Research Output 1970 2019

2019

A ribose modification of Spinach aptamer accelerates lead(ii) cation association: In vitro

Savage, J. C., Shinde, P., Bächinger, H. P., Davare, M. & Shinde, U., Jan 1 2019, In : Chemical Communications. 55, 42, p. 5882-5885 4 p.

Research output: Contribution to journalArticle

Ribose
Cations
Lead
Positive ions
Fluorescence

Curriculum Reform: A View From the Other Side

Ullman, B., Apr 1 2019, In : Academic medicine : journal of the Association of American Medical Colleges. 94, 4, 1 p.

Research output: Contribution to journalArticle

curriculum
reform

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Acute Myeloid Leukemia
DNA
DNA Damage
1 Citation (Scopus)

Functional characterization of activating mutations in the sulfonylurea receptor 1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children

Balamurugan, K., Kavitha, B., Yang, Z., Mohan, V., Radha, V. & Shyng, S-L., Jan 1 2019, In : Pediatric Diabetes.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Diabetes Mellitus
Adenosine Triphosphate
Mutation
Adenosine Diphosphate

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets

Rocheleau, A. D., Melrose, A. R., Cunliffe, J. M., Klimek, J., Babur, O., Tassi Yunga, S., Ngo, A. T. P., Pang, J., David, L., McCarty, O. & Aslan, J., Jan 1 2019, In : Proteomics. 1900001.

Research output: Contribution to journalArticle

Methylation
Platelets
Systems Analysis
Lysine
Identification (control systems)

Identification of PKCα-dependent phosphoproteins in mouse retina

Wakeham, C. M., Wilmarth, P., Cunliffe, J. M., Klimek, J. E., Ren, G., David, L. & Morgans, C., Aug 30 2019, In : Journal of Proteomics. 206, 103423.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
Phosphoproteins
Retina
Phosphorylation
Cell Physiological Phenomena
Open Access
KATP Channels
insulin
secretions
Insulin
Leptin
4 Citations (Scopus)

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. & Cvekl, A., Feb 1 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Proteome
Lenses
Epithelium
Proteins
13 Citations (Scopus)

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

Krishna Kumar, K., Shalev-Benami, M., Robertson, M. J., Hu, H., Banister, S. D., Hollingsworth, S. A., Latorraca, N. R., Kato, H. E., Hilger, D., Maeda, S., Weis, W. I., Farrens, D., Dror, R. O., Malhotra, S. V., Kobilka, B. K. & Skiniotis, G., Jan 24 2019, In : Cell. 176, 3, p. 448-458.e12

Research output: Contribution to journalArticle

Cannabinoid Receptors
GTP-Binding Proteins
Chemical activation
Heterotrimeric GTP-Binding Proteins
Cannabinoids

Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

Meyer, N. L., Hu, G., Davulcu, O., Xie, Q., Noble, A. J., Yoshioka, C., Gingerich, D. S., Trzynka, A., David, L., Stagg, S. M. & Chapman, M., May 22 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Gene therapy
Dependovirus
Viruses
Genetic Therapy
Electron Microscope Tomography
2018
1 Citation (Scopus)
Angiogenic Proteins
Retinal Vessels
Proteomics
Endothelial Cells
Pharmaceutical Preparations
4 Citations (Scopus)

Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins

Li, B. X., Chen, J., Chao, B., David, L. & Xiao, X., May 18 2018, In : ACS Chemical Biology. 13, 5, p. 1380-1387 8 p.

Research output: Contribution to journalArticle

Lamins
Intermediate Filament Proteins
Lamin Type A
Cytoskeletal Proteins
Actin Cytoskeleton
2 Citations (Scopus)

Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

Vranka, J., Staverosky, J., Reddy, A. P., Wilmarth, P., David, L., Acott, T., Russell, P. & Raghunathan, V. K., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Proteomics
Pressure
Elastic Modulus
Extracellular Matrix Proteins
2 Citations (Scopus)

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Labeling
Adenosine Diphosphate
NAD
Proteins
4 Citations (Scopus)

Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

Hulett, T. W., Jensen, S. M., Wilmarth, P., Reddy, A. P., Ballesteros-Merino, C., Afentoulis, M. E., Dubay, C., David, L. & Fox, B. A., Apr 5 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 27.

Research output: Contribution to journalArticle

Neoplasm Antigens
Vaccination
Immunoglobulin G
T-Lymphocytes
Antibodies

Data Descriptor: Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells

Krey, J. F., Scheffer, D. I., Choi, D., Reddy, A., David, L., Corey, D. P. & Barr-Gillespie, P., Jul 17 2018, In : Scientific data. 5, 180128.

Research output: Contribution to journalArticle

Mass Spectrometry
Descriptors
Digital differential analyzers
Mass spectrometry
Cells
3 Citations (Scopus)

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells

Krey, J. F., Dumont, R. A., Wilmarth, P., David, L., Johnson, K. R. & Barr-Gillespie, P., Jan 24 2018, In : Journal of Neuroscience. 38, 4, p. 843-857 15 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Guanosine Triphosphate
Hydrolysis
ADP-Ribosylation Factors
Saccule and Utricle

Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells

VanSlyke, J. K., Boswell, B. A. & Musil, L., Nov 1 2018, In : Journal of Cell Science. 131, 22, jcs217240.

Research output: Contribution to journalArticle

Fibronectins
Lenses
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Cataract

GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate

Plubell, D. L., Fenton, A. M., Wilmarth, P., Bergstrom, P., Zhao, Y., Minnier, J., Heinecke, J. W., Yang, X. & Pamir, N., Dec 1 2018, In : Scientific Reports. 8, 1, 11485.

Research output: Contribution to journalArticle

Myeloid Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Weight Gain
Insulin Resistance
Adipose Tissue
1 Citation (Scopus)

Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens

Martynova, E., Bouchard, M., Musil, L. & Cvekl, A., Nov 1 2018, In : Developmental Dynamics. 247, 11, p. 1186-1198 13 p.

Research output: Contribution to journalArticle

Lenses
Transcription Factors
Binding Sites
Urogenital System
Chromatin Assembly and Disassembly
1 Citation (Scopus)

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M. T., Druker, B., Singer, J. W. & Agarwal, A., Mar 29 2018, (Accepted/In press) In : Leukemia. p. 1-14 14 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor-Associated Kinases
Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Heterografts
5 Citations (Scopus)

L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing

Platt, E. J., Smith, L. & Thayer, M. M., Feb 1 2018, In : Journal of Cell Biology. 217, 2, p. 541-553 13 p.

Research output: Contribution to journalArticle

DNA Replication Timing
Long Noncoding RNA
Antisense RNA
Retroelements
Chromosomes
Lacrimal Apparatus
Nociception
Denervation
Tears
Menthol

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Klug, L. R., Bannon, A. E., Javidi-Sharifi, N., Town, A., Fleming, W., VanSlyke, J. K., Musil, L., Fletcher, J. A., Tyner, J. & Heinrich, M., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Lemur
Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Melanoma
Small Interfering RNA
2 Citations (Scopus)

Methods for characterizing disease-associated ATP-sensitive potassium channel mutations

Kandasamy, B. & Shyng, S-L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 85-104 20 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceedingChapter

KATP Channels
Sulfonylurea Receptors
Mutation
Congenital Hyperinsulinism
Insulin
5 Citations (Scopus)

MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection

Rozanov, D., Rozanov, N. D., Chiotti, K. E., Reddy, A., Wilmarth, P., David, L., Cha, S. W., Woo, S., Pevzner, P., Bafna, V., Burrows, G. G., Rantala, J. K., Levin, T., Anur, P., Johnson-Camacho, K., Tabatabaei, S., Munson, D. J., Bruno, T. C., Slansky, J. E., Kappler, J. W. & 9 others, Hirano, N., Boegel, S., Fox, B. A., Egelston, C., Simons, D. L., Jimenez, G., Lee, P. P., Gray, J. & Spellman, P., Mar 30 2018, In : Journal of Proteomics. 176, p. 13-23 11 p.

Research output: Contribution to journalArticle

Cells
Breast Neoplasms
Ligands
Cell Line
Peptides
3 Citations (Scopus)

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Babur, O., Ngo, A. T. P., Rigg, R. A., Pang, J., Rub, Z. T., Buchanan, A. E., Mitrugno, A., David, L., McCarty, O., Demir, E. & Aslan, J., May 1 2018, In : American journal of physiology. Cell physiology. 314, 5, p. C603-C615

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Blood Platelets
Phenotype
Hemostatics
Systems Biology

Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-l-phenylalanine

Devaraneni, P., Rex, E. A. & Shyng, S-L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 51-61 11 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceedingChapter

KATP Channels
Phenylalanine
Ligands
Potassium Channels
Sulfonylurea Receptors
4 Citations (Scopus)

Single Proteoliposome High Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

Walsh, S. M., Mathiasen, S., Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, S. G. F., Fung, J. J., Filizola, M., Hristova, K., Kobilka, B., Farrens, D. & Stamou, D., Jan 1 2018, (Accepted/In press) In : Biophysical Journal.

Research output: Contribution to journalArticle

Hominidae
G-Protein-Coupled Receptors
CCR10 Receptors
Opsins
Cannabinoid Receptors
2017
22 Citations (Scopus)

Adeno-associated virus (AAV) assembly-activating protein is not an essential requirement for capsid assembly of AAV serotypes 4, 5, and 11

Earley, L. F., Powers, J. M., Adachi, K., Baumgart, J. T., Meyer, N. L., Xie, Q., Chapman, M. & Nakai, H., 2017, In : Journal of Virology. 91, 3, e01980-16.

Research output: Contribution to journalArticle

Dependovirus
Virus Assembly
capsid
Capsid
serotypes
19 Citations (Scopus)

Adenoassociated virus (AAV) serotypes have distinctive interactions with domains of the cellular AAV receptor

Pillay, S., Zou, W., Cheng, F., Puschnik, A. S., Meyer, N. L., Ganaie, S. S., Deng, X., Wosen, J. E., Davulcu, O., Yan, Z., Engelhardt, J. F., Brown, K. E., Chapman, M., Qiu, J. & Carette, J. E., Sep 1 2017, In : Journal of Virology. 91, 18, e00391-17.

Research output: Contribution to journalArticle

Dependovirus
Virus Receptors
serotypes
Viruses
viruses
2 Citations (Scopus)

Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry

Krey, J. F., Wilmarth, P., David, L. & Barr-Gillespie, P., 2017, Methods in Enzymology. Academic Press Inc., Vol. 585. p. 329-354 26 p. (Methods in Enzymology; vol. 585).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stereocilia
Proteome
Hair
Mass spectrometry
Mass Spectrometry
25 Citations (Scopus)

Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

Martin, G. M., Kandasamy, B., Dimaio, F., Yoshioka, C. & Shyng, S-L., Oct 16 2017, In : eLife. 6, e31054.

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Binding Sites
Pharmaceutical Preparations
Adenosine Triphosphate
18 Citations (Scopus)

Arginase is essential for survival of Leishmania donovani promastigotes but not intracellular amastigotes

Boitz, J. M., Gilroy, C. A., Olenyik, T. D., Paradis, D., Perdeh, J., Dearman, K., Davis, M. J., Yates, P., Li, Y., Riscoe, M., Ullman, B. & Roberts, S. C., 2017, In : Infection and Immunity. 85, 1, e00554-16.

Research output: Contribution to journalArticle

Leishmania donovani
Arginase
Polyamines
Ornithine
Parasites
2 Citations (Scopus)

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Yeasts
Neoplasms
Early Detection of Cancer
Genes
8 Citations (Scopus)

Caught in the act -protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

Thomas, G., Aslan, J., Thomas, L., Shinde, P., Shinde, U. & Simmen, T., Jun 1 2017, In : Journal of Cell Science. 130, 11, p. 1865-1876 12 p.

Research output: Contribution to journalComment/debate

Homeostasis
Vertebrates
Proteins
Cell Physiological Phenomena
Communication
56 Citations (Scopus)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations
13 Citations (Scopus)

Dual function of TGFβ in lens epithelial cell fate: Implications for secondary cataract

Boswell, B. A., Korol, A., West-Mays, J. A. & Musil, L., Apr 1 2017, In : Molecular Biology of the Cell. 28, 7, p. 907-921 15 p.

Research output: Contribution to journalArticle

Capsule Opacification
Lenses
Epithelial Cells
Cell Differentiation
MAP Kinase Signaling System
1 Citation (Scopus)

Elevated μs-ms timescale backbone dynamics in the transition state analog form of arginine kinase

Davulcu, O., Peng, Y., Brüschweiler, R., Skalicky, J. J. & Chapman, M., Apr 11 2017, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

Arginine Kinase
Enzymes
Magnetic Resonance Spectroscopy
Catalysis
Arginine
17 Citations (Scopus)

Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue

Plubell, D. L., Wilmarth, P., Zhao, Y., Fenton, A. M., Minnier, J., Reddy, A. P., Klimek, J., Yang, X., David, L. & Pamir, N., May 1 2017, In : Molecular and Cellular Proteomics. 16, 5, p. 873-890 18 p.

Research output: Contribution to journalArticle

High Fat Diet
Proteome
Nutrition
Multiplexing
Labeling
11 Citations (Scopus)
Hemodynamics
Endocardium
Confocal Microscopy
Electron Scanning Microscopy
Proteomics
4 Citations (Scopus)
Myofibrils
Myocardium
Hemodynamics
Proteomics
Renin-Angiotensin System
3 Citations (Scopus)

NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic Β-cells

Wu, Y., Fortin, D. A., Cochrane, V. A., Chen, P. C. & Shyng, S-L., 2017, In : Journal of Biological Chemistry. 292, 37, p. 15512-15524 13 p.

Research output: Contribution to journalArticle

Potassium Channels
Leptin
N-Methyl-D-Aspartate Receptors
KATP Channels
AMP-Activated Protein Kinases
6 Citations (Scopus)

Parasite polyamines as pharmaceutical targets

Roberts, S. & Ullman, B., Jan 1 2017, In : Current Pharmaceutical Design. 23, 23, p. 3325-3341 17 p.

Research output: Contribution to journalReview article

Polyamines
Parasites
Pharmaceutical Preparations
African Trypanosomiasis
Eflornithine
3 Citations (Scopus)

Persulfide Formation Mediates Cysteine and Homocysteine Biosynthesis in Methanosarcina acetivorans

Rauch, B. J., Klimek, J., David, L. & Perona, J. J., Feb 28 2017, In : Biochemistry. 56, 8, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

Methanosarcina
Biosynthesis
Homocysteine
RNA, Transfer, Cys
Cysteine
14 Citations (Scopus)

Proteomic analysis of the bovine and human ciliary zonule

De Maria, A., Wilmarth, P., David, L. & Bassnett, S., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 573-585 13 p.

Research output: Contribution to journalArticle

Proteomics
Proteins
Mass Spectrometry
Ectopia Lentis
High Pressure Liquid Chromatography
3 Citations (Scopus)
Epithelial-Mesenchymal Transition
Heat-Shock Proteins
Proteomics
Lenses
Glutathione
3 Citations (Scopus)

Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods

Fay, J. F. & Farrens, D., 2017, Methods in Enzymology. Academic Press Inc., Vol. 593. p. 343-370 28 p. (Methods in Enzymology; vol. 593).

Research output: Chapter in Book/Report/Conference proceedingChapter

Labeling
Purification
Fluorescence
Cannabinoids
Ligands
1 Citation (Scopus)

Targeting the gut microbiota-FXR signaling axis for glycemic control: Does a dietary supplement work Magic?

Shyng, S-L., Mar 1 2017, In : Diabetes. 66, 3, p. 571-573 3 p.

Research output: Contribution to journalArticle

Magic
Dietary Supplements
Gastrointestinal Microbiome
7 Citations (Scopus)

The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Xie, Q., Spear, J. M., Noble, A. J., Sousa, D. R., Meyer, N. L., Davulcu, O., Zhang, F., Linhardt, R. J., Stagg, S. M. & Chapman, M., Jun 16 2017, In : Molecular Therapy - Methods and Clinical Development. 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

Heparinoids
Dependovirus
Electron Microscopy
Polysaccharides
Heparin