Research Output 1978 2020

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2013
25 Citations (Scopus)

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

Aslan, J., Baker, S. M., Loren, C. P., Haley, K., Itakura, A., Pang, J., Greenberg, D. L., David, L., Manser, E., Chernoff, J. & McCarty, O., Sep 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 5

Research output: Contribution to journalArticle

p21-Activated Kinases
rho GTP-Binding Proteins
Platelet Activation
Thrombin
Blood Platelets
30 Citations (Scopus)

The role of technology and engineering models in transforming healthcare

Pavel, M., Jimison, H. B., Wactlar, H. D., Hayes, T. L., Barkis, W., Skapik, J. & Kaye, J., 2013, In : IEEE Reviews in Biomedical Engineering. 6, p. 156-177 22 p., 6490450.

Research output: Contribution to journalArticle

Health
Information technology
Biomedical engineering
Mobile computing
Learning systems
21 Citations (Scopus)

Topical dual-stain difference imaging for rapid intra-operative tumor identification in fresh specimens

Davis, S. C., Gibbs, S., Gunn, J. R. & Pogue, B. W., Dec 1 2013, In : Optics Letters. 38, 23, p. 5184-5187 4 p.

Research output: Contribution to journalArticle

tumors
surgery
margins
biomarkers
breast
17 Citations (Scopus)

Treatment of severe hand impairment following stroke by combining assisted movement, muscle vibration, and biofeedback

Cordo, P., Wolf, S., Lou, J. S., Bogey, R., Stevenson, M., Hayes, J. & Roth, E., Dec 2013, In : Journal of Neurologic Physical Therapy. 37, 4, p. 194-203 10 p.

Research output: Contribution to journalArticle

Vibration
Hand
Stroke
Muscles
Upper Extremity
2012
135 Citations (Scopus)

A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma

Collisson, E. A., Trejo, C. L., Silva, J. M., Gu, S., Korkola, J., Heiser, L., Charles, R. P., Rabinovich, B. A., Hann, B., Dankort, D., Spellman, P., Phillips, W. A., Gray, J. & McMahon, M., Aug 2012, In : Cancer Discovery. 2, 8, p. 685-693 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Maintenance
Cell Line
Mutation
1-Phosphatidylinositol 4-Kinase
10 Citations (Scopus)

A low-dimensional deformation model for cancer cells in flow

Lee, A. M., Berny-Lang, M. A., Liao, S., Kanso, E., Kuhn, P., McCarty, O. & Newton, P. K., Aug 16 2012, In : Physics of Fluids. 24, 8, 081903.

Research output: Contribution to journalArticle

cancer
cells
multiple docking adapters
shear
fluids
6 Citations (Scopus)

Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

Heeb, M. J., Marzec, U., Gruber, A. & Hanson, S. R., Apr 2012, In : Thrombosis and Haemostasis. 107, 4, p. 690-698 9 p.

Research output: Contribution to journalArticle

Papio
Protein S
Protein C
Thrombosis
Blood Platelets
1 Citation (Scopus)

Approximating distributions in stochastic learning

Leen, T. K., Friel, R. & Nielsen, D., Aug 2012, In : Neural Networks. 32, p. 219-228 10 p.

Research output: Contribution to journalArticle

Fokker Planck equation
Learning
Markov Chains
Plasticity
Learning systems
16 Citations (Scopus)

ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells

Ordinario, E., Han, H. J., Furuta, S., Heiser, L., Jakkula, L. R., Rodier, F., Spellman, P., Campisi, J., Gray, J., Bissell, M. J., Kohwi, Y. & Kohwi-Shigematsu, T., Dec 10 2012, In : PLoS One. 7, 12, e51786.

Research output: Contribution to journalArticle

Automatic teller machines
breasts
Breast
epithelial cells
Epithelial Cells
62 Citations (Scopus)

Bayesian Inference of Signaling Network Topology in a Cancer Cell Line

Hill, S. M., Lu, Y., Molina, J., Heiser, L., Spellman, P., Speed, T. P., Gray, J., Mills, G. & Mukherjee, S., Nov 2012, In : Bioinformatics. 28, 21, p. 2804-2810 7 p.

Research output: Contribution to journalArticle

Bayesian inference
Network Topology
Cancer
Cells
Topology
13 Citations (Scopus)

Beyond novelty detection: Incongruent events, when general and specific classifiers disagree

Weinshall, D., Zweig, A., Hermansky, H., Kombrink, S., Ohl, F. W., Anemüller, J., Bach, J. H., Van Gool, L., Nater, F., Pajdla, T., Havlena, M. & Pavel, M., 2012, In : IEEE Transactions on Pattern Analysis and Machine Intelligence. 34, 10, p. 1886-1901 16 p., 6122029.

Research output: Contribution to journalArticle

Novelty Detection
Labels
Classifiers
Classifier
Speech recognition
32 Citations (Scopus)

Biomechanics of early cardiac development

Goenezen, S., Rennie, M. Y. & Rugonyi, S., Nov 2012, In : Biomechanics and Modeling in Mechanobiology. 11, 8, p. 1187-1204 18 p.

Research output: Contribution to journalArticle

Biomechanics
Hemodynamics
Biomechanical Phenomena
Cardiac
Imaging techniques
42 Citations (Scopus)

Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modeling

Liu, A., Yin, X., Shi, L., Li, P., Thornburg, K., Wang, R. & Rugonyi, S., Jul 23 2012, In : PLoS One. 7, 7, e40869.

Research output: Contribution to journalArticle

Biomechanics
Optical tomography
tomography
Optical Coherence Tomography
Biomechanical Phenomena
191 Citations (Scopus)

Chemotherapy response and recurrence-free survival in Neoadjuvant breast cancer depends on biomarker profiles: Results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)

Esserman, L. J., Berry, D. A., Cheang, M. C. U., Yau, C., Perou, C. M., Carey, L., De Michele, A., Gray, J., Conway-Dorsey, K., Lenburg, M. E., Buxton, M. B., Davis, S. E., Van't Veer, L. J., Hudis, C., Chin, K-Y., Wolf, D., Krontiras, H., Montgomery, L., Tripathy, D., Lehman, C. & 14 others, Liu, M. C., Olopade, O. I., Rugo, H. S., Carpenter, J. T., Livasy, C., Dressler, L., Chhieng, D., Singh, B., Mies, C., Rabban, J., Chen, Y. Y., Giri, D., Au, A. & Hylton, N., Apr 2012, In : Breast Cancer Research and Treatment. 132, 3, p. 1049-1062 14 p.

Research output: Contribution to journalArticle

Biomarkers
Breast Neoplasms
Recurrence
Drug Therapy
Survival
44 Citations (Scopus)

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

Daemen, A., Wolf, D. M., Korkola, J., Griffith, O. L., Frankum, J. R., Brough, R., Jakkula, L. R., Wang, N. J., Natrajan, R., Reis-Filho, J. S., Lord, C. J., Ashworth, A., Spellman, P., Gray, J. & Van'T Veer, L. J., Sep 2012, In : Breast Cancer Research and Treatment. 135, 2, p. 505-517 13 p.

Research output: Contribution to journalArticle

DNA Repair
Cell Line
Genes
Breast Neoplasms
BRCA1 Gene
11 Citations (Scopus)

Development and evaluation of a portable audiometer for high-frequency screening of hearing loss from ototoxicity in homes/clinics

Jacobs, P., Silaski, G., Wilmington, D., Gordon, S., Helt, W., McMillan, G., Fausti, S. A. & Dille, M., 2012, In : IEEE Transactions on Biomedical Engineering. 59, 12 PART2, p. 3097-3103 7 p., 6237516.

Research output: Contribution to journalArticle

Audiometers
Audition
Screening
Oncology
Drug dosage
17 Citations (Scopus)

Development of a label-free imaging technique for the quantification of thrombus formation

Baker, S. M., Phillips, K. G. & McCarty, O., Dec 2012, In : Cellular and Molecular Bioengineering. 5, 4, p. 488-492 5 p.

Research output: Contribution to journalArticle

Platelets
Quantification
Labels
Thrombosis
Imaging
12 Citations (Scopus)

Development of coagulation factor probes for the identification of procoagulant circulating tumor cells

Tormoen, G. W., Cianchetti, F. A., Bock, P. E. & McCarty, O., 2012, In : Frontiers in Oncology. 2 SEP, Article 110.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Blood Coagulation Factors
Neoplasms
Cell Line
Factor VIIa
21 Citations (Scopus)

Do circulating tumor cells play a role in coagulation and thrombosis?

Tormoen, G. W., Haley, K., Levine, R. L. & McCarty, O., 2012, In : Frontiers in Oncology. 2 SEP, Article 115.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Thrombosis
Neoplasms
Anticoagulants
Thrombophilia
17 Citations (Scopus)

Elevated levels of proliferating and recently migrated tumor-associated macrophages confer increased aggressiveness and worse outcomes in breast cancer

Mukhtar, R. A., Moore, A. P., Tandon, V. J., Nseyo, O., Twomey, P., Adisa, C. A., Eleweke, N., Au, A., Baehner, F. L., Moore, D. H., McGrath, M. S., Olopade, O. I., Gray, J., Campbell, M. J. & Esserman, L. J., Nov 2012, In : Annals of Surgical Oncology. 19, 12, p. 3979-3986 8 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Macrophages
Breast Neoplasms
Neoplasms
Hormones
68 Citations (Scopus)

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Wen, X., Jacques, S., Tuchin, V. V. & Zhu, D., Jun 2012, In : Journal of Biomedical Optics. 17, 6, 066022.

Research output: Contribution to journalArticle

clearing
Optical tomography
Skin
tomography
Imaging techniques
22 Citations (Scopus)

Extracellular matrix production and regulation in micropatterned endothelial cells

Anderson, D. E. J. & Hinds, M., Oct 12 2012, In : Biochemical and Biophysical Research Communications. 427, 1, p. 159-164 6 p.

Research output: Contribution to journalArticle

Endothelial cells
Extracellular Matrix
Collagen
Fibronectins
Endothelial Cells
11 Citations (Scopus)
embryos
Optical tomography
tomography
Tissue
Imaging techniques
19 Citations (Scopus)

Factor xi-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

Luo, D., Szaba, F. M., Kummer, L. W., Johnson, L. L., Tucker, E., Gruber, A., Gailani, D. & Smiley, S. T., Jan 2012, In : Infection and Immunity. 80, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Listeriosis
Factor XI
Fibrin
Listeria monocytogenes
Inflammation
44 Citations (Scopus)

Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry

Subhash, H. M., Nguyen-Huynh, A., Wang, R. K., Jacques, S., Choudhury, N. & Nuttall, A., Jun 2012, In : Journal of Biomedical Optics. 17, 6, 060505.

Research output: Contribution to journalArticle

middle ear
Optical tomography
Demonstrations
tomography
Acoustics
28 Citations (Scopus)

Fluid shear stress alters the hemostatic properties of endothelial outgrowth cells

Ensley, A. E., Nerem, R. M., Anderson, D. E. J., Hanson, S. R. & Hinds, M., Jan 1 2012, In : Tissue Engineering - Part A. 18, 1-2, p. 127-136 10 p.

Research output: Contribution to journalArticle

Hemostatics
Shear stress
Endothelial Cells
Fluids
Proteins
15 Citations (Scopus)

Genetic Differences in Transcript Responses to Low-Dose Ionizing Radiation Identify Tissue Functions Associated with Breast Cancer Susceptibility

Snijders, A. M., Marchetti, F., Bhatnagar, S., Duru, N., Han, J., Hu, Z., Mao, J. H., Gray, J. & Wyrobek, A. J., Oct 15 2012, In : PLoS One. 7, 10, e45394.

Research output: Contribution to journalArticle

Ionizing radiation
Ionizing Radiation
ionizing radiation
breast neoplasms
Dosimetry
12 Citations (Scopus)

Genomic aberrations in normal tissue adjacent to HER2-amplified breast cancers: Field cancerization or contaminating tumor cells?

Sadanandam, A., Lal, A., Benz, S. C., Eppenberger-Castori, S., Scott, G., Gray, J., Spellman, P., Waldman, F. & Benz, C. C., Dec 2012, In : Breast Cancer Research and Treatment. 136, 3, p. 693-703 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Breast
Segmental Mastectomy
erbB-2 Genes
32 Citations (Scopus)

Genomics: The breast cancer landscape

Gray, J. & Druker, B., Jun 21 2012, In : Nature. 486, 7403, p. 328-329 2 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Neoplastic Cell Transformation
DNA Copy Number Variations
Genetic Translocation
Aromatase Inhibitors
33 Citations (Scopus)

Goniometric measurements of thick tissue using Monte Carlo simulations to obtain the single scattering anisotropy coefficient

Hall, G., Jacques, S., Eliceiri, K. W. & Campagnola, P. J., Nov 1 2012, In : Biomedical Optics Express. 3, 11, p. 2707-2719 13 p.

Research output: Contribution to journalArticle

Anisotropy
anisotropy
coefficients
scattering
simulation
29 Citations (Scopus)

Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis

Winkler, C. W., Foster, S. C., Matsumoto, S., Preston, M. A., Xing, R., Bebo, B. F., Banine, F., Berny-Lang, M. A., Itakura, A., McCarty, O. & Sherman, L. L., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33237-33251 15 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Lymphocytes
Endothelial cells
Neurology
Hyaluronic Acid
59 Citations (Scopus)

Identification of PADI2 as a potential breast cancer biomarker and therapeutic target

McElwee, J. L., Mohanan, S., Griffith, O. L., Breuer, H. C., Anguish, L. J., Cherrington, B. D., Palmer, A. M., Howe, L. R., Subramanian, V., Causey, C. P., Thompson, P. R., Gray, J. & Coonrod, S. A., Oct 30 2012, In : BMC Cancer. 12, 500.

Research output: Contribution to journalArticle

Tumor Biomarkers
Breast Neoplasms
Cell Line
cdc Genes
Neoplasms
5 Citations (Scopus)

Improved deposition and deprotection of silane tethered 3,4 hydroxypyridinone (HOPO) ligands on functionalized nanoporous silica

Davidson, J. D., Wiacek, R. J., Burton, S., Li, X. S., Fryxell, G. E., Addleman, R. S., Yantasee, W., Sangvanich, T. & Pattamakomsan, K., Apr 2012, In : Inorganic Chemistry Communications. 18, p. 92-96 5 p.

Research output: Contribution to journalArticle

Silanes
silanes
Silicon Dioxide
Monolayers
Blood
7 Citations (Scopus)

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Jacobs, P., Konrad-Martin, D., McMillan, G. P., McDermott, D., Fausti, S. A., Kagen, D. & Wan, E. A., Feb 2012, In : Journal of the Acoustical Society of America. 131, 2, p. 1296-1306 11 p.

Research output: Contribution to journalArticle

hyperglycemia
reflexes
glucose
stimuli
sugars
49 Citations (Scopus)

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Tucker, E., Verbout, N. G., Leung, P. Y., Hurst, S., McCarty, O., Gailani, D. & Gruber, A., May 17 2012, In : Blood. 119, 20, p. 4762-4768 7 p.

Research output: Contribution to journalArticle

Factor XI
Sepsis
Chemical activation
Inflammation
Coagulation
29 Citations (Scopus)

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

Leung, P. Y., Hurst, S., Berny-Lang, M. A., Verbout, N. G., Gailani, D., Tucker, E., Wang, R. K., McCarty, O. & Gruber, A., Sep 2012, In : Translational Stroke Research. 3, 3, p. 381-389 9 p.

Research output: Contribution to journalArticle

Factor XI
Factor XII
Stroke
Hemostasis
Antibodies
14 Citations (Scopus)

Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology

Hill, S. M., Neve, R. M., Bayani, N., Kuo, W. L., Ziyad, S., Spellman, P., Gray, J. & Mukherjee, S., May 11 2012, In : BMC Bioinformatics. 13, 1, 94.

Research output: Contribution to journalArticle

Empirical Bayes
Variable Selection
Biology
Cancer
Specifications
13 Citations (Scopus)
Optical tomography
blood flow
strain rate
Strain rate
Blood
33 Citations (Scopus)

In vivo outer hair cell length changes expose the active process in the cochlea

Zha, D., Chen, F., Ramamoorthy, S., Fridberger, A., Choudhury, N., Jacques, S., Wang, R. K. & Nuttall, A., Apr 9 2012, In : PLoS One. 7, 4, e32757.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Cochlea
hairs
Amplification
Cells
40 Citations (Scopus)

Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers

Drake, P. M., Schilling, B., Niles, R. K., Prakobphol, A., Li, B., Jung, K., Cho, W., Braten, M., Inerowicz, H. D., Williams, K., Albertolle, M., Held, J. M., Iacovides, D., Sorensen, D. J., Griffith, O. L., Johansen, E., Zawadzka, A. M., Cusack, M. P., Allen, S., Gormley, M. & 6 others, Hall, S. C., Witkowska, H. E., Gray, J., Regnier, F., Gibson, B. W. & Fisher, S. J., Apr 6 2012, In : Journal of Proteome Research. 11, 4, p. 2508-2520 13 p.

Research output: Contribution to journalArticle

Workflow
Biomarkers
Chromatography
Lectins
Mass spectrometry
26 Citations (Scopus)

Loss of cell-surface laminin anchoring promotes tumor growth and is associated with poor clinical outcomes

Akhavan, A., Griffith, O. L., Soroceanu, L., Leonoudakis, D., Luciani-Torres, M. G., Daemen, A., Gray, J. & Muschler, J., May 15 2012, In : Cancer Research. 72, 10, p. 2578-2588 11 p.

Research output: Contribution to journalArticle

Laminin
Growth
Neoplasms
Brain Neoplasms
Disease Progression
79 Citations (Scopus)

Measurement of Single Cell Refractive Index, Dry Mass, Volume, and Density Using a Transillumination Microscope

Phillips, K. G., Jacques, S. & McCarty, O., Sep 13 2012, In : Physical Review Letters. 109, 11, 118105.

Research output: Contribution to journalArticle

microscopes
refractivity
optical microscopes
cells
dimensional measurement
83 Citations (Scopus)

Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials

McKenna, K., Hinds, M., Sarao, R. C., Wu, P. C., Maslen, C., Glanville, R. W., Babcock, D. & Gregory, K., Jan 2012, In : Acta Biomaterialia. 8, 1, p. 225-233 9 p.

Research output: Contribution to journalArticle

Tropoelastin
Biocompatible Materials
Biomaterials
Grafts
Blood Vessels
13 Citations (Scopus)

Modeling and simulation of procoagulant circulating tumor cells in flow

Lee, A. M., Tormoen, G. W., Kanso, E., McCarty, O. & Newton, P. K., 2012, In : Frontiers in Oncology. 2 SEP, Article 108.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Thrombin
Blood Coagulation Factors
Enzymes
Thrombophilia
30 Citations (Scopus)

Omics and therapy - A basis for precision medicine

Garay, J. P. & Gray, J., Apr 2012, In : Molecular Oncology. 6, 2, p. 128-139 12 p.

Research output: Contribution to journalArticle

Precision Medicine
Genome
Neoplasms
Disease Management
Therapeutics
19 Citations (Scopus)

Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography

Subhash, H. M., Xie, H., Smith, J. W. & McCarty, O., Mar 1 2012, In : Optics Letters. 37, 5, p. 981-983 3 p.

Research output: Contribution to journalArticle

tomography
nanoparticles
acids
interferometry
sensitivity
56 Citations (Scopus)

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient

Phillips, K. G., Velasco, C. R., Li, J., Kolatkar, A., Luttgen, M., Bethel, K., Duggan, B., Kuhn, P. & McCarty, O., 2012, In : Frontiers in Oncology. 2 JUL, Article 72.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Ovarian Neoplasms
Leukocytes
Interference Microscopy
Neoplasms
4 Citations (Scopus)

Optimization-based inference for temporally evolving networks with applications in biology

Chang, Y. H., Gray, J. & Tomlin, C., Dec 1 2012, In : Journal of Computational Biology. 19, 12, p. 1307-1323 17 p.

Research output: Contribution to journalArticle

Genetic Network
Biological Networks
Biology
Research Design
Costs and Cost Analysis
50 Citations (Scopus)

Parametric imaging of the local attenuation coefficient in human axillary lymph nodes assessed using optical coherence tomography

Scolaro, L., McLaughlin, R. A., Klyen, B. R., Wood, B. A., Robbins, P. D., Saunders, C. M., Jacques, S. & Sampson, D. D., Feb 1 2012, In : Biomedical Optics Express. 3, 2, p. 366-379 14 p.

Research output: Contribution to journalArticle

lymphatic system
Optical Coherence Tomography
attenuation coefficients
tomography
Lymph Nodes
249 Citations (Scopus)

Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: Results from the I-SPY 1 TRIAL - CALGB 150007/150012, ACRIN 6657

Esserman, L. J., Berry, D. A., DeMichele, A., Carey, L., Davis, S. E., Buxton, M., Hudis, C., Gray, J., Perou, C., Yau, C., Livasy, C., Krontiras, H., Montgomery, L., Tripathy, D., Lehman, C., Liu, M. C., Olopade, O. I., Rugo, H. S., Carpenter, J. T., Dressler, L. & 8 others, Chhieng, D., Singh, B., Mies, C., Rabban, J., Chen, Y. Y., Giri, D., Van't Veer, L. & Hylton, N., Sep 10 2012, In : Journal of Clinical Oncology. 30, 26, p. 3242-3249 8 p.

Research output: Contribution to journalArticle

Recurrence
Survival
Hormones
Neoplasms
Breast Neoplasms