin accumulation correlates with organic cation transporter 2 protein expression and predicts mammary tumor regression in vivo

Checkley, L. A., Rudolph, M. C., Wellberg, E. A., Giles, E. D., Wahdan-Alaswad, R. S., Houck, J. A., Edgerton, S. M., Thor, A. D., Schedin, P., Anderson, S. M. & MacLean, P. S., Mar 1 2017, In : Cancer Prevention Research. 10, 3, p. 198-207 10 p.

Research output: Contribution to journalArticle

Metformin
Cations
Breast Neoplasms
Proteins
High Fat Diet
6 Citations (Scopus)

Physiologically activated mammary fibroblasts promote postpartum mammary cancer

Guo, Q., Minnier, J., Burchard, J., Chiotti, K., Spellman, P. & Schedin, P., Mar 23 2017, In : JCI insight. 2, 6, p. e89206

Research output: Contribution to journalArticle

Open Access
Postpartum Period
Breast
Fibroblasts
Breast Neoplasms
Neoplasms
2 Citations (Scopus)

Quantitative, in situ analysis of mRNAs and proteins with subcellular resolution

Kwon, S., Chin, K-Y., Nederlof, M. & Gray, J., Dec 1 2017, In : Scientific Reports. 7, 1, 16459.

Research output: Contribution to journalArticle

Messenger RNA
Breast Neoplasms
Fluorescent Antibody Technique
Proteins
RNA
78 Citations (Scopus)

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T., Kumar, S., Borkar, R. N., Azimi, V., Thibault, G., Chang, Y. H., Balter, A., Kawashima, R., Choe, G., Sauer, D., El Rassi, E., Clayburgh, D., Kulesz-Martin, M., Lutz, E. R., Zheng, L., Jaffee, E. M., Leyshock, P., Margolin, A., Mori, M. T., Gray, J. & 2 others, Flint, P. & Coussens, L., Apr 4 2017, In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Contribution to journalArticle

Tumors
Immunohistochemistry
Tissue
Biomarkers
Papillomaviridae
8 Citations (Scopus)

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

Drerup, C. M., Herbert, A. L., Monk, K. & Nechiporuk, A., Apr 17 2017, In : eLife. 6, e22234.

Research output: Contribution to journalArticle

Mitochondria
Axons
Dyneins
Zebrafish
Dynactin Complex
6 Citations (Scopus)
Heterotrimeric GTP-Binding Proteins
Amyloid beta-Protein Precursor
GTP-Binding Proteins
Alzheimer Disease
Neurons
37 Citations (Scopus)

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, M., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., Leblanc, M., Collisson, E. A., Asara, J. M., Kimmelman, A. C., Downes, M. & Evans, R. M., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1129-1134 6 p.

Research output: Contribution to journalArticle

Metabolome
Pancreatic Neoplasms
Cues
Adenocarcinoma
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Tumors
Breast
Tumor Burden
3 Citations (Scopus)

The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer

Wellberg, E. A., Checkley, L. A., Giles, E. D., Johnson, S. J., Oljira, R., Wahdan-Alaswad, R., Foright, R. M., Dooley, G., Edgerton, S. M., Jindal, S., Johnson, G. C., Richer, J. K., Kabos, P., Thor, A. D., Schedin, P., MacLean, P. S. & Anderson, S. M., Jul 24 2017, (Accepted/In press) In : Hormones and Cancer. p. 1-17 17 p.

Research output: Contribution to journalArticle

Androgen Receptors
Obesity
Breast Neoplasms
Neoplasms
Estrogen Receptors
11 Citations (Scopus)

The rodent liver undergoes weaning-induced involution and supports breast cancer metastasis

Goddard, E. T., Hill, R. C., Nemkov, T., D’Alessandro, A., Hansen, K. C., Maller, O., Mongoue-Tchokote, S., Mori, M. T., Partridge, A. H., Borges, V. F. & Schedin, P., Feb 1 2017, In : Cancer Discovery. 7, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

Weaning
Rodentia
Breast Neoplasms
Neoplasm Metastasis
Liver
3 Citations (Scopus)

The tumor suppressor, P53, decreases the metal transporter, ZIP14

Zhao, N., Zhang, A-S., Wortham, A. M., Jue, S., Knutson, M. D. & Enns, C., Dec 8 2017, In : Nutrients. 9, 12, 1335.

Research output: Contribution to journalArticle

transporters
Iron
Metals
metals
iron
5 Citations (Scopus)

Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis

Liu, Y., Wang, Z., De La Torre, R., Barling, A., Tsujikawa, T., Hornick, N., Hanifin, J., Simpson, E., Wang, Y., Swanzey, E., Wortham, A., Ding, H., Coussens, L. & Kulesz-Martin, M., Feb 1 2017, In : Journal of Investigative Dermatology. 137, 2, p. 359-366 8 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Immunity
Skin
Knockout Mice
CC Chemokines
37 Citations (Scopus)

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Fankhauser, M., Broggi, M. A. S., Potin, L., Bordry, N., Jeanbart, L., Lund, A., Da Costa, E., Hauert, S., Rincon-Restrepo, M., Tremblay, C., Cabello, E., Homicsko, K., Michielin, O., Hanahan, D., Speiser, D. E. & Swartz, M. A., Sep 13 2017, In : Science Translational Medicine. 9, 407, eaal4712.

Research output: Contribution to journalArticle

Lymphangiogenesis
Vascular Endothelial Growth Factor C
Immunotherapy
Melanoma
T-Lymphocytes
1 Citation (Scopus)

Understanding and Resetting Radiation Sensitivity in Rectal Cancer

Kelley, K. A., Ruhl, R. A., Rana, S. R., Dewey, E., Espinosa, C., Thomas, C., Martindale, R., Anand, S. & Tsikitis, V., Jul 24 2017, (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Radiation Tolerance
Rectal Neoplasms
MicroRNAs
Chemoradiotherapy
Colorectal Neoplasms
5 Citations (Scopus)

Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters

Zane, H. K., Doh, J. K., Enns, C. & Beatty, K., Mar 2 2017, In : ChemBioChem. 18, 5, p. 470-474 5 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Fluorophores
Proteins
Quantum Dots
1 Citation (Scopus)

Winter is coming: Tumor cells go into hibernation

Lund, A., Feb 15 2017, In : Science Translational Medicine. 9, 377, eaam6063.

Research output: Contribution to journalArticle

Hibernation
Tumor Microenvironment
Neoplasms
Therapeutics
Hypoxia
1 Citation (Scopus)

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: A report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

Zloza, A., Karolina Palucka, A., Coussens, L., Gotwals, P. J., Headley, M. B., Jaffee, E. M., Lund, A., Sharpe, A. H., Sznol, M., Wainwright, D. A., Wong, K. K. & Bosenberg, M. W., Sep 19 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 77.

Research output: Contribution to journalArticle

Allergy and Immunology
Immunotherapy
Education
Neoplasms
Direction compound
2016
13 Citations (Scopus)

208O_PR: CRS-207 with chemotherapy (chemo) in malignant pleural mesothelioma (MPM): Results from a phase 1b trial

Jahan, T., Hassan, R., Alley, E., Kindler, H., Antonia, S., Whiting, C., Coussens, L., Murphy, A. L., Thomas, A. & Brockstedt, D. G., Apr 1 2016, In : Journal of Thoracic Oncology. 11, 4, p. S156

Research output: Contribution to journalArticle

Drug Therapy
Malignant Mesothelioma
16 Citations (Scopus)

AACR Cancer Progress Report 2016

Davidson, N. E., Armstrong, S. A., Coussens, L., Cruz-Correa, M. R., DeBerardinis, R. J., Doroshow, J. H., Foti, M., Hwu, P., Kensler, T. W., Morrow, M., Mulligan, C. G., Pao, W., Platz, E. A., Smith, T. J. & Willman, C. L., Oct 1 2016, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 22, p. S1-S137

Research output: Contribution to journalArticle

Neoplasms

Aid-ing inflammatory carcinogenesis

Lund, A., Apr 20 2016, In : Science Translational Medicine. 8, 335

Research output: Contribution to journalArticle

Carcinogenesis
9 Citations (Scopus)

Amyloid precursor proteins are dynamically trafficked and processed during neuronal development

Ramaker, J. M., Cargill, R. S., Swanson, T. L., Quirindongo, H., Cassar, M., Kretzschmar, D. & Copenhaver, P., Nov 25 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 130.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neurons
Nervous System
Insects
Time-Lapse Imaging
5 Citations (Scopus)

A portal vein injection model to study liver metastasis of breast cancer

Goddard, E. T., Fischer, J. & Schedin, P., Dec 26 2016, In : Journal of Visualized Experiments. 2016, 118, p. 1-10 10 p., e54903.

Research output: Contribution to journalArticle

Portal Vein
Liver
Breast Neoplasms
Neoplasm Metastasis
Injections
4 Citations (Scopus)

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 6
Hepcidins
Iron Overload
Hemochromatosis
Missense Mutation
4 Citations (Scopus)

Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses

Ruszczyk, M., Zirpoli, G., Kumar, S., Bandera, E. V., Bovbjerg, D. H., Jandorf, L., Khoury, T., Hwang, H., Ciupak, G., Pawlish, K., Schedin, P., Masso-Welch, P., Ambrosone, C. B. & Hong, C. C., Feb 1 2016, In : Cancer Causes and Control. 27, 2, p. 183-198 16 p.

Research output: Contribution to journalArticle

Ductal Carcinoma
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Women's Health
150 Citations (Scopus)

Bruton tyrosine kinase–Dependent immune cell cross-talk drives pancreas cancer

Gunderson, A. J., Kaneda, M. M., Tsujikawa, T., Nguyen, A. V., Affara, N. I., Ruffell, B., Gorjestani, S., Liudahl, S. M., Truit, M., Olson, P., Kim, G., Hanahan, D., Tempero, M. A., Sheppard, B., Irving, B., Chang, B. Y., Varner, J. A. & Coussens, L., Mar 1 2016, In : Cancer Discovery. 6, 3, p. 270-285 16 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tyrosine
Pancreas
Adenocarcinoma
Macrophages
30 Citations (Scopus)

COX-2 modulates mammary tumor progression in response to collagen density

Esbona, K., Inman, D., Saha, S., Jeffery, J., Schedin, P., Wilke, L. & Keely, P., Mar 22 2016, In : Breast Cancer Research. 18, 1, 35.

Research output: Contribution to journalArticle

Celecoxib
Cyclooxygenase 2
Collagen
Breast Neoplasms
Neoplasms
23 Citations (Scopus)

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

Cooper, Z. A., Reuben, A., Spencer, C. N., Prieto, P. A., Austin-Breneman, J. L., Jiang, H., Haymaker, C., Gopalakrishnan, V., Tetzlaff, M. T., Frederick, D. T., Sullivan, R. J., Amaria, R. N., Patel, S. P., Hwu, P., Woodman, S. E., Glitza, I. C., Diab, A., Vence, L. M., Rodriguez-Canales, J., Parra, E. R. & 11 others, Wistuba, I. I., Coussens, L., Sharpe, A. H., Flaherty, K. T., Gershenwald, J. E., Chin, L., Davies, M. A., Clise-Dwyer, K., Allison, J. P., Sharma, P. & Wargo, J. A., Mar 3 2016, In : OncoImmunology. 5, 3

Research output: Contribution to journalArticle

Melanoma
Therapeutics
T-Lymphocytes
Pathologic Neovascularization
angiogenesis
neoplasms
Neoplasms
3 Citations (Scopus)

Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development

Green, Y. S., Kwon, S. & Christian, J. L., Jan 1 2016, In : Gene Expression Patterns. 20, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Xenopus
Mesoderm
Breast Neoplasms
Pronephros
261 Citations (Scopus)

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

Zanganeh, S., Hutter, G., Spitler, R., Lenkov, O., Mahmoudi, M., Shaw, A., Pajarinen, J. S., Nejadnik, H., Goodman, S., Moseley, M., Coussens, L. & Daldrup-Link, H. E., Nov 1 2016, In : Nature Nanotechnology. 11, 11, p. 986-994 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
macrophages
Macrophages
Iron oxides
iron oxides
5 Citations (Scopus)

Kif1B interacts with KBP to promote axon elongation by localizing a microtubule regulator to growth cones

Drerup, C. M., Lusk, S. & Nechiporuk, A., Jun 29 2016, In : Journal of Neuroscience. 36, 26, p. 7014-7026 13 p.

Research output: Contribution to journalArticle

Growth Cones
Microtubules
Axons
Carrier Proteins
Stathmin
37 Citations (Scopus)

Lymphatic vessels, inflammation, and immunity in skin cancer

Lund, A., Medler, T. R., Leachman, S. & Coussens, L., Jan 1 2016, In : Cancer Discovery. 6, 1, p. 22-35 14 p.

Research output: Contribution to journalArticle

Lymphatic Vessels
Skin Neoplasms
Immunity
Inflammation
Skin
46 Citations (Scopus)

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Lund, A., Wagner, M., Fankhauser, M., Steinskog, E. S., Broggi, M. A., Spranger, S., Gajewski, T. F., Alitalo, K., Eikesdal, H. P., Wiig, H. & Swartz, M. A., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3389-3402 14 p.

Research output: Contribution to journalArticle

Lymphatic Vessels
Melanoma
Drainage
Immunity
Tumor Microenvironment
14 Citations (Scopus)

Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization

Fornetti, J., Flanders, K. C., Henson, P. M., Tan, A. C., Borges, V. F. & Schedin, P., Feb 1 2016, In : Cell Death and Differentiation. 23, 2, p. 185-196 12 p.

Research output: Contribution to journalArticle

Adherens Junctions
Cytophagocytosis
Transforming Growth Factors
Breast
Epithelial Cells
6 Citations (Scopus)

Manduca contactin regulates amyloid precursor protein-dependent neuronal migration

Ramaker, J. M., Swanson, T. L. & Copenhaver, P., Aug 17 2016, In : Journal of Neuroscience. 36, 33, p. 8757-8775 19 p.

Research output: Contribution to journalArticle

Contactins
Manduca
Amyloid beta-Protein Precursor
Proteins
Nervous System
16 Citations (Scopus)

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Wilson, R. A., Espinosa-Diez, C., Kanner, N., Chatterjee, N., Ruhl, R., Hipfinger, C., Advani, S. J., Li, J., Khan, O. F., Franovic, A., Weis, S. M., Kumar, S., Coussens, L., Anderson, D. G., Chen, C. C., Cheresh, D. A. & Anand, S., Nov 25 2016, In : Nature Communications. 7, 13597.

Research output: Contribution to journalArticle

Tumor Microenvironment
MicroRNAs
Tumors
tumors
Neoplasms
69 Citations (Scopus)

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

Tuschl, K., Meyer, E., Valdivia, L. E., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C. Y., Simpson, M. A., Chong, W. K., Jacques, T. S., Woltjer, R. R., Eaton, S., Gregory, A., Sanford, L., Kara, E., Houlden, H., Cuno, S. M., Prokisch, H., Valletta, L., Tiranti, V. & 20 others, Younis, R., Maher, E. R., Spencer, J., Straatman-Iwanowska, A., Gissen, P., Selim, L. A. M., Pintos-Morell, G., Coroleu-Lletget, W., Mohammad, S. S., Yoganathan, S., Dale, R. C., Thomas, M., Rihel, J., Bodamer, O. A., Enns, C., Hayflick, S., Clayton, P. T., Mills, P. B., Kurian, M. A. & Wilson, S. W., May 27 2016, In : Nature Communications. 7, 11601.

Research output: Contribution to journalArticle

Dystonic Disorders
homeostasis
Parkinsonian Disorders
Manganese
mutations
2 Citations (Scopus)

Myoepithelial cells in lobular carcinoma in situ: Distribution and immunophenotype

Wang, Y., Jindal, S., Martel, M., Wu, Y., Schedin, P. & Troxell, M., Sep 1 2016, In : Human Pathology. 55, p. 126-134 9 p.

Research output: Contribution to journalArticle

Smooth Muscle Myosins
Breast
Myosin Heavy Chains
Staining and Labeling
Basement Membrane
20 Citations (Scopus)

Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver

Zhao, N., Maxson, J., Zhang, R. H., Wahedi, M., Enns, C. & Zhang, A-S., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12322-12335 14 p.

Research output: Contribution to journalArticle

Hepcidins
Liver
Bone Morphogenetic Proteins
Furin
Type I Bone Morphogenetic Protein Receptors
6 Citations (Scopus)

Non-invasive single-cell biomechanical analysis using live-imaging datasets

Pearson, Y. E., Lund, A., Lin, A. W. H., Ng, C. P., Alsuwaidi, A., Azzeh, S., Gater, D. L. & Teo, J. C. M., 2016, In : Journal of Cell Science. 129, 17, p. 3351-3364 14 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Mesenchymal Stromal Cells
Endpoint Determination
T-Lymphocytes
Atomic Force Microscopy
20 Citations (Scopus)

Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments

Goddard, E. T., Hill, R. C., Barrett, A., Betts, C., Guo, Q., Maller, O., Borges, V. F., Hansen, K. C. & Schedin, P., Dec 1 2016, In : International Journal of Biochemistry and Cell Biology. 81, p. 223-232 10 p.

Research output: Contribution to journalArticle

Liver
Proteomics
Extracellular Matrix
Breast
Tissue
14 Citations (Scopus)

Senescence and cancer: An evolving inflammatory paradox

Ruhland, M. K., Coussens, L. & Stewart, S. A., Jan 1 2016, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1865, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

Neoplasms
Biological Phenomena
Phenotype
Wound Healing
Artifacts
1 Citation (Scopus)

Studying Readiness for Clinical Decision Support for Worker Health Using the Rapid Assessment Process and Mixed Methods Interviews

Ash, J., Chase, D., Wiesen, J., Murphy, E. V. & Marovich, S., 2016, In : AMIA ... Annual Symposium proceedings. AMIA Symposium. 2016, p. 285-294 10 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Process Assessment (Health Care)
Interviews
Health
Low Back Pain
6 Citations (Scopus)

STX, a novel membrane estrogen receptor ligand, protects against amyloid-β toxicity

Gray, N. E., Zweig, J. A., Kawamoto, C., Quinn, J. & Copenhaver, P., Mar 15 2016, In : Journal of Alzheimer's Disease. 51, 2, p. 391-403 13 p.

Research output: Contribution to journalArticle

Amyloid
Estrogen Receptors
Mitochondrial Genes
Neuroblastoma
Ligands
231 Citations (Scopus)

The Basis of Oncoimmunology

Palucka, A. K. & Coussens, L., Mar 10 2016, In : Cell. 164, 6, p. 1233-1247 15 p.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Tumors
Neoplasms
Active Immunity
5 Citations (Scopus)

The Importance of the Saphenous Nerve in Ankle Surgery

Eglitis, N., Horn, J. L., Benninger, B. & Nelsen, S., May 1 2016, In : Anesthesia and Analgesia. 122, 5, p. 1704-1706 3 p.

Research output: Contribution to journalArticle

Tibia
Ankle
Periosteum
Ankle Joint
Capsules