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2019

Altered Protein Dynamics and Increased Aggregation of Human γs-Crystallin Due to Cataract-Associated Deamidations

Forsythe, H. M., Vetter, C. J., Jara, K. A., Reardon, P. N., David, L. L., Barbar, E. J. & Lampi, K. J., Oct 8 2019, In : Biochemistry. 58, 40, p. 4112-4124 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Savage, J. C., Shinde, P., Bächinger, H. P., Davare, M. A. & Shinde, U., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5882-5885 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children

Balamurugan, K., Kavitha, B., Yang, Z., Mohan, V., Radha, V. & Shyng, S-L., Jan 1 2019, In : Pediatric Diabetes.

Research output: Contribution to journalArticle

3 Scopus citations

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

Rocheleau, A. D., Melrose, A. R., Cunliffe, J. M., Klimek, J., Babur, O., Tassi Yunga, S., Ngo, A. T. P., Pang, J., David, L., McCarty, O. & Aslan, J., Jan 1 2019, In : Proteomics. 1900001.

Research output: Contribution to journalArticle

Identification of PKCα-dependent phosphoproteins in mouse retina

Wakeham, C. M., Wilmarth, P., Cunliffe, J. M., Klimek, J. E., Ren, G., David, L. & Morgans, C., Aug 30 2019, In : Journal of Proteomics. 206, 103423.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

Martin, G. M., Sung, M. W., Yang, Z., Innes, L. M., Kandasamy, B., David, L., Yoshioka, C. & Shyng, S-L., Jul 1 2019, In : eLife. 8, e46417.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Novel dominant KATP channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping

Boodhansingh, K. E., Kandasamy, B., Mitteer, L., Givler, S., De Leon, D. D., Shyng, S-L., Ganguly, A. & Stanley, C. A., Jan 1 2019, (Accepted/In press) In : American Journal of Medical Genetics, Part A.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. & Cvekl, A., Feb 1 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

Krishna Kumar, K., Shalev-Benami, M., Robertson, M. J., Hu, H., Banister, S. D., Hollingsworth, S. A., Latorraca, N. R., Kato, H. E., Hilger, D., Maeda, S., Weis, W. I., Farrens, D., Dror, R. O., Malhotra, S. V., Kobilka, B. K. & Skiniotis, G., Jan 24 2019, In : Cell. 176, 3, p. 448-458.e12

Research output: Contribution to journalArticle

45 Scopus citations

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M., May 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

Arttamangkul, S., Plazek, A., Platt, E. J., Jin, H., Murray, T. F., Birdsong, W. T., Rice, K. C., Farrens, D. L. & Williams, J. T., Oct 7 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2018
1 Scopus citations

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J., Staverosky, J., Reddy, A. P., Wilmarth, P., David, L., Acott, T., Russell, P. & Raghunathan, V. K., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Hulett, T. W., Jensen, S. M., Wilmarth, P., Reddy, A. P., Ballesteros-Merino, C., Afentoulis, M. E., Dubay, C., David, L. & Fox, B. A., Apr 5 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 27.

Research output: Contribution to journalArticle

4 Scopus citations

Data Descriptor: Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Krey, J. F., Scheffer, D. I., Choi, D., Reddy, A., David, L. L., Corey, D. P. & Barr-Gillespie, P. G., Jul 17 2018, In : Scientific Data. 5, 180128.

Research output: Contribution to journalArticle

1 Scopus citations

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells

VanSlyke, J. K., Boswell, B. A. & Musil, L., Nov 1 2018, In : Journal of Cell Science. 131, 22, jcs217240.

Research output: Contribution to journalArticle

1 Scopus citations

GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate

Plubell, D. L., Fenton, A. M., Wilmarth, P. A., Bergstrom, P., Zhao, Y., Minnier, J., Heinecke, J. W., Yang, X. & Pamir, N., Dec 1 2018, In : Scientific Reports. 8, 1, 11485.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens

Martynova, E., Bouchard, M., Musil, L. & Cvekl, A., Nov 1 2018, In : Developmental Dynamics. 247, 11, p. 1186-1198 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M. A., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M., Druker, B. J., Singer, J. W. & Agarwal, A., Nov 1 2018, In : Leukemia. 32, 11, p. 2374-2387 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing

Platt, E. J., Smith, L. & Thayer, M. J., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 541-553 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W., VanSlyke, J. K., Musil, L., Fletcher, J. A., Tyner, J. & Heinrich, M., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

2 Scopus citations

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection

Rozanov, D., Rozanov, N. D., Chiotti, K. E., Reddy, A., Wilmarth, P., David, L., Cha, S. W., Woo, S., Pevzner, P., Bafna, V., Burrows, G. G., Rantala, J. K., Levin, T., Anur, P., Johnson-Camacho, K., Tabatabaei, S., Munson, D. J., Bruno, T. C., Slansky, J. E., Kappler, J. W. & 9 others, Hirano, N., Boegel, S., Fox, B. A., Egelston, C., Simons, D. L., Jimenez, G., Lee, P. P., Gray, J. & Spellman, P., Mar 30 2018, In : Journal of Proteomics. 176, p. 13-23 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Babur, O., Ngo, A. T. P., Rigg, R. A., Pang, J., Rub, Z. T., Buchanan, A. E., Mitrugno, A., David, L., McCarty, O., Demir, E. & Aslan, J., May 1 2018, In : American journal of physiology. Cell physiology. 314, 5, p. C603-C615

Research output: Contribution to journalArticle

3 Scopus citations

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

Walsh, S. M., Mathiasen, S., Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, S. G. F., Fung, J. J., Filizola, M., Hristova, K., Kobilka, B., Farrens, D. L. & Stamou, D., Jul 17 2018, In : Biophysical Journal. 115, 2, p. 300-312 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

Research output: Contribution to journalArticle

28 Scopus citations

Adenoassociated virus (AAV) serotypes have distinctive interactions with domains of the cellular AAV receptor

Pillay, S., Zou, W., Cheng, F., Puschnik, A. S., Meyer, N. L., Ganaie, S. S., Deng, X., Wosen, J. E., Davulcu, O., Yan, Z., Engelhardt, J. F., Brown, K. E., Chapman, M., Qiu, J. & Carette, J. E., Sep 1 2017, In : Journal of Virology. 91, 18, e00391-17.

Research output: Contribution to journalArticle

34 Scopus citations

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S-L., Oct 16 2017, In : eLife. 6, e31054.

Research output: Contribution to journalArticle

38 Scopus citations

Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes

Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P. A., Li, Y., Riscoe, M. K., Ullman, B. & Roberts, S. C., Jan 1 2017, In : Infection and Immunity. 85, 1, e00554-16.

Research output: Contribution to journalArticle

21 Scopus citations

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

69 Scopus citations

Dual function of TGFβ in lens epithelial cell fate: Implications for secondary cataract

Boswell, B. A., Korol, A., West-Mays, J. A. & Musil, L. S., Apr 1 2017, In : Molecular biology of the cell. 28, 7, p. 907-921 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

Elevated μs-ms timescale backbone dynamics in the transition state analog form of arginine kinase

Davulcu, O., Peng, Y., Brüschweiler, R., Skalicky, J. J. & Chapman, M., Apr 11 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

1 Scopus citations

Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue

Plubell, D. L., Wilmarth, P., Zhao, Y., Fenton, A. M., Minnier, J., Reddy, A. P., Klimek, J., Yang, X., David, L. & Pamir, N., May 1 2017, In : Molecular and Cellular Proteomics. 16, 5, p. 873-890 18 p.

Research output: Contribution to journalArticle

37 Scopus citations
16 Scopus citations
5 Scopus citations

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. C. & Shyng, S-L., 2017, In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Persulfide Formation Mediates Cysteine and Homocysteine Biosynthesis in Methanosarcina acetivorans

Rauch, B. J., Klimek, J., David, L. & Perona, J. J., Feb 28 2017, In : Biochemistry. 56, 8, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Proteomic analysis of the bovine and human ciliary zonule

De Maria, A., Wilmarth, P. A., David, L. L. & Bassnett, S., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 573-585 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
7 Scopus citations

Targeting the gut microbiota-FXR signaling axis for glycemic control: Does a dietary supplement work Magic?

Shyng, S-L., Mar 1 2017, In : Diabetes. 66, 3, p. 571-573 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Xie, Q., Spear, J. M., Noble, A. J., Sousa, D. R., Meyer, N. L., Davulcu, O., Zhang, F., Linhardt, R. J., Stagg, S. M. & Chapman, M., Jun 16 2017, In : Molecular Therapy - Methods and Clinical Development. 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

The Michaelis Complex of Arginine Kinase Samples the Transition State at a Frequency That Matches the Catalytic Rate

Peng, Y., Hansen, A. L., Bruschweiler-Li, L., Davulcu, O., Skalicky, J. J., Chapman, M. & Brüschweiler, R., Apr 5 2017, In : Journal of the American Chemical Society. 139, 13, p. 4846-4853 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function

Posner, M., Murray, K. L., McDonald, M. S., Eighinger, H., Andrew, B., Drossman, A., Haley, Z., Nussbaum, J., David, L. & Lampi, K., Jan 1 2017, In : PeerJ. 2017, 11, 4093.

Research output: Contribution to journalArticle

3 Scopus citations
2016

An essential receptor for adeno-associated virus infection

Pillay, S., Meyer, N. L., Puschnik, A. S., Davulcu, O., Diep, J., Ishikawa, Y., Jae, L. T., Wosen, J. E., Nagamine, C. M., Chapman, M. & Carette, J. E., Feb 4 2016, In : Nature. 530, 7588, p. 108-112 5 p.

Research output: Contribution to journalArticle

135 Scopus citations

A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani

Martin, J. L., Yates, P., Boitz, J. M., Koop, D., Fulwiler, A. L., Cassera, M. B., Ullman, B. & Carter, N., Jul 1 2016, In : Molecular Microbiology. 101, 2, p. 299-313 15 p.

Research output: Contribution to journalArticle

9 Scopus citations