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2020

Acidic fibroblast growth factor underlies microenvironmental regulation of myc in pancreatic cancer

Bhattacharyya, S., Oon, C., Kothari, A., Horton, W., Link, J., Sears, R. C. & Sherman, M. H., Aug 3 2020, In : Journal of Experimental Medicine. 217, 8, e20191805.

Research output: Contribution to journalArticle

Open Access

Comparison of Mortality Among Participants of Women's Health Initiative Trials With Screening-Detected Breast Cancers vs Interval Breast Cancers

Irvin, V. L., Zhang, Z., Simon, M. S., Chlebowski, R. T., Luoh, S-W., Shadyab, A. H., Krok-Schoen, J. L., Tabung, F. K., Qi, L., Stefanick, M. L., Schedin, P. & Jindal, S., Jun 1 2020, In : JAMA Network Open. 3, 6, p. e207227

Research output: Contribution to journalArticle

Open Access

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C., Zagorodna, O., Dogruluk, T., Lu, H., Villafane, N., Bhavana, V. H., Moreno, D., Elsea, S. H., Liang, H., Mills, G. B. & Scott, K. L., Apr 2020, In : eLife. 9, e48963.

Research output: Contribution to journalArticle

Open Access

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

Rana, S., Espinosa-Diez, C., Ruhl, R., Chatterjee, N., Hudson, C., Fraile-Bethencourt, E., Agarwal, A., Khou, S., Thomas, C. R. & Anand, S., Dec 1 2020, In : Scientific Reports. 10, 1, 5581.

Research output: Contribution to journalArticle

Open Access

Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload

Wortham, A. M., Goldman, D. C., Chen, J., Fleming, W. H., Zhang, A. S., Enns, C. A. & Peter Guengerich, F., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

In Vivo Removal of N-Terminal Fusion Domains From Recombinant Target Proteins Produced in Nicotiana benthamiana

Islam, M. R., Choi, S., Muthamilselvan, T., Shin, K. & Hwang, I., Apr 8 2020, In : Frontiers in Plant Science. 11, 440.

Research output: Contribution to journalArticle

Open Access

Oligonucleotide conjugated antibodies permit highly multiplexed immunofluorescence for future use in clinical histopathology

Mcmahon, N. P., Jones, J. A., Kwon, S., Chin, K., Nederlof, M. A., Gray, J. W. & Gibbs, S. L., May 1 2020, In : Journal of biomedical optics. 25, 5, 056004.

Research output: Contribution to journalArticle

Open Access

Use of inkjet-printed single cells to quantify intratumoral heterogeneity

Yoon, W. H., Lee, H. R., Kim, S. E., Kim, E., Ku, J. H., Shin, K. & Jung, S., Jul 1 2020, In : Biofabrication. 12, 3, 1 p.

Research output: Contribution to journalArticle

2019

Association Between Postpartum Breast Cancer Diagnosis and Metastasis and the Clinical Features Underlying Risk

Goddard, E. T., Bassale, S., Schedin, T., Jindal, S., Johnston, J., Cabral, E., Latour, E., Lyons, T. R., Mori, M., Schedin, P. J. & Borges, V. F., Jan 4 2019, In : JAMA Network Open. 2, 1, p. e186997

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma

Li, J. P., Zhang, X. M., Zhang, Z., Zheng, L. H., Jindal, S. & Liu, Y. J., May 1 2019, In : Medicine (United States). 98, 18, e15449.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A stromal lysolipid–autotaxin signaling axis promotes pancreatic tumor progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. C. & 2 others, Kamphorst, J. J. & Sherman, M. H., May 2019, In : Cancer discovery. 9, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

Xu, X., Wang, Y., Mojumdar, K., Zhou, Z., Jeong, K. J., Mangala, L. S., Yu, S., Tsang, Y. H., Rodriguez-Aguayo, C., Lu, Y., Lopez-Berestein, G., Sood, A. K., Mills, G. B. & Liang, H., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5343-5356 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M. L., Lewis, C. E., Coussens, L. M., Bardia, A., Jain, R. K., Pollard, J. W. & De Palma, M., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 190-202 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Hassan, R., Alley, E., Kindler, H., Antonia, S., Jahan, T., Honarmand, S., Nair, N., Whiting, C. C., Enstrom, A., Lemmens, E., Tsujikawa, T., Kumar, S., Choe, G., Thomas, A., McDougall, K., Murphy, A. L., Jaffee, E., Coussens, L. M. & Brockstedt, D. G., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5787-5798 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Culture, manipulation, and orthotopic transplantation of mouse bladder tumor organoids

Kim, Y., Lee, J., Kim, S. & Shin, K., Jan 2019, In : Journal of Visualized Experiments. 2020, 155, e60469.

Research output: Contribution to journalArticle

Open Access

Epigenetic regulation of mammalian hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

Kim, S., Kim, Y., Kong, J., Kim, E., Choi, J. H., Yuk, H. D., Lee, H., Kim, H. R., Lee, K. H., Kang, M., Roe, J. S., Moon, K. C., Kim, S., Ku, J. H. & Shin, K., Apr 1 2019, In : eLife. 8, e43024.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Fibroblasts as modulators of local and systemic cancer metabolism

Sanford-Crane, H., Abrego, J. & Sherman, M. H., May 2019, In : Cancers. 11, 5, 619.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development

Song, Y. C., Dohn, T. E., Rydeen, A. B., Nechiporuk, A. V. & Waxman, J. S., May 2019, In : PLoS genetics. 15, 5, e1008165.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Cassetta, L., Fragkogianni, S., Sims, A. H., Swierczak, A., Forrester, L. M., Zhang, H., Soong, D. Y. H., Cotechini, T., Anur, P., Lin, E. Y., Fidanza, A., Lopez-Yrigoyen, M., Millar, M. R., Urman, A., Ai, Z., Spellman, P. T., Hwang, E. S., Dixon, J. M., Wiechmann, L., Coussens, L. M. & 2 others, Smith, H. O. & Pollard, J. W., Apr 15 2019, In : Cancer Cell. 35, 4, p. 588-602.e10

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Late-stage tumor regression after PD-L1 blockade plus a concurrent OX40 agonist

Polesso, F., Weinberg, A. D. & Moran, A., Feb 1 2019, In : Cancer Immunology Research. 7, 2, p. 269-281 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland

Jeong, J., Kim, W., Hens, J., Dann, P., Schedin, P., Friedman, P. A. & Wysolmerski, J. J., Jul 4 2019, In : Endocrinology. 160, 8, p. 1797-1810 14 p., 201900230.

Research output: Contribution to journalArticle

1 Scopus citations

OX40 agonist tumor immunotherapy does not impact regulatory T cell suppressive function

Polesso, F., Sarker, M., Weinberg, A. D., Murray, S. E. & Moran, A. E., Oct 1 2019, In : Journal of Immunology. 203, 7, p. 2011-2019 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer

Reddy, S. M., Reuben, A., Barua, S., Jiang, H., Zhang, S., Wang, L., Gopalakrishnan, V., Hudgens, C. W., Tetzlaff, M. T., Reuben, J. M., Tsujikawa, T., Coussens, L. M., Wani, K., He, Y., Villareal, L., Wood, A., Rao, A., Woodward, W. A., Ueno, N. T., Krishnamurthy, S. & 2 others, Wargo, J. A. & Mittendorf, E. A., Jun 2019, In : Cancer Immunology Research. 7, 6, p. 1025-1035 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Steele, M. M., Churchill, M. J., Breazeale, A. P., Lane, R. S., Nelson, N. A. & Lund, A., Jan 7 2019, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journalArticle

1 Scopus citations

Retrograde Ret signaling controls sensory pioneer axon outgrowth

Tuttle, A., Drerup, C. M., Marra, M., McGraw, H. & Nechiporuk, A., Sep 2 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity

Tsujikawa, T., Thibault, G., Azimi, V., Sivagnanam, S., Banik, G., Means, C., Kawashima, R., Clayburgh, D. R., Gray, J. W., Coussens, L. M. & Chang, Y. H., Apr 2019, In : Cytometry Part A. 95, 4, p. 389-398 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

Fang, Y., McGrail, D. J., Sun, C., Labrie, M., Chen, X., Zhang, D., Ju, Z., Vellano, C. P., Lu, Y., Li, Y., Jeong, K. J., Ding, Z., Liang, J., Wang, S. W., Dai, H., Lee, S., Sahni, N., Mercado-Uribe, I., Kim, T. B., Chen, K. & 7 others, Lin, S. Y., Peng, G., Westin, S. N., Liu, J., O'Connor, M. J., Yap, T. A. & Mills, G. B., Jun 10 2019, In : Cancer Cell. 35, 6, p. 851-867.e7

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
1 Scopus citations

Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status

Means, C., Clayburgh, D. R., Maloney, L., Sauer, D., Taylor, M. H., Shindo, M. L., Coussens, L. M. & Tsujikawa, T., Aug 2019, In : Head and Neck. 41, 8, p. 2636-2646 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Best practices for preventing malfunctions in rule-based clinical decision support alerts and reminders: Results of a Delphi study

Wright, A., Ash, J. S., Aaron, S., Ai, A., Hickman, T. T. T., Wiesen, J. F., Galanter, W., McCoy, A. B., Schreiber, R., Longhurst, C. A. & Sittig, D. F., Oct 2018, In : International Journal of Medical Informatics. 118, p. 78-85 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P. S., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S. A., Fischer, J. M. & 8 others, Jaboin, J., Billingsley, K. G., Lopez, C. D., Burchard, J., Gray, J., Coussens, L. M., Sheppard, B. C. & Wong, M. H., Sep 12 2018, In : Science Advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

43 Scopus citations

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects

Goodman, J. R., Adham, Z. O., Woltjer, R. R., Lund, A. & Iliff, J., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

12 Scopus citations

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

Medler, T. R., Murugan, D., Horton, W., Kumar, S., Cotechini, T., Forsyth, A. M., Leyshock, P., Leitenberger, J. J., Kulesz-Martin, M., Margolin, A., Werb, Z. & Coussens, L., Oct 8 2018, In : Cancer Cell. 34, 4, p. 561-578.e6

Research output: Contribution to journalArticle

27 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

37 Scopus citations

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., Cogdill, A. P., Zhao, L., Hudgens, C. W., Hutchinson, D. S., Manzo, T., Petaccia De Macedo, M., Cotechini, T., Kumar, T., Chen, W. S., Reddy, S. M. & 50 others, Szczepaniak Sloane, R., Galloway-Pena, J., Jiang, H., Chen, P. L., Shpall, E. J., Rezvani, K., Alousi, A. M., Chemaly, R. F., Shelburne, S., Vence, L. M., Okhuysen, P. C., Jensen, V. B., Swennes, A. G., McAllister, F., Marcelo Riquelme Sanchez, E., Zhang, Y., Le Chatelier, E., Zitvogel, L., Pons, N., Austin-Breneman, J. L., Haydu, L. E., Burton, E. M., Gardner, J. M., Sirmans, E., Hu, J., Lazar, A. J., Tsujikawa, T., Diab, A., Tawbi, H., Glitza, I. C., Hwu, W. J., Patel, S. P., Woodman, S. E., Amaria, R. N., Davies, M. A., Gershenwald, J. E., Hwu, P., Lee, J. E., Zhang, J., Coussens, L., Cooper, Z. A., Futreal, P. A., Daniel, C. R., Ajami, N. J., Petrosino, J. F., Tetzlaff, M. T., Sharma, P., Allison, J. P., Jenq, R. R. & Wargo, J. A., Jan 5 2018, In : Science. 359, 6371, p. 97-103 7 p.

Research output: Contribution to journalArticle

823 Scopus citations
7 Scopus citations

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

Lane, R. S., Femel, J., Breazeale, A. P., Loo, C. P., Thibault, G., Kaempf, A., Mori, M., Tsujikawa, T., Chang, Y. H. & Lund, A. W., Dec 1 2018, In : Journal of Experimental Medicine. 215, 12, p. 3057-3074 18 p.

Research output: Contribution to journalArticle

21 Scopus citations

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

Ouyang, X., Barling, A., Lesch, A., Tyner, J., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S., McWeeney, S. & Kulesz-Martin, M., Oct 3 2018, In : Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Integrin CD11b activation drives anti-tumor innate immunity

Schmid, M. C., Khan, S. Q., Kaneda, M. M., Pathria, P., Shepard, R., Louis, T. L., Anand, S., Woo, G., Leem, C., Faridi, M. H., Geraghty, T., Rajagopalan, A., Gupta, S., Ahmed, M., Vazquez-Padron, R. I., Cheresh, D. A., Gupta, V. & Varner, J. A., Dec 1 2018, In : Nature communications. 9, 1, 5379.

Research output: Contribution to journalArticle

19 Scopus citations

Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer

Giles, E. D., Jindal, S., Wellberg, E. A., Schedin, T., Anderson, S. M., Thor, A. D., Edwards, D. P., MacLean, P. S. & Schedin, P., Jun 14 2018, In : Breast Cancer Research. 20, 1, 50.

Research output: Contribution to journalArticle

5 Scopus citations

microRNA-451a regulates colorectal cancer proliferation in response to radiation

Ruhl, R., Rana, S., Kelley, K., Espinosa-Diez, C., Hudson, C., Lanciault, C., Thomas, C. R., Liana Tsikitis, V. & Anand, S., May 3 2018, In : BMC cancer. 18, 1, 517.

Research output: Contribution to journalArticle

13 Scopus citations

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling article

Espinosa-Diez, C., Wilson, R., Chatterjee, N., Hudson, C., Ruhl, R., Hipfinger, C., Helms, E., Khan, O. F., Anderson, D. G. & Anand, S., Jun 1 2018, In : Cell Death and Disease. 9, 6, 632.

Research output: Contribution to journalArticle

6 Scopus citations

Mucosal immunity in the female murine mammary gland

Betts, C. B., Pennock, N. D., Caruso, B. P., Ruffell, B., Borges, V. F. & Schedin, P., Jul 15 2018, In : Journal of Immunology. 201, 2, p. 734-746 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nod2 deficiency augments Th17 responses and exacerbates autoimmune arthritis

Napier, R. J., Lee, E., Vance, E. E., Snow, P. E., Samson, K. A., Dawson, C. E., Moran, A., Stenzel, P., Davey, M., Sakaguchi, S. & Rosenzweig, H., Oct 1 2018, In : Journal of Immunology. 201, 7, p. 1889-1898 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Semaphorin 7A promotes macrophage-mediated lymphatic remodeling during postpartum mammary gland involution and in breast cancer

Elder, A. M., Tamburini, B. A. J., Crump, L. S., Black, S. A., Wessells, V. M., Schedin, P., Borges, V. F. & Lyons, T. R., Nov 15 2018, In : Cancer Research. 78, 22, p. 6473-6485 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

SRC increases MYC mRNA expression in estrogen receptor-positive breast cancer via mRNA stabilization and inhibition of p53 function

Abdullah, C., Korkaya, H., Iizuka, S. & Courtneidge, S. A., Mar 1 2018, In : Molecular and cellular biology. 38, 6, e00463-17.

Research output: Contribution to journalArticle

3 Scopus citations

Systematic Functional Annotation of Somatic Mutations in Cancer

Ng, P. K. S., Li, J., Jeong, K. J., Shao, S., Chen, H., Tsang, Y. H., Sengupta, S., Wang, Z., Bhavana, V. H., Tran, R., Soewito, S., Minussi, D. C., Moreno, D., Kong, K., Dogruluk, T., Lu, H., Gao, J., Tokheim, C., Zhou, D. C., Johnson, A. M. & 20 others, Zeng, J., Ip, C. K. M., Ju, Z., Wester, M., Yu, S., Li, Y., Vellano, C. P., Schultz, N., Karchin, R., Ding, L., Lu, Y., Cheung, L. W. T., Chen, K., Shaw, K. R., Meric-Bernstam, F., Scott, K. L., Yi, S., Sahni, N., Liang, H. & Mills, G. B., Mar 12 2018, In : Cancer Cell. 33, 3, p. 450-462.e10

Research output: Contribution to journalArticle

50 Scopus citations

Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

Saung, M. T., Muth, S., Ding, D., Thomas, D. L., Blair, A. B., Tsujikawa, T., Coussens, L., Jaffee, E. M. & Zheng, L., Nov 13 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 1 p.

Research output: Contribution to journalArticle

8 Scopus citations

The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo

Traeger, L., Enns, C., Krijt, J. & Steinbicker, A. U., Dec 1 2018, In : Communications Biology. 1, 1, 65.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

de Mingo Pulido, Á., Gardner, A., Hiebler, S., Soliman, H., Rugo, H. S., Krummel, M. F., Coussens, L. & Ruffell, B., Jan 8 2018, In : Cancer Cell. 33, 1, p. 60-74.e6

Research output: Contribution to journalArticle

58 Scopus citations