Research Output 1978 2019

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2019

3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy

França, C. M., Riggers, R., Muschler, J., Widbiller, M., Lococo, P. M., Diogenes, A. & Bertassoni, L., Dec 1 2019, In : Scientific Reports. 9, 1, 10860.

Research output: Contribution to journalArticle

Open Access
Dental Pulp
Acrylamide
Hydrogel
Blood Vessels
Microscopy

Adaptive tuning of basal and bolus insulin to reduce postprandial hypoglycemia in a hybrid artificial pancreas

Resalat, N., El Youssef, J., Reddy, R., Castle, J. & Jacobs, P., Aug 1 2019, In : Journal of Process Control. 80, p. 247-254 8 p.

Research output: Contribution to journalArticle

Insulin
Adaptive Learning
Tuning
Diabetes
Medical problems
2 Citations (Scopus)

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivanov, I., Matafonov, A., Sun, M. F., Mohammed, B. M., Cheng, Q., Dickeson, S. K., Kundu, S., Verhamme, I. M., Gruber, A., McCrae, K. & Gailani, D., Mar 7 2019, In : Blood. 133, 10, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

Hereditary Angioedemas
Factor XII
Prekallikrein
Kallikreins
Chemical activation

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Mohammed, B. M., Cheng, Q., Matafonov, A., Verhamme, I. M., Emsley, J., McCrae, K. R., McCarty, O., Gruber, A. & Gailani, D., Jan 1 2019, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Factor XI
Glycosaminoglycans
Blood Vessels
Prekallikrein
Heparin
Turkey
Fever
Climate
Emerging Communicable Diseases
Ticks

Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity

Munhenzva, I. R., Barth, C. W., Sibrian-Vazquez, M., Wang, L. G., Escobedo, J. O., Gibbs, S. & Strongin, R. M., Jan 1 2019, In : Methods.

Research output: Contribution to journalArticle

Fluorophores
Pancreatic Neoplasms
Adenocarcinoma
Tissue
Ducts

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion

Ngo, A. T. P., Sheriff, J., Rocheleau, A. D., Bucher, M., Jones, K. R., Sepp, A. L. I., Malone, L. E., Zigomalas, A., Maloyan, A., Bahou, W. F., Bluestein, D., McCarty, O. & Haley, K., Jan 1 2019, In : Platelets.

Research output: Contribution to journalArticle

Blood Platelets
Thrombin
Adenosine Diphosphate
Fetal Blood
PAR-1 Receptor

A statistical virtual patient population for the glucoregulatory system in type 1 diabetes with integrated exercise model

Resalat, N., El Youssef, J., Tyler, N., Castle, J. & Jacobs, P., Jan 1 2019, In : PloS one. 14, 7, e0217301.

Research output: Contribution to journalArticle

Open Access
insulin-dependent diabetes mellitus
Medical problems
Type 1 Diabetes Mellitus
exercise
Hormones

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Coleman, D. J., Gao, L., King, C. J., Schwartzman, J., Urrutia, J., Sehrawat, A., Tayou, J., Balter, A., Burchard, J., Chiotti, K. E., Derrick, D. S., Sun, D., Xia, Z., Heiser, L. & Alumkal, J., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Prostatic Neoplasms
RNA Sequence Analysis
Neoplasms
2 Citations (Scopus)

Biomimetic modification of poly(vinyl alcohol): Encouraging endothelialization and preventing thrombosis with antiplatelet monotherapy

Anderson, D. E. J., Truong, K. P., Hagen, M. W., Yim, E. K. F. & Hinds, M., Jan 1 2019, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Biomimetics
Platelets
Thrombosis
Alcohols
Blood Platelets
1 Citation (Scopus)

Computational Estimation of Microsecond to Second Atomistic Folding Times

Adhikari, U., Mostofian, B., Copperman, J., Subramanian, S. R., Petersen, A. A. & Zuckerman, D., Apr 24 2019, In : Journal of the American Chemical Society. 141, 16, p. 6519-6526 8 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Viscosity
Proteins
Molecular dynamics
Uncertainty
1 Citation (Scopus)

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Lorentz, C. U., Verbout, N. G., Wallisch, M., Hagen, M. W., Shatzel, J. J., Olson, S. R., Puy, C., Hinds, M., McCarty, O., Gailani, D., Gruber, A. & Tucker, E., Apr 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Open Access
Factor XI
Antibodies
Thrombosis
Hemostasis
Primates

Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level

Schaefer, J. M., Barth, C. W., Davis, S. C. & Gibbs, S., Feb 1 2019, In : Journal of biomedical optics. 24, 2, p. 1-9 9 p.

Research output: Contribution to journalArticle

staining
margins
Imaging techniques
Coloring Agents
Contrast Media

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Puy, C., Ngo, A. T. P., Pang, J., Keshari, R. S., Hagen, M. W., Hinds, M., Gailani, D., Gruber, A., Lupu, F. & McCarty, O., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1390-1401 12 p.

Research output: Contribution to journalArticle

Open Access
Factor XIa
Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Endothelial Cells
Kallikreins

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Protein-Tyrosine Kinases
Bone

GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling

Luoh, S-W., Wagoner, W., Wang, X., Hu, Z., Lai, X., Chin, K-Y., Sears, R. & Ramsey, E., Jan 1 2019, In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
Small Interfering RNA
Growth
GRB7 Adaptor Protein

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

Rocheleau, A. D., Melrose, A. R., Cunliffe, J. M., Klimek, J., Babur, O., Tassi Yunga, S., Ngo, A. T. P., Pang, J., David, L., McCarty, O. & Aslan, J., Jan 1 2019, In : Proteomics. 1900001.

Research output: Contribution to journalArticle

Methylation
Platelets
Systems Analysis
Lysine
Identification (control systems)
1 Citation (Scopus)

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death

Silasi, R., Keshari, R. S., Lupu, C., Van Rensburg, W. J., Chaaban, H., Regmi, G., Shamanaev, A., Shatzel, J. J., Puy, C., Lorentz, C. U., Tucker, E., Gailani, D., Gruber, A., McCarty, O. & Lupu, F., Feb 26 2019, In : Blood advances. 3, 4, p. 658-669 12 p.

Research output: Contribution to journalArticle

Open Access
Factor XI
Contact Inhibition
Papio
Sepsis
Disseminated Intravascular Coagulation

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

The Cancer Genome Atlas Network, Jul 30 2019, In : Cell Reports. 28, 5, p. 1370-1384.e5

Research output: Contribution to journalArticle

Open Access
Atlases
p53 Genes
Tumors
Genes
Genome

Lanthanide-Loaded Nanoparticles as Potential Fluorescent and Mass Probes for High-Content Protein Analysis

Ngamcherdtrakul, W., Sangvanich, T., Goodyear, S., Reda, M., Gu, S., Castro, D. J., Punnakitikashem, P. & Yantasee, W., Mar 1 2019, In : Bioengineering. 6, 1, 23.

Research output: Contribution to journalArticle

Open Access
Lanthanoid Series Elements
Rare earth elements
Antibodies
Nanoparticles
Proteins

Luminal plasma treatment for small diameter polyvinyl alcohol tubular scaffolds

Pohan, G., Chevallier, P., Anderson, D. E. J., Tse, J. W., Yao, Y., Hagen, M. W., Mantovani, D., Hinds, M. & Yim, E. K. F., Jan 1 2019, In : Frontiers in Bioengineering and Biotechnology. 7, MAY, 117.

Research output: Contribution to journalArticle

Polyvinyl Alcohol
Polyvinyl alcohols
Scaffolds
Grafts
Blood Vessels
1 Citation (Scopus)

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Coleman, D. J., Gao, L., Schwartzman, J., Korkola, J., Sampson, D., Derrick, D. S., Urrutia, J., Balter, A., Burchard, J., King, C. J., Chiotti, K. E., Heiser, L. & Alumkal, J., Dec 1 2019, In : Scientific Reports. 9, 1, 3823.

Research output: Contribution to journalArticle

Open Access
Castration
Prostatic Neoplasms
Maintenance
Androgen Receptors
Cell Line

Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α

Spiriti, J., Subramanian, S. R., Palli, R., Wu, M. & Zuckerman, D., Apr 1 2019, In : PloS one. 14, 4, e0215694.

Research output: Contribution to journalArticle

Open Access
Estrogen Receptors
prediction
Proteins
proteins
Ligands

Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation

Lakshmanan, H. H. S., Shatzel, J. J., Olson, S. R., McCarty, O. & Maddala, J., Jan 1 2019, In : Computer Methods in Biomechanics and Biomedical Engineering.

Research output: Contribution to journalArticle

Bifurcation (mathematics)
Blood vessels
Microfluidics
Shear deformation
Blood
3 Citations (Scopus)

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., Riggers, R., Samatham, R., Amery, T. S., Jacques, S., Sheppard, B., Korkola, J., Muschler, J., Thibault, G., Chang, Y. H., Gray, J., Presnell, S. C., Nguyen, D. G. & Sears, R., Jan 15 2019, In : Cell Reports. 26, 3, p. 608-623.e6

Research output: Contribution to journalArticle

Bioprinting
Tumors
Tissue
Phenotype
Scaffolds
1 Citation (Scopus)

Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients

Chu, Y., Elrod, N., Wang, C., Li, L., Chen, T., Routh, A., Xia, Z., Li, W., Wagner, E. J. & Ji, P., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Polyadenylation
Glioblastoma
3' Untranslated Regions
Glioma
Genes

Optical properties of living corals determined with diffuse reflectance spectroscopy

Jacques, S., Wangpraseurt, D. & Kühl, M., Jan 1 2019, In : Frontiers in Marine Science. 6, JUL, 472.

Research output: Contribution to journalArticle

Open Access
optical properties
optical property
corals
coral
reflectance

Prediction of Hypoglycemia During Aerobic Exercise in Adults With Type 1 Diabetes

Reddy, R., Resalat, N., Wilson, L. M., Castle, J., El Youssef, J. & Jacobs, P., Jan 1 2019, In : Journal of diabetes science and technology.

Research output: Contribution to journalArticle

Medical problems
Type 1 Diabetes Mellitus
Hypoglycemia
Exercise
Heart Rate
Neoplasm Genes
Missense Mutation
Hinges
Dynamic analysis
Genes

Removal of a gadolinium based contrast agent by a novel sorbent hemoperfusion in a chronic kidney disease (CKD) rodent model

Ngamcherdtrakul, W., Morry, J., Sangvanich, T., Reda, M., Bejan, D. S., Fryxell, G. E. & Yantasee, W., Dec 1 2019, In : Scientific Reports. 9, 1, 709.

Research output: Contribution to journalArticle

Hemoperfusion
Gadolinium
Chronic Renal Insufficiency
Contrast Media
Rodentia

Robust Cell Detection and Segmentation for Image Cytometry Reveal Th17 Cell Heterogeneity

Tsujikawa, T., Thibault, G., Azimi, V., Sivagnanam, S., Banik, G., Means, C., Kawashima, R., Clayburgh, D., Gray, J., Coussens, L. & Chang, Y. H., Jan 1 2019, In : Cytometry Part A.

Research output: Contribution to journalArticle

Image Cytometry
Th17 Cells
Papillomaviridae
Immunohistochemistry
Biomarkers
2 Citations (Scopus)

Selective capture of radionuclides (U, Pu, Th, Am and Co) using functional nanoporous sorbents

Yantasee, W., Fryxell, G. E., Pattamakomsan, K., Sangvanich, T., Wiacek, R. J., Busche, B., Addleman, R. S., Timchalk, C., Ngamcherdtrakul, W. & Siriwon, N., Mar 15 2019, In : Journal of Hazardous Materials. 366, p. 677-683 7 p.

Research output: Contribution to journalArticle

Organophosphonates
Seawater
Sorbents
Actinoid Series Elements
Radioisotopes

Sensory re-weighting for postural control in Parkinson’s disease

Feller, K. J., Peterka, R. B. & Horak, F., Feb 1 2019, In : Frontiers in Human Neuroscience. 13, 126.

Research output: Contribution to journalArticle

Open Access
Parkinson Disease
Aptitude
Weights and Measures
Proprioception
Behavior Control

Static spatial growth restriction micropatterning of endothelial colony forming cells influences their morphology and gene expression

Hagen, M. W. & Hinds, M., Jun 1 2019, In : PloS one. 14, 6, e0218197.

Research output: Contribution to journalArticle

Open Access
Gene expression
Endothelial cells
Gene Expression
Elongation
gene expression
1 Citation (Scopus)
Uncertainty analysis
statistical analysis
intervals
confidence
Rate constants

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M., May 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Gene therapy
Dependovirus
Viruses
Genetic Therapy
Electron Microscope Tomography

Targeting mitochondria in cancer therapy could provide a basis for the selective anticancer activity

Rozanov, D., Cheltsov, A., Nilsen, A., Boniface, C., Forquer, I., Korkola, J., Gray, J., Tyner, J., Tognon, C. E., Mills, G. & Spellman, P., Mar 1 2019, In : PloS one. 14, 3, e0205623.

Research output: Contribution to journalArticle

Open Access
Mitochondria
Assays
mitochondria
therapeutics
neoplasms

The role of coagulation and platelets in colon cancer-associated thrombosis

Mitrugno, A., Tassi Yunga, S., Sylman, J. L., Zilberman-Rudenko, J., Shirai, T., Hebert, J. F., Kayton, R., Zhang, Y., Nan, X., Shatzel, J. J., Esener, S., Duvernay, M. T., Hamm, H. E., Gruber, A., Williams, C. D., Takata, Y., Armstrong, R., Morgan, T. & McCarty, O., Feb 1 2019, In : American journal of physiology. Cell physiology. 316, 2, p. C264-C273

Research output: Contribution to journalArticle

Colonic Neoplasms
Thrombosis
Blood Platelets
Neoplasms
Cell Communication

The Safety and Efficacy of Novel Agents Targeting Factors XI and XII in Early Phase Human Trials

Deloughery, E. P., Olson, S. R., Puy, C., McCarty, O. & Shatzel, J. J., Jan 1 2019, In : Seminars in Thrombosis and Hemostasis. 45, 5, p. 502-508 7 p.

Research output: Contribution to journalArticle

Factor XI
Factor XII
Safety
Monoclonal Antibodies
Oral Hemorrhage
2 Citations (Scopus)

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

Latifi, Y., Moccetti, F., Wu, M., Xie, A., Packwood, W., Yue, Q., Ozawa, K., Shentu, W., Brown, E., Shirai, T., McCarty, O., Ruggeri, Z., Moslehi, J., Chen, J., Druker, B., López, J. A. & Lindner, J., Apr 4 2019, In : Blood. 133, 14, p. 1597-1606 10 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
von Willebrand Factor
Protein-Tyrosine Kinases
Platelets
Toxicity

Using Artificial Intelligence to Improve the Quality and Safety of Radiation Therapy

Pillai, M., Adapa, K., Das, S. K., Mazur, L., Dooley, J., Marks, L. B., Thompson, R. & Chera, B. S., Jan 1 2019, In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Radiation Oncology
Artificial Intelligence
Radiotherapy
Safety
Clinical Decision Support Systems

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Smith, R., Devlin, K., Kilburn, D., Gross, S., Sudar, D., Bucher, E., Nederlof, M., Dane, M., Gray, J. W., Heiser, L. & Korkola, J., May 21 2019, In : Journal of visualized experiments : JoVE. 147

Research output: Contribution to journalArticle

Microarrays
Assays
Proteins
Complex Mixtures
Phenotype
2018
1 Citation (Scopus)

Accuracy of wrist-worn activity monitors during common daily physical activities and types of structured exercise: Evaluation study

Kondama Reddy, R., Pooni, R., Zaharieva, D. P., Senf, B., El Youssef, J., Dassau, E., Doyle, F. J., Clements, M. A., Rickels, M. R., Patton, S. R., Castle, J., Riddell, M. C. & Jacobs, P., Dec 1 2018, In : JMIR mHealth and uHealth. 6, 12, e10338.

Research output: Contribution to journalArticle

Wrist
Heart Rate
Exercise
Energy Metabolism
Indirect Calorimetry

Animal models for heart valve research and development

Kheradvar, A., Zareian, R., Kawauchi, S., Goodwin, R. L. & Rugonyi, S., Jan 1 2018, (Accepted/In press) In : Drug Discovery Today: Disease Models.

Research output: Contribution to journalArticle

Heart Valve Diseases
Heart Valves
Animal Models
Research
Epigenomics
10 Citations (Scopus)

Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation?

Thompson, R., Valdes, G., Fuller, C. D., Carpenter, C. M., Morin, O., Aneja, S., Lindsay, W. D., Aerts, H. J. W. L., Agrimson, B., Deville, C., Rosenthal, S. A., Yu, J. B. & Thomas, C., Jan 1 2018, (Accepted/In press) In : Radiotherapy and Oncology.

Research output: Contribution to journalArticle

Radiation Oncology
Artificial Intelligence
Radiology
Industry
Medicine
1 Citation (Scopus)

A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patients

Sylman, J. L., Boyce, H. B., Mitrugno, A., Tormoen, G. W., Thomas, I. C., Wagner, T. H., Lee, J. S., Leppert, J. T., McCarty, O. & Mallick, P., Dec 1 2018, In : Scientific Reports. 8, 1, 6564.

Research output: Contribution to journalArticle

Platelet Count
Colonic Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Thrombocytosis
2 Citations (Scopus)

Biology needs evolutionary software tools: Let's build them right

Nekrutenko, A., Team, G., Goecks, J., Taylor, J. & Blankenberg, D., Jun 1 2018, In : Molecular Biology and Evolution. 35, 6, p. 1372-1375 4 p.

Research output: Contribution to journalArticle

life science
Software
Biological Science Disciplines
software
Biological Sciences

Bleeding TAPs out

Ngo, A. T. P., Aslan, J. & McCarty, O., Jan 1 2018, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Hemorrhage
13 Citations (Scopus)

CCR5 Governs DNA damage repair and breast cancer stem cell expansion

Jiao, X., Velasco-Velazquez, M. A., Wang, M., Li, Z., Rui, H., Peck, A. R., Korkola, J., Chen, X., Xu, S., DuHadaway, J. B., Guerrero-Rodriguez, S., Addya, S., Sicoli, D., Mu, Z., Zhang, G., Stucky, A., Zhang, X., Cristofanilli, M., Fatatis, A., Gray, J. & 3 others, Zhong, J. F., Prendergast, G. C. & Pestell, R. G., Apr 1 2018, In : Cancer Research. 78, 7, p. 1657-1671 15 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
DNA Repair
DNA Damage
Breast Neoplasms
Epithelial Cells
15 Citations (Scopus)

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S., Fischer, J. & 8 others, Jaboin, J., Billingsley, K., Lopez, C., Burchard, J., Gray, J., Coussens, L., Sheppard, B. & Wong, M., Sep 12 2018, In : Science advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

Cell Fusion
Hybrid Cells
Survival
Neoplasms
Biomarkers