Research Output

2020

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

Bhattacharyya, S., Oon, C., Kothari, A., Horton, W., Link, J., Sears, R. C. & Sherman, M. H., Aug 3 2020, In : The Journal of experimental medicine. 217, 8

Research output: Contribution to journalArticle

Open Access

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C., Zagorodna, O., Dogruluk, T., Lu, H., Villafane, N., Bhavana, V. H., Moreno, D., Elsea, S. H., Liang, H., Mills, G. B. & Scott, K. L., Apr 2020, In : eLife. 9, e48963.

Research output: Contribution to journalArticle

Open Access

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

Rana, S., Espinosa-Diez, C., Ruhl, R., Chatterjee, N., Hudson, C., Fraile-Bethencourt, E., Agarwal, A., Khou, S., Thomas, C. R. & Anand, S., Dec 1 2020, In : Scientific Reports. 10, 1, 5581.

Research output: Contribution to journalArticle

Open Access

Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload

Wortham, A. M., Goldman, D. C., Chen, J., Fleming, W. H., Zhang, A. S., Enns, C. A. & Peter Guengerich, F., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment

Helms, E., Onate, M. K. & Sherman, M. H., May 1 2020, In : Cancer discovery. 10, 5, p. 648-656 9 p.

Research output: Contribution to journalReview article

Fluorescent imaging technologies for in situ measurement of drug target engagement and cell signaling pathways

McMahon, N. P., Solanki, A., Jones, J., Kwon, S., Chang, Y. H., Chin, K., Nederlof, M. A., Gray, J. W. & Gibbs, S. L., Jan 1 2020, Visualizing and Quantifying Drug Distribution in Tissue IV. Chan, K. F. & Evans, C. L. (eds.). SPIE, 112190O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11219).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers

Banik, G., Betts, C. B., Liudahl, S. M., Sivagnanam, S., Kawashima, R., Cotechini, T., Larson, W., Goecks, J., Pai, S. I., Clayburgh, D. R., Tsujikawa, T. & Coussens, L., 2020, Methods in Enzymology. Galluzzi, L. & Rudqvist, N-P. (eds.). Academic Press Inc., p. 1-20 20 p. (Methods in Enzymology; vol. 635).

Research output: Chapter in Book/Report/Conference proceedingChapter

In Vivo Removal of N-Terminal Fusion Domains From Recombinant Target Proteins Produced in Nicotiana benthamiana

Islam, M. R., Choi, S., Muthamilselvan, T., Shin, K. & Hwang, I., Apr 8 2020, In : Frontiers in Plant Science. 11, 440.

Research output: Contribution to journalArticle

Open Access

Melanoma to Vitiligo: The Melanocyte in Biology & Medicine–Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting

Leachman, S. A., Hornyak, T. J., Barsh, G., Bastian, B. C., Brash, D. E., Cleaver, J. E., Cooper, C. D., D'Orazio, J. A., Fujita, M., Holmen, S. L., Indra, A. K., Kraemer, K. H., Le Poole, I. C., Lo, R. S., Lund, A. W., Manga, P., Pavan, W. J., Setaluri, V., Stemwedel, C. E. & Kulesz-Martin, M. F., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 269-274 6 p.

Research output: Contribution to journalShort survey

Oligonucleotide conjugated antibodies permit highly multiplexed immunofluorescence for future use in clinical histopathology

Mcmahon, N. P., Jones, J. A., Kwon, S., Chin, K., Nederlof, M. A., Gray, J. W. & Gibbs, S. L., May 1 2020, In : Journal of biomedical optics. 25, 5, 056004.

Research output: Contribution to journalArticle

Open Access

Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients

Blucher, A. S., Mills, G. B. & Tsang, Y. H., Mar 3 2020, In : Expert Review of Proteomics. 17, 3, p. 187-190 4 p.

Research output: Contribution to journalEditorial

Open Access
2019

Association Between Postpartum Breast Cancer Diagnosis and Metastasis and the Clinical Features Underlying Risk

Goddard, E. T., Bassale, S., Schedin, T., Jindal, S., Johnston, J., Cabral, E., Latour, E., Lyons, T. R., Mori, M., Schedin, P. J. & Borges, V. F., Jan 4 2019, In : JAMA Network Open. 2, 1, p. e186997

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma

Li, J. P., Zhang, X. M., Zhang, Z., Zheng, L. H., Jindal, S. & Liu, Y. J., May 1 2019, In : Medicine. 98, 18, p. e15449

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A stromal lysolipid–autotaxin signaling axis promotes pancreatic tumor progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., Vringer, E., Schug, M., Novo, D., Hwang, R. F., Evans, R. M., Nixon, C., Dorrell, C., Morton, J. P., Norman, J. C., Sears, R. C. & 2 others, Kamphorst, J. J. & Sherman, M. H., May 2019, In : Cancer discovery. 9, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

Xu, X., Wang, Y., Mojumdar, K., Zhou, Z., Jeong, K. J., Mangala, L. S., Yu, S., Tsang, Y. H., Rodriguez-Aguayo, C., Lu, Y., Lopez-Berestein, G., Sood, A. K., Mills, G. B. & Liang, H., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5343-5356 14 p.

Research output: Contribution to journalArticle

Open Access

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M. L., Lewis, C. E., Coussens, L. M., Bardia, A., Jain, R. K., Pollard, J. W. & De Palma, M., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 190-202 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Hassan, R., Alley, E., Kindler, H., Antonia, S., Jahan, T., Honarmand, S., Nair, N., Whiting, C. C., Enstrom, A., Lemmens, E., Tsujikawa, T., Kumar, S., Choe, G., Thomas, A., McDougall, K., Murphy, A. L., Jaffee, E., Coussens, L. M. & Brockstedt, D. G., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5787-5798 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Culture, manipulation, and orthotopic transplantation of mouse bladder tumor organoids

Kim, Y., Lee, J., Kim, S. & Shin, K., Jan 2019, In : Journal of Visualized Experiments. 2020, 155, e60469.

Research output: Contribution to journalArticle

Open Access

Editorial: Regulation of Immune Function by the Lymphatic Vasculature

Tamburini, B. A. J., Padera, T. P. & Lund, A. W., Nov 5 2019, In : Frontiers in immunology. 10, 2597.

Research output: Contribution to journalEditorial

Open Access

Epigenetic regulation of mammalian hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

Kim, S., Kim, Y., Kong, J., Kim, E., Choi, J. H., Yuk, H. D., Lee, H., Kim, H. R., Lee, K. H., Kang, M., Roe, J. S., Moon, K. C., Kim, S., Ku, J. H. & Shin, K., Apr 1 2019, In : eLife. 8, e43024.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Fibroblasts as modulators of local and systemic cancer metabolism

Sanford-Crane, H., Abrego, J. & Sherman, M., May 1 2019, In : Cancers. 11, 5, 619.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development

Song, Y. C., Dohn, T. E., Rydeen, A. B., Nechiporuk, A. & Waxman, J. S., May 1 2019, In : PLoS genetics. 15, 5, e1008165.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Cassetta, L., Fragkogianni, S., Sims, A. H., Swierczak, A., Forrester, L. M., Zhang, H., Soong, D. Y. H., Cotechini, T., Anur, P., Lin, E. Y., Fidanza, A., Lopez-Yrigoyen, M., Millar, M. R., Urman, A., Ai, Z., Spellman, P. T., Hwang, E. S., Dixon, J. M., Wiechmann, L., Coussens, L. M. & 2 others, Smith, H. O. & Pollard, J. W., Apr 15 2019, In : Cancer Cell. 35, 4, p. 588-602.e10

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Late-stage tumor regression after PD-L1 blockade plus a concurrent OX40 agonist

Polesso, F., Weinberg, A. D. & Moran, A., Feb 1 2019, In : Cancer Immunology Research. 7, 2, p. 269-281 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Macrophages and Metabolism in the Tumor Microenvironment

Vitale, I., Manic, G., Coussens, L. M., Kroemer, G. & Galluzzi, L., Jul 2 2019, In : Cell Metabolism. 30, 1, p. 36-50 15 p.

Research output: Contribution to journalReview article

21 Scopus citations

NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland

Jeong, J., Kim, W., Hens, J., Dann, P., Schedin, P., Friedman, P. A. & Wysolmerski, J. J., Jul 4 2019, In : Endocrinology. 160, 8, p. 1797-1810 14 p., 201900230.

Research output: Contribution to journalArticle

1 Scopus citations

OX40 agonist tumor immunotherapy does not impact regulatory T cell suppressive function

Polesso, F., Sarker, M., Weinberg, A. D., Murray, S. E. & Moran, A. E., Oct 1 2019, In : Journal of Immunology. 203, 7, p. 2011-2019 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Poor response to neoadjuvant chemotherapy correlates with mast cell infiltration in inflammatory breast cancer

Reddy, S. M., Reuben, A., Barua, S., Jiang, H., Zhang, S., Wang, L., Gopalakrishnan, V., Hudgens, C. W., Tetzlaff, M. T., Reuben, J. M., Tsujikawa, T., Coussens, L. M., Wani, K., He, Y., Villareal, L., Wood, A., Rao, A., Woodward, W. A., Ueno, N. T., Krishnamurthy, S. & 2 others, Wargo, J. A. & Mittendorf, E. A., Jun 2019, In : Cancer Immunology Research. 7, 6, p. 1025-1035 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Steele, M. M., Churchill, M. J., Breazeale, A. P., Lane, R. S., Nelson, N. A. & Lund, A., Jan 7 2019, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journalArticle

1 Scopus citations

Retrograde Ret signaling controls sensory pioneer axon outgrowth

Tuttle, A., Drerup, C. M., Marra, M., McGraw, H. & Nechiporuk, A., Sep 2 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity

Tsujikawa, T., Thibault, G., Azimi, V., Sivagnanam, S., Banik, G., Means, C., Kawashima, R., Clayburgh, D. R., Gray, J. W., Coussens, L. M. & Chang, Y. H., Apr 2019, In : Cytometry Part A. 95, 4, p. 389-398 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

Fang, Y., McGrail, D. J., Sun, C., Labrie, M., Chen, X., Zhang, D., Ju, Z., Vellano, C. P., Lu, Y., Li, Y., Jeong, K. J., Ding, Z., Liang, J., Wang, S. W., Dai, H., Lee, S., Sahni, N., Mercado-Uribe, I., Kim, T. B., Chen, K. & 7 others, Lin, S. Y., Peng, G., Westin, S. N., Liu, J., O'Connor, M. J., Yap, T. A. & Mills, G. B., Jun 10 2019, In : Cancer Cell. 35, 6, p. 851-867.e7

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

The Biophysics of Lymphatic Transport: Engineering Tools and Immunological Consequences

O'Melia, M. J., Lund, A. W. & Thomas, S. N., Dec 20 2019, In : iScience. 22, p. 28-43 16 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Toward a comprehensive view of cancer immune responsiveness: A synopsis from the SITC workshop

Bedognetti, D., Ceccarelli, M., Galluzzi, L., Lu, R., Palucka, K., Samayoa, J., Spranger, S., Warren, S., Wong, K. K., Ziv, E., Chowell, D., Coussens, L. M., De Carvalho, D. D., Denardo, D. G., Galon, J., Kaufman, H. L., Kirchhoff, T., Lotze, M. T., Luke, J. J., Minn, A. J. & 34 others, Politi, K., Shultz, L. D., Simon, R., Thórsson, V., Weidhaas, J. B., Ascierto, M. L., Ascierto, P. A., Barnes, J. M., Barsan, V., Bommareddy, P. K., Bot, A., Church, S. E., Ciliberto, G., De Maria, A., Draganov, D., Ho, W. S., McGee, H. M., Monette, A., Murphy, J. F., Nisticò, P., Park, W., Patel, M., Quigley, M., Radvanyi, L., Raftopoulos, H., Rudqvist, N. P., Snyder, A., Sweis, R. F., Valpione, S., Butterfield, L. H., Disis, M. L., Fox, B. A., Cesano, A. & Marincola, F. M., May 22 2019, In : Journal for immunotherapy of cancer. 7, 1, 131.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status

Means, C., Clayburgh, D. R., Maloney, L., Sauer, D., Taylor, M. H., Shindo, M. L., Coussens, L. M. & Tsujikawa, T., Aug 2019, In : Head and Neck. 41, 8, p. 2636-2646 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

A long sought after "receptor" for ERFE?

Zhang, A-S. & Enns, C., Oct 4 2018, In : Blood. 132, 14, p. 1463-1464 2 p.

Research output: Contribution to journalReview article

1 Scopus citations

A method for quantification of calponin expression in myoepithelial cells in immunohistochemical images of ductal carcinoma in situ

Gray, E., Mitchell, E., Jindal, S., Schedin, P. & Chang, Y. H., May 23 2018, 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018. IEEE Computer Society, Vol. 2018-April. p. 796-799 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

B cells as biomarkers: Predicting immune checkpoint therapy adverse events

Liudahl, S. M. & Coussens, L., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 577-579 3 p.

Research output: Contribution to journalReview article

9 Scopus citations

Best practices for preventing malfunctions in rule-based clinical decision support alerts and reminders: Results of a Delphi study

Wright, A., Ash, J. S., Aaron, S., Ai, A., Hickman, T. T. T., Wiesen, J. F., Galanter, W., McCoy, A. B., Schreiber, R., Longhurst, C. A. & Sittig, D. F., Oct 2018, In : International Journal of Medical Informatics. 118, p. 78-85 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S., Fischer, J. & 8 others, Jaboin, J., Billingsley, K., Lopez, C., Burchard, J., Gray, J., Coussens, L., Sheppard, B. & Wong, M., Sep 12 2018, In : Science advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

37 Scopus citations

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects

Goodman, J. R., Adham, Z. O., Woltjer, R. R., Lund, A. & Iliff, J., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

10 Scopus citations

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

Medler, T. R., Murugan, D., Horton, W., Kumar, S., Cotechini, T., Forsyth, A. M., Leyshock, P., Leitenberger, J. J., Kulesz-Martin, M., Margolin, A., Werb, Z. & Coussens, L., Oct 8 2018, In : Cancer Cell. 34, 4, p. 561-578.e6

Research output: Contribution to journalArticle

25 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

31 Scopus citations

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., Cogdill, A. P., Zhao, L., Hudgens, C. W., Hutchinson, D. S., Manzo, T., Petaccia De Macedo, M., Cotechini, T., Kumar, T., Chen, W. S., Reddy, S. M. & 50 others, Szczepaniak Sloane, R., Galloway-Pena, J., Jiang, H., Chen, P. L., Shpall, E. J., Rezvani, K., Alousi, A. M., Chemaly, R. F., Shelburne, S., Vence, L. M., Okhuysen, P. C., Jensen, V. B., Swennes, A. G., McAllister, F., Marcelo Riquelme Sanchez, E., Zhang, Y., Le Chatelier, E., Zitvogel, L., Pons, N., Austin-Breneman, J. L., Haydu, L. E., Burton, E. M., Gardner, J. M., Sirmans, E., Hu, J., Lazar, A. J., Tsujikawa, T., Diab, A., Tawbi, H., Glitza, I. C., Hwu, W. J., Patel, S. P., Woodman, S. E., Amaria, R. N., Davies, M. A., Gershenwald, J. E., Hwu, P., Lee, J. E., Zhang, J., Coussens, L., Cooper, Z. A., Futreal, P. A., Daniel, C. R., Ajami, N. J., Petrosino, J. F., Tetzlaff, M. T., Sharma, P., Allison, J. P., Jenq, R. R. & Wargo, J. A., Jan 5 2018, In : Science. 359, 6371, p. 97-103 7 p.

Research output: Contribution to journalArticle

742 Scopus citations
4 Scopus citations

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

Lane, R. S., Femel, J., Breazeale, A. P., Loo, C. P., Thibault, G., Kaempf, A., Mori, M., Tsujikawa, T., Chang, Y. H. & Lund, A. W., Dec 1 2018, In : Journal of Experimental Medicine. 215, 12, p. 3057-3074 18 p.

Research output: Contribution to journalArticle

19 Scopus citations

Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models

Ouyang, X., Barling, A., Lesch, A., Tyner, J., Choonoo, G., Zheng, C., Jeng, S., West, T. M., Clayburgh, D., Courtneidge, S., McWeeney, S. & Kulesz-Martin, M., Oct 3 2018, In : Cancer Biology and Therapy. 19, 10, p. 921-933 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Integrin CD11b activation drives anti-tumor innate immunity

Schmid, M. C., Khan, S. Q., Kaneda, M. M., Pathria, P., Shepard, R., Louis, T. L., Anand, S., Woo, G., Leem, C., Faridi, M. H., Geraghty, T., Rajagopalan, A., Gupta, S., Ahmed, M., Vazquez-Padron, R. I., Cheresh, D. A., Gupta, V. & Varner, J. A., Dec 1 2018, In : Nature communications. 9, 1, 5379.

Research output: Contribution to journalArticle

15 Scopus citations